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Critical Care
Published in: Critical Care 1/2009

01-03-2009 | Poster presentation

Evaluation of gentamicin first-dose pharmacokinetics in septic critically ill patients: pilot study

Authors: JC Gonçalves Pereira, A Martins, P Póvoa

Published in: Critical Care | Special Issue 1/2009

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Excerpt

Aminoglycosides, especially gentamicin, are extensively used for treatment of severe infections. A dose of 7 mg/kg is recommended to achieve a high peak serum concentration. However, its accumulation is associated with adverse reactions, notably renal injury. Knowledge of gentamicin pharmacokinetics in critically ill patients is therefore crucial to therapeutic success and prevention of toxicity. …
Literature
1.
Sawchuk R, Zaske D: Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions. J Pharmacokinet Biopharm 1976, 4: 183-195. 10.1007/BF01086153PubMedCrossRef
Metadata
Title
Evaluation of gentamicin first-dose pharmacokinetics in septic critically ill patients: pilot study
Authors
JC Gonçalves Pereira
A Martins
P Póvoa
Publication date
01-03-2009
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2009
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7483

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