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BMC Oral Health
Published in: BMC Oral Health 1/2022

Open Access 01-12-2022 | Research

Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep

Authors: Qianwen Yin, Chao Liu, Han Bao, Size Li, Zhuwei Huang, Deao Gu, Liping Xiong, Leiying Miao

Published in: BMC Oral Health | Issue 1/2022

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Abstract

Background

Sleep is crucial for survival. Sleep deprivation causes ROS accumulation and, consequently, oxidative stress. The goal of the study was to evaluate gingival crevicular fluid (GCF) levels of the oxidative stress status hydrogen peroxide (H2O2), superoxide glutathione (GSH), and cellular oxidative damage marker malondialdehyde (MDA) in school-aged children and teenagers with insufficient sleep.

Methods

This study investigated sleep duration in 80 participants from two different developmental stages: school-aged children (6–13 years) and teenagers (14–17 years). GCF samples were obtained from all individuals, and samples were investigated to detect H2O2, GSH, and MDA levels using the micro method.

Results

Results reveal that GCF MDA and H2O2 in school-age children and teenagers with insufficient sleep were significantly higher than in children with sufficient sleep. GCF GSH with insufficient sleep was insignificantly lower than in children with sufficient sleep. There was no significant difference between school-age and teenage populations.

Conclusion

Sleep deprivation causes increased levels of oxidative stress in gingival crevicular fluid, and adequate sleep is essential for maintaining redox balance.
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Metadata
Title
Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep
Authors
Qianwen Yin
Chao Liu
Han Bao
Size Li
Zhuwei Huang
Deao Gu
Liping Xiong
Leiying Miao
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2022
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-022-02642-z

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