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Published in: Journal of Medical Systems 3/2012

01-06-2012 | ORIGINAL PAPER

Evaluation of Kidney Transplantation Programmes Using System Simulation

Authors: S. Prasanna Devi, S. Saravana Kumar, K. Suryaprakasa Rao

Published in: Journal of Medical Systems | Issue 3/2012

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Abstract

In the case of kidney transplantations, there is always a serious imbalance between the number of kidneys donated for transplantation and the number of persons wishing to receive a transplant. This not only affects the quality of life of those unable to obtain a transplant, but it also has important repercussions on the treatment of End Stage Renal Disease (ESRD) by transplantation and dialysis. Also there are a number of ways in which the kidney transplantation can be achieved, such as the cadaveric kidney transplantation, live donor kidney transplantation, kidney paired donation and list exchange. A simulation study of all the referred programmes is performed using simulation models developed for each programme to obtain the better estimate of the average waiting time of a patient per year. With the estimates given by the simulation models, the best serving programme for each blood type patient is selected, declared and recommended.
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Literature
1.
go back to reference Abecassis, M., Adams, M., and Adams, P., Consensus statement on the live organ donor. JAMA, J. Am. Med. Assoc. 284:2919–2926, 2000.CrossRef Abecassis, M., Adams, M., and Adams, P., Consensus statement on the live organ donor. JAMA, J. Am. Med. Assoc. 284:2919–2926, 2000.CrossRef
2.
go back to reference Abecassis, M., Bartlett, S. T., Collins, A. J., et al., Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference. Clin. J. Am. Soc. Nephrol. 3(2):471–480, 2008.CrossRef Abecassis, M., Bartlett, S. T., Collins, A. J., et al., Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference. Clin. J. Am. Soc. Nephrol. 3(2):471–480, 2008.CrossRef
3.
go back to reference Krakauer, H., Grauman, J. S., McMullan, M. R., and Creede, C. C., The recent U.S. experience in the treatment of end-stage renal disease by dialysis and transplantation. N Engl J. Med. 308:1558–1563, 1983.CrossRef Krakauer, H., Grauman, J. S., McMullan, M. R., and Creede, C. C., The recent U.S. experience in the treatment of end-stage renal disease by dialysis and transplantation. N Engl J. Med. 308:1558–1563, 1983.CrossRef
4.
go back to reference Mahendran, A. O., and Veitch, P. S., Paired exchange programmes can expand the live kidney pool. Br. J. Surg. 94(6):657–664, 2007.CrossRef Mahendran, A. O., and Veitch, P. S., Paired exchange programmes can expand the live kidney pool. Br. J. Surg. 94(6):657–664, 2007.CrossRef
5.
go back to reference Patel, R., and Terasaki, P. I., Significance of the positive crossmatch test in kidney transplantation. N Engl J. Med. 280:735–739, 1969.CrossRef Patel, R., and Terasaki, P. I., Significance of the positive crossmatch test in kidney transplantation. N Engl J. Med. 280:735–739, 1969.CrossRef
6.
go back to reference Rapoport, F. T. The case for a living emotionally related international kidney donor exchange registry. Transplant. Proc. 18:5–9, 1986. Rapoport, F. T. The case for a living emotionally related international kidney donor exchange registry. Transplant. Proc. 18:5–9, 1986.
7.
go back to reference Ross, L. F., and Woodle, E. S., Ethical issues in increasing living kidney donations by expanding kidney paired exchange programs. Transplantation 69:1539–1543, 2000.CrossRef Ross, L. F., and Woodle, E. S., Ethical issues in increasing living kidney donations by expanding kidney paired exchange programs. Transplantation 69:1539–1543, 2000.CrossRef
8.
go back to reference Ross, L. F., Rubin, D. T., Siegler, M., Josephson, M. A., Thistletwaite, J. R. Jr., and Woodle, E. S. Ethics of a paired kidney exchange program. N. Engl. J. Med. 336:1752–1755, 1997. Ross, L. F., Rubin, D. T., Siegler, M., Josephson, M. A., Thistletwaite, J. R. Jr., and Woodle, E. S. Ethics of a paired kidney exchange program. N. Engl. J. Med. 336:1752–1755, 1997.
9.
go back to reference Roth, A. E., Sonmez, T., and Unver, M. U., Kidney exchange. Q. J. Econ. 119:457–488, 2004.MATHCrossRef Roth, A. E., Sonmez, T., and Unver, M. U., Kidney exchange. Q. J. Econ. 119:457–488, 2004.MATHCrossRef
10.
go back to reference Roth, A. E., Sonmez, T., Unver, M. U. Pairwise kidney exchange. J. Econ. Theory, 2005 Roth, A. E., Sonmez, T., Unver, M. U. Pairwise kidney exchange. J. Econ. Theory, 2005
11.
go back to reference Roth, A. E., Sonmez, T., Unver, M. U., Delmonico, F. L., and Saidman, S. L., Utilizing list exchange & non-directed donation through ‘chain’ paired kidney donations. Am. J. Transplant. 6(11):2694–705, 2006.CrossRef Roth, A. E., Sonmez, T., Unver, M. U., Delmonico, F. L., and Saidman, S. L., Utilizing list exchange & non-directed donation through ‘chain’ paired kidney donations. Am. J. Transplant. 6(11):2694–705, 2006.CrossRef
12.
go back to reference Roth, A. E., Sonmez, T., and Unver, M. U., A kidney exchange clearing house in New England. Am Econ Rev, papers & proceeding 95:376–380, 2005.CrossRef Roth, A. E., Sonmez, T., and Unver, M. U., A kidney exchange clearing house in New England. Am Econ Rev, papers & proceeding 95:376–380, 2005.CrossRef
13.
go back to reference Rydberg, L., ABO-incompatibility in solid organ transplantation. Transfus. Med. 11:325–342, 2001.CrossRef Rydberg, L., ABO-incompatibility in solid organ transplantation. Transfus. Med. 11:325–342, 2001.CrossRef
14.
go back to reference Saidman, S. L., Roth, A. E., Sonmez, T., Unver, M. U., and Delmonico, F. L., Increasing the opportunity of live kidney donation by matching for two & three way exchanges. Transplantation 81:773–782, 2006.CrossRef Saidman, S. L., Roth, A. E., Sonmez, T., Unver, M. U., and Delmonico, F. L., Increasing the opportunity of live kidney donation by matching for two & three way exchanges. Transplantation 81:773–782, 2006.CrossRef
15.
go back to reference Segev, D. L., Gentry, S. E., Warren, D. S., Reeb, B., and Montgomery, R. A. Kidney paired donation & optimizing the use of live donor organs. J. Am. Med. Assoc., 293(15), 2005. Segev, D. L., Gentry, S. E., Warren, D. S., Reeb, B., and Montgomery, R. A. Kidney paired donation & optimizing the use of live donor organs. J. Am. Med. Assoc., 293(15), 2005.
16.
go back to reference Segev, D. L., Gentry, S. E., Keith, J., and Montgomery, R. A. Characterization of waiting times in a simulation of KPD. Am. J. Transplant. 2448–2455, 2005. Segev, D. L., Gentry, S. E., Keith, J., and Montgomery, R. A. Characterization of waiting times in a simulation of KPD. Am. J. Transplant. 2448–2455, 2005.
17.
go back to reference Vollmer, W. M., Wahl, P. W., and Blagg, C. R., Survival with dialysis and transplantation in patients with end-stage renal disease. N Engl J Med 308:1553–1558, 1983.CrossRef Vollmer, W. M., Wahl, P. W., and Blagg, C. R., Survival with dialysis and transplantation in patients with end-stage renal disease. N Engl J Med 308:1553–1558, 1983.CrossRef
Metadata
Title
Evaluation of Kidney Transplantation Programmes Using System Simulation
Authors
S. Prasanna Devi
S. Saravana Kumar
K. Suryaprakasa Rao
Publication date
01-06-2012
Publisher
Springer US
Published in
Journal of Medical Systems / Issue 3/2012
Print ISSN: 0148-5598
Electronic ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-010-9574-0

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