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01-11-2014 | Review Article

Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity

Authors: Yu-Long Lan, Jie Zhao, Shao Li

Published in: Neurological Sciences | Issue 11/2014

Abstract

Glutamate is the most abundant excitatory brain neurotransmitter that has important functional significance with respect to neurodegenerative conditions. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease (AD) has been gradually becoming elucidated recently. Excessive release of glutamate induces an increase in intracellular Ca²⁺ levels, thus triggers a cascade of cellular responses, ultimately leading to neuronal cell death. This type of neuronal damage induced by over-excitation has been proposed to be involved in a number of neuropathological conditions, ranging from acute insults to chronic neurodegenerative disorders. Estrogen could be effective in modulating glutamate-induced neurotoxicity and the protective responsivenesses are mostly estrogen receptors (ERs)-dependent. However, the mechanism underlying estrogen’s neuroprotective effect is not fully clarified and is complicated by the presence of several distinct ER types. So a deeper research into the neuroprotection of ERs might be informative about the positive effect that estrogen might have on ageing-related cognitive changes. Extensive studies have indicated the neuroprotective effects of ERs against glutamate-induced neurotoxicity. The purpose of this review is to elucidate ERs’ neuroprotective effects against glutamate-induced cytotoxicity and explore new ways to prevent and cure neurotoxicity-associated neurodegenerative disorders.

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Title: Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity
Authors: Yu-Long Lan
Jie Zhao
Shao Li
Publication date: 01-11-2014
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 11/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1937-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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