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Clinical Neuroradiology
Published in: Clinical Neuroradiology 3/2018

01-09-2018 | Original Article

Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: A Preliminary Report

Authors: Serpil Kurtcan, Mustafa Aziz Hatiboglu, Alpay Alkan, Huseyin Toprak, Mehmet Hakan Seyithanoglu, Ayse Aralasmak, Bahar Atasoy, Omer Uysal

Published in: Clinical Neuroradiology | Issue 3/2018

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Abstract

Purpose

We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings.

Methods

In this study 13 patients with unilateral acoustic neuroma and 11 controls underwent routine magnetic resonance imaging (MRI) and DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral auditory pathways in all individuals before and after GKR.

Results

Before GKR, subjects’ ADC values obtained from the contralateral side were higher at the lateral lemniscus, medial geniculate body and Heschl’s gyrus compared to those of the controls. No statistical differences were found in ADC and FA obtained at bilateral auditory pathways before and after GKR. The ADCs measured at the lateral lemniscus were positively correlated with the maximum radiation dose delivered to the brainstem (BS) and the brainstem volume receiving a radiation dose of 10 Gy (BS V10). A negative correlation was found between the FA measured from the inferior colliculus and the maximum radiation dose to the cochlea. The ADCs at the inferior colliculus were positively correlated with the mean radiation dose to the cochlea.

Conclusion

There were no significant differences in the degree of involvement before and after GKR, revealing that GKR did not significantly affect the auditory pathways at 4 months. The major factors that may lead to microstructural injury to auditory pathways at the brainstem level are associated with maximum brainstem radiation dose, BS V10, and cochlear dose. These findings may suggest that more attention should be paid to anatomical structures including the cochlea and brainstem during treatment planning of GKR.
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Metadata
Title
Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: A Preliminary Report
Authors
Serpil Kurtcan
Mustafa Aziz Hatiboglu
Alpay Alkan
Huseyin Toprak
Mehmet Hakan Seyithanoglu
Ayse Aralasmak
Bahar Atasoy
Omer Uysal
Publication date
01-09-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 3/2018
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-017-0572-1

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