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Published in: Head & Neck Oncology 1/2012

Open Access 01-12-2012 | Case report

Etiology analysis and computed tomography imaging of a tonsillar inflammatory myofibroblastic tumor: report of an immunocompetent patient and brief review

Authors: Yun-Zhen Luo, Li-Bo Dai, Shui-Hong Zhou, Xing-Mei Luo, Jun Fan, Ling-Xiang Ruan

Published in: Head & Neck Oncology | Issue 1/2012

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Abstract

Objectives

The etiology of Inflammatory myofibroblastic tumor(IMT) is contentious. In this study, we used computed tomography (CT) to examine tonsillar IMT and further analyzed the etiology of this entity.

Methodology

We presented CT features of left tonsillar IMT and reviewed the English-language literature published between 1984 and 2011.

Results

To our knowledge, there are only six published cases of tonsillar IMT including the present case. Two patients were asymptomatic at initial presentation. Two patients were taking immunosuppressants, and one was pregnant and in an immunomodulated state. CT of our patient revealed a 2.6 × 1.8 cm irregular soft tissue mass between the left tonsil and the base of the tongue. It did not invade surrounding structures and was not enhanced on contrast-enhanced imaging.

Conclusions

Tonsillar IMT may be a benign tumor. We suggest that preoperative recognition of tonsillar IMT by CT may be important to avoid unnecessary expanded surgery.
Appendix
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Literature
1.
go back to reference Saab ST, Hornick JL, Fletcher CD, Olson SJ, Coffin CM: IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link. Mod Pathol. 2011, 24: 606-612. 10.1038/modpathol.2010.226.CrossRefPubMed Saab ST, Hornick JL, Fletcher CD, Olson SJ, Coffin CM: IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link. Mod Pathol. 2011, 24: 606-612. 10.1038/modpathol.2010.226.CrossRefPubMed
2.
go back to reference Lu CH, Huang HY, Chen HK, Chuang JH, Ng SH, Ko SF: Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy. World J Gastroenterol. 2010, 16: 2698-2701. 10.3748/wjg.v16.i21.2698.PubMedCentralCrossRefPubMed Lu CH, Huang HY, Chen HK, Chuang JH, Ng SH, Ko SF: Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy. World J Gastroenterol. 2010, 16: 2698-2701. 10.3748/wjg.v16.i21.2698.PubMedCentralCrossRefPubMed
3.
go back to reference Song Z, Zhang Y, Xu X, Li F, Shi T, Li Z, Zhou Q: Inflammatory myofibroblastic tumor invading pulmonary trunk with multiple mediastinal lymph node metastasis. Ann Thorac Surg. 2011, 92: e15-10.1016/j.athoracsur.2011.04.097.CrossRefPubMed Song Z, Zhang Y, Xu X, Li F, Shi T, Li Z, Zhou Q: Inflammatory myofibroblastic tumor invading pulmonary trunk with multiple mediastinal lymph node metastasis. Ann Thorac Surg. 2011, 92: e15-10.1016/j.athoracsur.2011.04.097.CrossRefPubMed
4.
go back to reference Graefe H, Stellmacher F, Sotlar K, Wollenberg B, Gehrking E: Inflammatory pseudotumor of the hypopharynx: clinical diagnosis, immunohistochemical findings and treatment of this rare disease. In Vivo. 2008, 22: 817-820.PubMed Graefe H, Stellmacher F, Sotlar K, Wollenberg B, Gehrking E: Inflammatory pseudotumor of the hypopharynx: clinical diagnosis, immunohistochemical findings and treatment of this rare disease. In Vivo. 2008, 22: 817-820.PubMed
5.
go back to reference Sanahuja J, Ordoñez-Palau S, Begué R, Brieva L, Boquet D: Primary Sjögren Syndrome with tumefactive central nervous system involvement. AJNR Am J Neuroradiol. 2008, 29: 1878-1879. 10.3174/ajnr.A1204.CrossRefPubMed Sanahuja J, Ordoñez-Palau S, Begué R, Brieva L, Boquet D: Primary Sjögren Syndrome with tumefactive central nervous system involvement. AJNR Am J Neuroradiol. 2008, 29: 1878-1879. 10.3174/ajnr.A1204.CrossRefPubMed
6.
go back to reference Zheng Z, Pan Y, Pan T, Li J: Coexistent pulmonary inflammatory pseudotumor and carcinoma in one patient: does positron emission tomography/computed tomography help. Ann Thorac Surg. 2011, 91: e43-10.1016/j.athoracsur.2010.12.006.CrossRefPubMed Zheng Z, Pan Y, Pan T, Li J: Coexistent pulmonary inflammatory pseudotumor and carcinoma in one patient: does positron emission tomography/computed tomography help. Ann Thorac Surg. 2011, 91: e43-10.1016/j.athoracsur.2010.12.006.CrossRefPubMed
7.
go back to reference Coffin CM, Hornick JL, Fletcher CD: Inflammatory myofibroblastic tumor comparison of clinicopathologic, hstologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007, 31: 509-520. 10.1097/01.pas.0000213393.57322.c7.CrossRefPubMed Coffin CM, Hornick JL, Fletcher CD: Inflammatory myofibroblastic tumor comparison of clinicopathologic, hstologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007, 31: 509-520. 10.1097/01.pas.0000213393.57322.c7.CrossRefPubMed
8.
go back to reference Binmadi NO, Packman H, Papadimitriou JC, Scheper M: Oral inflammatory myofibroblastic tumor: case report and review of literature. Open Dent J. 2011, 5: 66-70. 10.2174/1874210601105010066.PubMedCentralCrossRefPubMed Binmadi NO, Packman H, Papadimitriou JC, Scheper M: Oral inflammatory myofibroblastic tumor: case report and review of literature. Open Dent J. 2011, 5: 66-70. 10.2174/1874210601105010066.PubMedCentralCrossRefPubMed
9.
go back to reference Grube-Pagola P, Carrasco-Daza D, Alderete-Vázquez G, Gutiérrez-Butanda J: Inflammatory myofibroblastic tumour of the tonsil: case report and literature review. Acta Otorrinolaringol Esp. 2011, [Epub ahead of print] in press Grube-Pagola P, Carrasco-Daza D, Alderete-Vázquez G, Gutiérrez-Butanda J: Inflammatory myofibroblastic tumour of the tonsil: case report and literature review. Acta Otorrinolaringol Esp. 2011, [Epub ahead of print] in press
10.
go back to reference Magill JC, Ferguson MS, Butler CR, Sandison A, Grant WE: Inflammatory myofibroblastic tumour of the tonsil: case report and literature review. J Laryngol Otol. 2010, 124: 1123-1125. 10.1017/S0022215110000058.CrossRefPubMed Magill JC, Ferguson MS, Butler CR, Sandison A, Grant WE: Inflammatory myofibroblastic tumour of the tonsil: case report and literature review. J Laryngol Otol. 2010, 124: 1123-1125. 10.1017/S0022215110000058.CrossRefPubMed
11.
go back to reference Gangopadhyay K, Mahasin ZZ, Kfoury H, Ali MA: Inflammatory myofibroblastic tumour of the tonsil. J Laryngol Otol. 1997, 111: 880-882.PubMed Gangopadhyay K, Mahasin ZZ, Kfoury H, Ali MA: Inflammatory myofibroblastic tumour of the tonsil. J Laryngol Otol. 1997, 111: 880-882.PubMed
12.
go back to reference Newman JP, Shinn JB: Inflammatory pseudotumour of the tonsil. Otolaryngol Head Neck Surg. 1995, 113: 798-801. 10.1016/S0194-5998(95)70025-0.CrossRefPubMed Newman JP, Shinn JB: Inflammatory pseudotumour of the tonsil. Otolaryngol Head Neck Surg. 1995, 113: 798-801. 10.1016/S0194-5998(95)70025-0.CrossRefPubMed
13.
go back to reference Weilbaecher TG, Sharma DP: Plasma cell granuloma of the tonsil. J Surg Oncol. 1984, 27: 228-231. 10.1002/jso.2930270406.CrossRefPubMed Weilbaecher TG, Sharma DP: Plasma cell granuloma of the tonsil. J Surg Oncol. 1984, 27: 228-231. 10.1002/jso.2930270406.CrossRefPubMed
14.
go back to reference Androulaki A, Papathomas TG, Liapis G, Papaconstantinou I, Gazouli M, Goutas N, Bramis K, Papalambros A, Lazaris AC, Papalambros E: Inflammatory pseudotumor associated with Mycobacterium tuberculosis infection. Int J Infect Dis. 2008, 12: 607-610. 10.1016/j.ijid.2007.12.011.CrossRefPubMed Androulaki A, Papathomas TG, Liapis G, Papaconstantinou I, Gazouli M, Goutas N, Bramis K, Papalambros A, Lazaris AC, Papalambros E: Inflammatory pseudotumor associated with Mycobacterium tuberculosis infection. Int J Infect Dis. 2008, 12: 607-610. 10.1016/j.ijid.2007.12.011.CrossRefPubMed
15.
go back to reference Perera MT, Wijesuriya SR, Kumarage SK, Ariyaratne MH, Deen KI: Inflammatory pseudotumour of the liver caused by a migrated fish bone. Ceylon Med J. 2007, 52: 141-142.PubMed Perera MT, Wijesuriya SR, Kumarage SK, Ariyaratne MH, Deen KI: Inflammatory pseudotumour of the liver caused by a migrated fish bone. Ceylon Med J. 2007, 52: 141-142.PubMed
16.
go back to reference Gonzalez-Duarte A, Sullivan S, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano I, Mullen M, Simpson D: Inflammatory pseudotumor associated with HIV, JCV, and immune reconstitution syndrome. Neurology. 2009, 72: 289-290. 10.1212/01.wnl.0000339488.32588.0f.PubMedCentralCrossRefPubMed Gonzalez-Duarte A, Sullivan S, Sips GJ, Naidich T, Kleinman G, Murray J, Morgello S, Germano I, Mullen M, Simpson D: Inflammatory pseudotumor associated with HIV, JCV, and immune reconstitution syndrome. Neurology. 2009, 72: 289-290. 10.1212/01.wnl.0000339488.32588.0f.PubMedCentralCrossRefPubMed
17.
go back to reference Kiryu S, Takeuchi K, Shibahara J, Uozaki H, Fukayama M, Tanaka H, Maeda E, Akahane M, Ohtomo K: Epstein-Barrvirus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour. Br J Radiol. 2009, 82: e67-e71.CrossRefPubMed Kiryu S, Takeuchi K, Shibahara J, Uozaki H, Fukayama M, Tanaka H, Maeda E, Akahane M, Ohtomo K: Epstein-Barrvirus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour. Br J Radiol. 2009, 82: e67-e71.CrossRefPubMed
18.
go back to reference Yamrubboon W, Phongkitkarun S, Jaovisidha S, Sirikulchayanonta V, Tapaneeyakorn J, Siripornpitak S: Inflammatory myofibroblastic tumor ofabdomen: computerized tomographic (CT) and pathological findings. J Med Assoc Thai. 2008, 91: 1487-1493.PubMed Yamrubboon W, Phongkitkarun S, Jaovisidha S, Sirikulchayanonta V, Tapaneeyakorn J, Siripornpitak S: Inflammatory myofibroblastic tumor ofabdomen: computerized tomographic (CT) and pathological findings. J Med Assoc Thai. 2008, 91: 1487-1493.PubMed
19.
go back to reference Gleason BC, Hornick JL: Inflammatory myofibroblastic tumours: where are we now?. J Clin Pathol. 2008, 61: 428-437. 10.1136/jcp.2007.049387.CrossRefPubMed Gleason BC, Hornick JL: Inflammatory myofibroblastic tumours: where are we now?. J Clin Pathol. 2008, 61: 428-437. 10.1136/jcp.2007.049387.CrossRefPubMed
20.
go back to reference Zhou SH, Ruan LX, Xu YY, Wang SQ, Ren GP, Ling L: Inflammatory myofibroblastic tumour in the left maxillary sinus: a case report. Chin Med J. 2004, 117: 1597-1599. (Engl)PubMed Zhou SH, Ruan LX, Xu YY, Wang SQ, Ren GP, Ling L: Inflammatory myofibroblastic tumour in the left maxillary sinus: a case report. Chin Med J. 2004, 117: 1597-1599. (Engl)PubMed
Metadata
Title
Etiology analysis and computed tomography imaging of a tonsillar inflammatory myofibroblastic tumor: report of an immunocompetent patient and brief review
Authors
Yun-Zhen Luo
Li-Bo Dai
Shui-Hong Zhou
Xing-Mei Luo
Jun Fan
Ling-Xiang Ruan
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2012
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-4-4

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