Published in:
Open Access
01-12-2015 | Meeting abstract
Evaluation of NLRP3 inflamassome expression and its endogen inhibitor CGI-58 in subjects with different obesity degrees
Authors:
Jakeline Rheinheimer, Milene Moehlecke, Natali Silva Cardoso, Mariana Lopes dos Santos, Luís Henrique Canani, Cristiane Bauermanno Leitã, Daisy Crispim
Published in:
Diabetology & Metabolic Syndrome
|
Special Issue 1/2015
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Excerpt
Obesity is associated with a state of low-grade chronic inflammation, commonly causing insulin resistance (IR) and type 2 diabetes mellitus (T2D). The NLRP3 inflamassome is a key mediator of metabolic inflammation, and it has been shown to be activated in macrophages of newly diagnosed insulin resistant-T2D patients. In humans, reduction in NLRP3 expression in adipose tissue is linked to decreased inflammation and improved insulin sensitivity in obese T2D patients. Recently, it was demonstrated that the lipolytic factor CGI-58 is an endogenous suppressor of NLRP3 activity in animal models. Therefore, the aim of this study was to evaluate CGI-58 and NLRP3 gene expressions in adipose tissue from individuals with different obesity degrees and their association with metabolic variables. …
