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01-11-2014 | Autism Spectrum Disorders (ES Brodkin, Section Editor)

Etiology of Autism Spectrum Disorder: A Genomics Perspective

Authors: John J. Connolly, Hakon Hakonarson

Published in: Current Psychiatry Reports | Issue 11/2014

Abstract

In recent years, considerable progress has been made in understanding the genomic basis of autism spectrum disorder (ASD). Hundreds of variants have been proposed as predisposing to ASD, and the challenge now is to validate candidates and to understand how gene networks interact to produce ASD phenotypes. Genome-wide association and second-generation sequencing studies in particular have provided important indications about how to understand ASD on a molecular level, and we are beginning to see these experimental approaches translate into novel treatments and diagnostic tests. We review key studies in the field over the past five years and discuss some of the remaining technological and methodological challenges that remain.

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Title: Etiology of Autism Spectrum Disorder: A Genomics Perspective
Authors: John J. Connolly
Hakon Hakonarson
Publication date: 01-11-2014
Publisher: Springer US
Published in: Current Psychiatry Reports / Issue 11/2014
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-014-0501-9

At a glance: The STEP trials

Springer Medicine

Etiology of Autism Spectrum Disorder: A Genomics Perspective

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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