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Administration and Policy in Mental Health and Mental Health Services Research
Published in: Administration and Policy in Mental Health and Mental Health Services Research 5/2012

01-09-2012 | Original Paper

Evaluating Patient Adherence to Antidepressant Therapy Among Uninsured Working Adults Diagnosed with Major Depression: Results of the Texas Demonstration to Maintain Independence and Employment Study

Authors: Esmond D. Nwokeji, Thomas M. Bohman, Lynn Wallisch, Dena Stoner, Kristin Christensen, Richard R. Spence, Brian C. Reed, Britta Ostermeyer

Published in: Administration and Policy in Mental Health and Mental Health Services Research | Issue 5/2012

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Abstract

This study examined antidepressant adherence and persistence among uninsured working adults diagnosed with major depression enrolled in the Texas Demonstration to Maintain Independence and Employment (DMIE) program. Antidepressant adherence was measured between intervention and control cohorts using proportion of days covered (PDC) during a 365-day observation period. Persistence examined duration of time from drug initiation to discontinuation based on a ≥35-day refill supply gap. Older, non-minority patients with higher education were more adherent or persistent to antidepressant therapy. Adjusting for covariates, results showed no significant difference in PDC at the end of 12-months between intervention and control participants (b = .07, P = .054, semi-partial η 2 = .02). Exploratory analysis found subgroup differences in PDC among the study recruitment cohorts. No significant difference between intervention and control groups was found in persistence between the groups. Follow-up investigation is planned to assess the longer term impact of the DMIE program on antidepressant adherence and persistence.
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Metadata
Title
Evaluating Patient Adherence to Antidepressant Therapy Among Uninsured Working Adults Diagnosed with Major Depression: Results of the Texas Demonstration to Maintain Independence and Employment Study
Authors
Esmond D. Nwokeji
Thomas M. Bohman
Lynn Wallisch
Dena Stoner
Kristin Christensen
Richard R. Spence
Brian C. Reed
Britta Ostermeyer
Publication date
01-09-2012
Publisher
Springer US
Published in
Administration and Policy in Mental Health and Mental Health Services Research / Issue 5/2012
Print ISSN: 0894-587X
Electronic ISSN: 1573-3289
DOI
https://doi.org/10.1007/s10488-011-0354-z

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