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Japanese Journal of Radiology

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01-07-2015 | Technical Note

Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image

Authors: Tatsuya Nishii, Atsushi K. Kono, Mizuho Nishio, Katsusuke Kyotani, Kouya Nishiyama, Kazuro Sugimura

Published in: Japanese Journal of Radiology | Issue 7/2015

Abstract

Purpose

Separate assessment of changes in blood oxygenation and blood volume is required in blood oxygen level-dependent (BOLD) imaging. We developed a calculated echo time (TE) imaging technique designed to minimize effects of blood oxygenation and to evaluate blood volume specifically.

Materials and methods

Dynamic 3T multi-echo BOLD images of calf muscle were acquired from six healthy volunteers by use of a cuff-compression model. Calculated TE images at TE = 0 ms (cTE₀) and \(T_{2}^{ * }\) map (\(T_{2}^{ * }\)) were calculated from acquired multi-echo images. The time courses of the mean value for the entire calf muscles in cTE₀, in acquired BOLD images at TE = 45.2 ms (aTE₄₅), and in \(T_{2}^{ * }\) were obtained. The Euclidean distances between the two pairs of time courses were calculated: distance between aTE₄₅ and \(T_{2}^{ * }\) (D _at), and that between cTE₀ and \(T_{2}^{ * }\) (D _ct). The difference between D _at and D _ct was tested by use of the Wilcoxon signed rank test.

Results

D _at was significantly different from D _ct (P = 0.031), indicating that the time course of cTE₀ was significantly different from that of blood oxygenation-weighted images (\(T_{2}^{ * }\) and aTE₄₅).

Conclusion

The effect of blood oxygenation could be minimized using cTE₀. Thus, signal intensity changes of cTE₀ reflected changes in blood volume more specifically.

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Title: Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image
Authors: Tatsuya Nishii
Atsushi K. Kono
Mizuho Nishio
Katsusuke Kyotani
Kouya Nishiyama
Kazuro Sugimura
Publication date: 01-07-2015
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 7/2015
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-015-0435-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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