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Published in: Clinical Orthopaedics and Related Research® 7/2009

01-07-2009 | Original Article

Etiology of Ankle Osteoarthritis

Authors: Victor Valderrabano, MD, PhD, Monika Horisberger, MD, Iain Russell, MD, Hugh Dougall, MD, Beat Hintermann, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 7/2009

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Abstract

The purpose of this study was to evaluate the distribution rate of etiologies leading to ankle arthritis and to quantify and compare the important clinical and radiologic variables among these etiologic groups. We evaluated data from 390 patients (406 ankles) who consulted our center because of painful end-stage ankle osteoarthritis (OA) by using medical history, physical examination, and radiography. Posttraumatic ankle OA was seen in 78% of the cases (n = 318), secondary arthritis in 13% (n = 52), and primary OA in 9% (n = 36). The average American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score was 38 points (range, 0–74 points), range of motion was 22° (range, 0°−65°), and visual analog scale for pain was 6.8 (range, 2–10). Patients with posttraumatic end-stage ankle OA were younger than patients with primary OA. The average tibiotalar alignment was 88° (range, 51°–116°) and did not differ between the etiologic groups. Our study showed trauma is the main cause of ankle OA and primary OA is rare. In the majority of patients with ankle OA the average tibiotalar alignment is varus regardless of the underlying etiology.
Level of Evidence: Level IV, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.
Literature
1.
go back to reference Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA. Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum. 2005;52:112–119.PubMedCrossRef Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA. Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum. 2005;52:112–119.PubMedCrossRef
2.
go back to reference Brown TD, Shaw DT. In vitro contact stress distributions in the natural human hip. J Biomech. 1983;16:373–384.PubMedCrossRef Brown TD, Shaw DT. In vitro contact stress distributions in the natural human hip. J Biomech. 1983;16:373–384.PubMedCrossRef
3.
go back to reference Coester LM, Saltzman CL, Leupold J, Pontarelli W. Long-term results following ankle arthrodesis for post-traumatic arthritis. J Bone Joint Surg Am. 2001;83:219–228.PubMed Coester LM, Saltzman CL, Leupold J, Pontarelli W. Long-term results following ankle arthrodesis for post-traumatic arthritis. J Bone Joint Surg Am. 2001;83:219–228.PubMed
4.
go back to reference DeCoster TA, Willis MC, Marsh JL, Williams TM, Nepola JV, Dirschl DR, Hurwitz SR. Rank order analysis of tibial plafond fractures: does injury or reduction predict outcome? Foot Ankle Int. 1999;20:44–49.PubMed DeCoster TA, Willis MC, Marsh JL, Williams TM, Nepola JV, Dirschl DR, Hurwitz SR. Rank order analysis of tibial plafond fractures: does injury or reduction predict outcome? Foot Ankle Int. 1999;20:44–49.PubMed
5.
go back to reference Eger W, Schumacher BL, Mollenhauer J, Kuettner KE, Cole AA. Human knee and ankle cartilage explants: catabolic differences. J Orthop Res. 2002;20:526–534.PubMedCrossRef Eger W, Schumacher BL, Mollenhauer J, Kuettner KE, Cole AA. Human knee and ankle cartilage explants: catabolic differences. J Orthop Res. 2002;20:526–534.PubMedCrossRef
6.
go back to reference Elgafy H, Ebraheim NA, Tile M, Stephen D, Kase J. Fractures of the talus: experience of two level 1 trauma centers. Foot Ankle Int. 2000;21:1023–1029.PubMed Elgafy H, Ebraheim NA, Tile M, Stephen D, Kase J. Fractures of the talus: experience of two level 1 trauma centers. Foot Ankle Int. 2000;21:1023–1029.PubMed
7.
go back to reference Felson DT. The epidemiology of osteoarthritis: prevalence and risk factors. In: Kuettner KE, Goldberg VM, eds. Osteoarthritis Disorders. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1995:13–24. Felson DT. The epidemiology of osteoarthritis: prevalence and risk factors. In: Kuettner KE, Goldberg VM, eds. Osteoarthritis Disorders. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1995:13–24.
8.
go back to reference Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 2000;133:321–328.PubMed Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 2000;133:321–328.PubMed
9.
go back to reference Gunther KP, Sturmer T, Sauerland S, Zeissig I, Sun Y, Kessler S, Scharf HP, Brenner H, Puhl W. Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. Ann Rheum Dis. 1998;57:717–723.PubMedCrossRef Gunther KP, Sturmer T, Sauerland S, Zeissig I, Sun Y, Kessler S, Scharf HP, Brenner H, Puhl W. Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. Ann Rheum Dis. 1998;57:717–723.PubMedCrossRef
10.
go back to reference Harrington KD. Degenerative arthritis of the ankle secondary to long-standing lateral ligament instability. J Bone Joint Surg Am. 1979;61:354–361.PubMed Harrington KD. Degenerative arthritis of the ankle secondary to long-standing lateral ligament instability. J Bone Joint Surg Am. 1979;61:354–361.PubMed
11.
go back to reference Hashimoto T, Inokuchi S. A kinematic study of ankle joint instability due to rupture of the lateral ligaments. Foot Ankle Int. 1997;18:729–734.PubMed Hashimoto T, Inokuchi S. A kinematic study of ankle joint instability due to rupture of the lateral ligaments. Foot Ankle Int. 1997;18:729–734.PubMed
12.
go back to reference Huch K, Kuettner KE, Dieppe P. Osteoarthritis in ankle and knee joints. Semin Arthritis Rheum. 1997;26:667–674.PubMedCrossRef Huch K, Kuettner KE, Dieppe P. Osteoarthritis in ankle and knee joints. Semin Arthritis Rheum. 1997;26:667–674.PubMedCrossRef
13.
go back to reference Ihn JC, Kim SJ, Park IH. In vitro study of contact area and pressure distribution in the human knee after partial and total meniscectomy. Int Orthop. 1993;17:214–218.PubMedCrossRef Ihn JC, Kim SJ, Park IH. In vitro study of contact area and pressure distribution in the human knee after partial and total meniscectomy. Int Orthop. 1993;17:214–218.PubMedCrossRef
14.
go back to reference Jaakkola JI, Mann RA. A review of rheumatoid arthritis affecting the foot and ankle. Foot Ankle Int. 2004;25:866–874.PubMed Jaakkola JI, Mann RA. A review of rheumatoid arthritis affecting the foot and ankle. Foot Ankle Int. 2004;25:866–874.PubMed
15.
go back to reference Kang Y, Koepp H, Cole AA, Kuettner KE, Homandberg GA. Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments. J Orthop Res. 1998;16:551–556.PubMedCrossRef Kang Y, Koepp H, Cole AA, Kuettner KE, Homandberg GA. Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments. J Orthop Res. 1998;16:551–556.PubMedCrossRef
16.
go back to reference Kimizuka M, Kurosawa H, Fukubayashi T. Load-bearing pattern of the ankle joint: contact area and pressure distribution. Arch Orthop Trauma Surg. 1980;96:45–49.PubMedCrossRef Kimizuka M, Kurosawa H, Fukubayashi T. Load-bearing pattern of the ankle joint: contact area and pressure distribution. Arch Orthop Trauma Surg. 1980;96:45–49.PubMedCrossRef
17.
go back to reference Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15:349–353.PubMed Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15:349–353.PubMed
18.
go back to reference Knupp M, Ledermann H, Magerkurth O, Hinterman B. The surgical tibiotalar angle: a radiologic study. Foot Ankle Int. 2005;26:713–716.PubMed Knupp M, Ledermann H, Magerkurth O, Hinterman B. The surgical tibiotalar angle: a radiologic study. Foot Ankle Int. 2005;26:713–716.PubMed
19.
go back to reference Koralewicz LM, Engh GA. Comparison of proprioception in arthritic and age-matched normal knees. J Bone Joint Surg Am. 2000;82:1582–1588.PubMed Koralewicz LM, Engh GA. Comparison of proprioception in arthritic and age-matched normal knees. J Bone Joint Surg Am. 2000;82:1582–1588.PubMed
20.
go back to reference Lindsjö U. Operative treatment of ankle fracture-dislocations: a follow-up study of 306/321 consecutive cases. Clin Orthop Relat Res. 1985;199:28–38.PubMed Lindsjö U. Operative treatment of ankle fracture-dislocations: a follow-up study of 306/321 consecutive cases. Clin Orthop Relat Res. 1985;199:28–38.PubMed
21.
go back to reference Lofvenberg R, Karrholm J, Lund B. The outcome of nonoperated patients with chronic lateral instability of the ankle: a 20-year follow-up study. Foot Ankle Int. 1994;15:165–169.PubMed Lofvenberg R, Karrholm J, Lund B. The outcome of nonoperated patients with chronic lateral instability of the ankle: a 20-year follow-up study. Foot Ankle Int. 1994;15:165–169.PubMed
22.
go back to reference Marsh JL, Buckwalter J, Gelberman R, Dirschl D, Olson S, Brown T, Llinias A. Articular fractures: does an anatomic reduction really change the result? J Bone Joint Surg Am. 2002;84:1259–1271.PubMed Marsh JL, Buckwalter J, Gelberman R, Dirschl D, Olson S, Brown T, Llinias A. Articular fractures: does an anatomic reduction really change the result? J Bone Joint Surg Am. 2002;84:1259–1271.PubMed
23.
go back to reference Martin JA, Ellerbroek SM, Buckwalter JA. Age-related decline in chondrocyte response to insulin-like growth factor: I. The role of growth factor binding proteins. J Orthop Res. 1997;15:491–498.PubMedCrossRef Martin JA, Ellerbroek SM, Buckwalter JA. Age-related decline in chondrocyte response to insulin-like growth factor: I. The role of growth factor binding proteins. J Orthop Res. 1997;15:491–498.PubMedCrossRef
24.
go back to reference Melton LJ III, Khosla S, Crowson CS, O’Connor MK, O’Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000;48:625–630.PubMed Melton LJ III, Khosla S, Crowson CS, O’Connor MK, O’Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000;48:625–630.PubMed
25.
go back to reference Monroe MT, Beals TC, Manoli A. Clinical outcome of arthrodesis of the ankle using rigid internal fixation with cancellous screws. Foot Ankle Int. 1999;20:227–231.PubMed Monroe MT, Beals TC, Manoli A. Clinical outcome of arthrodesis of the ankle using rigid internal fixation with cancellous screws. Foot Ankle Int. 1999;20:227–231.PubMed
26.
go back to reference Mont MA, Sedlin ED, Weiner LS, Miller AR. Postoperative radiographs as predictors of clinical outcome in unstable ankle fractures. J Orthop Trauma. 1992;6:352–357.PubMedCrossRef Mont MA, Sedlin ED, Weiner LS, Miller AR. Postoperative radiographs as predictors of clinical outcome in unstable ankle fractures. J Orthop Trauma. 1992;6:352–357.PubMedCrossRef
27.
go back to reference Morrey BF, Wiedeman GP Jr. Complications and long-term results of ankle arthrodeses following trauma. J Bone Joint Surg Am. 1980;62:777–784.PubMed Morrey BF, Wiedeman GP Jr. Complications and long-term results of ankle arthrodeses following trauma. J Bone Joint Surg Am. 1980;62:777–784.PubMed
28.
go back to reference Okuda R, Kinoshita M, Morikawa J, Yasuda T, Abe M. Arthroscopic findings in chronic lateral ankle instability: do focal chondral lesions influence the results of ligament reconstruction? Am J Sports Med. 2005;33:35–42.PubMedCrossRef Okuda R, Kinoshita M, Morikawa J, Yasuda T, Abe M. Arthroscopic findings in chronic lateral ankle instability: do focal chondral lesions influence the results of ligament reconstruction? Am J Sports Med. 2005;33:35–42.PubMedCrossRef
29.
go back to reference Peyron JG. The epidemiology of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis. Diagnosis and Treatment. Philadelphia, PA: WB Saunders; 1984:9–27. Peyron JG. The epidemiology of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis. Diagnosis and Treatment. Philadelphia, PA: WB Saunders; 1984:9–27.
30.
go back to reference Phillips WA, Schwartz HS, Keller CS, Woodward HR, Rudd WS, Spiegel PG, Laros GS. A prospective, randomized study of the management of severe ankle fractures. J Bone Joint Surg Am. 1985;67:67–78.PubMed Phillips WA, Schwartz HS, Keller CS, Woodward HR, Rudd WS, Spiegel PG, Laros GS. A prospective, randomized study of the management of severe ankle fractures. J Bone Joint Surg Am. 1985;67:67–78.PubMed
31.
go back to reference Puno RM, Vaughan JJ, Stetten ML, Johnson JR. Long-term effects of tibial angular malunion on the knee and ankle joints. J Orthop Trauma. 1991;5:247–254.PubMedCrossRef Puno RM, Vaughan JJ, Stetten ML, Johnson JR. Long-term effects of tibial angular malunion on the knee and ankle joints. J Orthop Trauma. 1991;5:247–254.PubMedCrossRef
32.
go back to reference Ruedi T. Fractures of the lower end of the tibia into the ankle joint: results 9 years after open reduction and internal fixation. Injury. 1973;5:130–134.PubMedCrossRef Ruedi T. Fractures of the lower end of the tibia into the ankle joint: results 9 years after open reduction and internal fixation. Injury. 1973;5:130–134.PubMedCrossRef
33.
go back to reference Saltzman CL, Salamon ML, Blanchard GM, Huff T, Hayes A, Buckwalter JA, Amendola A. Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center. Iowa Orthop J. 2005;25:44–46.PubMed Saltzman CL, Salamon ML, Blanchard GM, Huff T, Hayes A, Buckwalter JA, Amendola A. Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center. Iowa Orthop J. 2005;25:44–46.PubMed
34.
go back to reference Seitz WH, Andrews DL, Shelton ML, Feldman F. Triplane fractures of the adolescent ankle: a report of three cases. Injury. 1985;16:547–553.PubMedCrossRef Seitz WH, Andrews DL, Shelton ML, Feldman F. Triplane fractures of the adolescent ankle: a report of three cases. Injury. 1985;16:547–553.PubMedCrossRef
35.
go back to reference Shepherd DE, Seedhom BB. Thickness of human articular cartilage in joints of the lower limb. Ann Rheum Dis. 1999;58:27–34.PubMedCrossRef Shepherd DE, Seedhom BB. Thickness of human articular cartilage in joints of the lower limb. Ann Rheum Dis. 1999;58:27–34.PubMedCrossRef
36.
go back to reference Stamatis ED, Cooper PS, Myerson MS. Supramalleolar osteotomy for the treatment of distal tibial angular deformities and arthritis of the ankle joint. Foot Ankle Int. 2003;24:754–764.PubMed Stamatis ED, Cooper PS, Myerson MS. Supramalleolar osteotomy for the treatment of distal tibial angular deformities and arthritis of the ankle joint. Foot Ankle Int. 2003;24:754–764.PubMed
37.
go back to reference Stauffer RN, Chao EY, Brewster RC. Force and motion analysis of the normal, diseased, and prosthetic ankle joint. Clin Orthop Relat Res. 1977;127:189–196.PubMed Stauffer RN, Chao EY, Brewster RC. Force and motion analysis of the normal, diseased, and prosthetic ankle joint. Clin Orthop Relat Res. 1977;127:189–196.PubMed
38.
go back to reference Taga I, Shino K, Inoue M, Nakata K, Maeda A. Articular cartilage lesions in ankles with lateral ligament injury: an arthroscopic study. Am J Sports Med. 1993;21:120–126.PubMedCrossRef Taga I, Shino K, Inoue M, Nakata K, Maeda A. Articular cartilage lesions in ankles with lateral ligament injury: an arthroscopic study. Am J Sports Med. 1993;21:120–126.PubMedCrossRef
39.
go back to reference Takakura Y, Takaoka T, Tanaka Y, Yajima H, Tamai S. Results of opening-wedge osteotomy for the treatment of a post-traumatic varus deformity of the ankle. J Bone Joint Surg Am. 1998;80:213–218.PubMedCrossRef Takakura Y, Takaoka T, Tanaka Y, Yajima H, Tamai S. Results of opening-wedge osteotomy for the treatment of a post-traumatic varus deformity of the ankle. J Bone Joint Surg Am. 1998;80:213–218.PubMedCrossRef
40.
go back to reference Thomas RH, Daniels TR. Current concepts review: ankle arthritis. J Bone Joint Surg Am. 2003;85:923–936.PubMed Thomas RH, Daniels TR. Current concepts review: ankle arthritis. J Bone Joint Surg Am. 2003;85:923–936.PubMed
41.
go back to reference Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J Orthop Res. 2000;18:739–748.PubMedCrossRef Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J Orthop Res. 2000;18:739–748.PubMedCrossRef
42.
go back to reference Wyrsch B, McFerran MA, McAndrew M, Limbird TJ, Harper MC, Johnson KD, Schwartz HS. Operative treatment of fractures of the tibial plafond: a randomized, prospective study. J Bone Joint Surg Am. 1996;78:1646–1657.PubMed Wyrsch B, McFerran MA, McAndrew M, Limbird TJ, Harper MC, Johnson KD, Schwartz HS. Operative treatment of fractures of the tibial plafond: a randomized, prospective study. J Bone Joint Surg Am. 1996;78:1646–1657.PubMed
43.
go back to reference Wyss C, Zollinger H. The causes of subsequent arthrodesis of the ankle joint. Acta Orthop Belg. 1991;57(suppl 1):22–27.PubMed Wyss C, Zollinger H. The causes of subsequent arthrodesis of the ankle joint. Acta Orthop Belg. 1991;57(suppl 1):22–27.PubMed
Metadata
Title
Etiology of Ankle Osteoarthritis
Authors
Victor Valderrabano, MD, PhD
Monika Horisberger, MD
Iain Russell, MD
Hugh Dougall, MD
Beat Hintermann, MD
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 7/2009
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-008-0543-6

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