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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2016

01-10-2016 | Maternal-Fetal Medicine

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study

Authors: Ana Cristina Perez Zamarian, Edward Araujo Júnior, Sílvia Daher, Liliam Cristine Rolo, Antonio Fernandes Moron, Luciano Marcondes Machado Nardozza

Published in: Archives of Gynecology and Obstetrics | Issue 4/2016

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Abstract

Purpose

Assessing the biochemical markers levels and the uterine artery Doppler (UtA) parameters in fetuses with growth restriction (FGR).

Methods

Prospective case–control study included 66 patients with diagnosis of FGR and 64 healthy pregnancies at 24–41 weeks of gestation. For both groups, maternal circulating concentrations of biochemical factors of soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin(sEng), adiponectin, A disintegrin and metalloproteinases (ADAM-12), pregnancy-associated plasma protein-A (PAPP-A), angiopoietin-2 (ANGI-2), vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) were assayed by ELISA and UtA by Doppler were performed. ANOVA, Mann–Whitney tests and Pearson correlation coefficient were applied to compare the biochemical factors, UtA Doppler and EFW Z-score between the groups.

Results

Concentrations of sFlt-1, sEng, PAPP-A were significantly higher in FGR than controls (p < 0.0001, p = 0.02 and p = 0.03, respectively), but concentration of ANGI-2 (p < 0.0001) was significantly lower in FGR than controls and ADAM-12 levels had a tendency to be lower in the FGR, though not statistically significant (p = 0.059). Increased sEng concentrations were correlated with abnormal UtA Doppler in FGR.

Conclusion

Fetal growth restriction fetuses showed increased serum levels of sFlt-1, sEng and PAPP-A with levels of ANGI-2 decreased and a positive association between elevated concentrations of sEng and changing impedance of UtA Doppler were observed.
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Metadata
Title
Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study
Authors
Ana Cristina Perez Zamarian
Edward Araujo Júnior
Sílvia Daher
Liliam Cristine Rolo
Antonio Fernandes Moron
Luciano Marcondes Machado Nardozza
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4024-y

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