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Obesity Surgery
Published in: Obesity Surgery 6/2016

01-06-2016 | Original Contributions

Essential Fatty Acid Plasma Profiles Following Gastric Bypass and Adjusted Gastric Banding Bariatric Surgeries

Authors: Rebekah Forbes, Danijela Gasevic, Emily M. Watson, Thomas R. Ziegler, Edward Lin, John R. Burgess, Nana Gletsu-Miller

Published in: Obesity Surgery | Issue 6/2016

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Abstract

Background

Although patients experience hair loss and dry skin which may be attributable to deficiency in essential fatty acids (EFAs), the impact of bariatric surgeries on EFA status is unknown.

Methods

This study aimed to assess plasma phospholipid fatty acid profiles following adjustable gastric banding (AGB), which restricts dietary fat intake, versus Roux-en-Y gastric bypass (RYGB), which also promotes fat malabsorption. Serial measures were obtained before and 1 and 6 months from women undergoing RYGB (N = 13) and AGB (N = 5). Measures included the composition of plasma fatty acids in phospholipids, dietary intake, and body fat mass. Friedman and Mann–Whitney tests were used to assess differences over time and between groups, respectively, p < 0.05.

Results

Dietary intake of fats decreased equally at 1 and 6 months following RYGB and AGB. By 6 months, the RYGB group lost more body fat. There were no remarkable changes in EFA in plasma phospholipids following AGB. However, following RYGB, a transient increase in 20:4N6 (+18 %) and a decrease in 20:3N6 at 1 (−47 %) and 6 months (−47 %) were observed. Similar changes were observed in N3 fatty acids following RYGB, including a transient increase in 22:6N3 (+11 %) and decreases in 20:5N3 (−79 and −67 % at 1 and 6 months, respectively). EFA status improved following surgery in the RYGB group.

Conclusions

We demonstrate alterations in plasma EFA following RYGB. The status of EFA improved, but the decrease in 20:5N3, the precursor for anti-inflammatory eicosanoids, may be a concern.
Literature
1.
Holman RT, Johnson SB, Hatch TF. A case of human linolenic acid deficiency involving neurological abnormalities. Am J Clin Nutr. 1982;35:617–23.PubMed
2.
Davis BC, Kris-Etherton PM. Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am J Clin Nutr. 2003;78:640–6.
3.
Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta 6, delta 5, and delta 9 desaturates. Annu Rev Nutr. 2004;24:345–76.CrossRefPubMed
4.
Araya J, Rodrigo R, Pettinelli P, et al. Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients. Obesity (Silver Spring). 2010;18:1460–3.CrossRef
5.
Brignardello J, Morales P, Diaz E, et al. Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. Arch Latinoam Nutr. 2011;61:149–53.PubMed
6.
Blond JP, Henchiri C, Bezard J. Delta 6 and delta 5 desaturase activities in liver from obese Zucker rats at different ages. Lipids. 1989;24:389–95.CrossRefPubMed
7.
Rodriguez Y, Giri M, Rottiers R, et al. Obese type 2 diabetics and obese patients have comparable plasma phospholipid fatty acid compositions deviating from that of healthy individuals. Prostaglandins Leukot Essent Fat Acids. 2004;71:303–8.CrossRef
8.
Steffen BT, Steffen LM, Tracy R, et al. Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. Int J Obes. 2012;36:797–804.CrossRef
9.
Mueller-Cunningham WM, Quintana R, Kasim-Karakas SE. An ad libitum, very low-fat diet results in weight loss and changes in nutrient intakes in postmenopausal women. J Am Diet Assoc. 2003;103:1600–6.CrossRefPubMed
10.
Noakes M, Clifton PM. Changes in plasma lipids and other cardiovascular risk factors during 3 energy-restricted diets differing in total fat and fatty acid composition. Am J Clin Nutr. 2000;71:706–12.PubMed
11.
USDA/HHS. Dietary guidelines for Americans, 2010. U.S. Government Printing Office. Washington, DC: 2010.
12.
Tang AB, Nishimura KY, Phinney SD. Preferential reduction in adipose tissue a-linolenic acid (18:3w3) during very low calorie dieting despite supplementation with 18:3w3. Lipids. 1993;28:987–93.CrossRefPubMed
13.
Cunnane SC, Ross R, Bannister JL, et al. β-oxidation of linoleate in obese men undergoing weight loss. Am J Clin Nutr. 2001;73:709–14.PubMed
14.
Phinney SD, Davis PG, Johnson SB, et al. Obesity and weight loss alter serum phospholipids in humans. Am J Clin Nutr. 1991;53:831–8.PubMed
15.
Holman RT, Adams CE, Nelson RA, et al. Patients with anorexia nervosa demonstrate deficiencies of selected fatty acid, compensatory changes in nonessential fatty acids and decreased fluidity of plasma lipids. J Nutr. 1995;125:901–7.PubMed
16.
Sweene I, Rosling A, Tengblad S, et al. Essential fatty acid status in teenage girls with eating disorders and weight loss. Acta Paediatr. 2011;100:762–7.CrossRef
17.
Christophe A, Vermeulen A. Effects of weight loss on the fatty acid composition of serum lipids in obese women. Ann Nutr Metab. 1992;36:336–42.CrossRefPubMed
18.
Adams TD, Stroup AM, Gress RE, et al. Cancer incidence and mortality after gastric bypass surgery. Obesity (Silver Spring). 2009;17:796–802.CrossRef
19.
Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366:1567–76.CrossRefPubMedPubMedCentral
20.
Sjostrom L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307:56–65.CrossRefPubMed
21.
Moize V, Andreu A, Rodriguez L, et al. Protein intake and lean tissue mass retention following bariatric surgery. Clin Nutr. 2013;32:550–5.CrossRefPubMed
22.
Carlin AM, Rao DS, Yager KM, et al. Effect of gastric bypass surgery on vitamin D nutritional status. Surg Obes Relat Dis. 2006;2:638–42.CrossRefPubMed
23.
Ruz M, Carrasco F, Rojas P, et al. Iron absorption and iron status are reduced after Roux-en-Y gastric bypass. Am J Nutr. 2009;90:527–32.CrossRef
24.
25.
Halawi A, Abiad F, Abbas O. Bariatric surgery and its effects on the skin and skin diseases. Obes Surg. 2013;23:408–13.CrossRefPubMed
26.
Coupaye M, Puchaux K, Bogard C, et al. Nutritional consequences of adjustable gastric banding and gastric bypass: a 1-year prospective study. Obes Surg. 2009;19:56–65.CrossRefPubMed
27.
Elizondo A, Araya J, Rodrigo R, et al. Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease. Biol Res. 2008;41:59–68.CrossRefPubMed
28.
Kumar R, Lieske JC, Collazo-Clavell ML, et al. Fat malabsorption and increased oxalate absorption are common after Roux-en-Y gastric bypass surgery. Surgery. 2011;149:654–61.CrossRefPubMedPubMedCentral
29.
Odstrcil EA, Martinez JG, Santa Ana CA, et al. The contribution of malabsorption to the reduction in net energy absorption after long-limb Roux-en-Y gastric bypass. Am J Clin Nutr. 2010;92:704–13.CrossRefPubMed
30.
Gletsu-Miller N, Hansen JM, Jones DP, et al. Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring). 2009;17:439–46.CrossRef
31.
Lin E, Phillips LS, Ziegler TR, et al. Increases in adiponectin predict improved liver, but not peripheral, insulin sensitivity in severely obese women during weight loss. Diabetes. 2007;56:735–42.CrossRefPubMed
32.
33.
Lin E, Davis SS, Srinivasan J, et al. Dual mechanism for type-2 diabetes resolution after Roux-en-Y gastric bypass. Am Surg. 2009;75:498–502. discussion -3.PubMedPubMedCentral
34.
Anonymous. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2012;35 Suppl 1:S64–71.
35.
Gletsu-Miller N, Kahn HS, Gasevic D, Liang Z, Frediani JK, Torres WE, Ziegler TR, Phillips LS, Lin E. Sagittal abdominal diameter and visceral adiposity: correlates of beta-cell function and dysglycemia in severely obese women. Obes Surg. 2013.
36.
Liang Y, Roede JR, Dikalov S, et al. Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N, N'-diethyl-1,4-phenylenediamine oxidation. Clin Chim Acta. 2012;414:1–6.CrossRefPubMedPubMedCentral
37.
Ohta A, Mayo MC, Kramer N, et al. Rapid analysis of fatty acids in plasma lipids. Lipids. 1990;25:742–7.CrossRefPubMed
38.
Antalis CJ, Stevens LJ, Campbell M, et al. Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fat Acids. 2006;75:299–308.CrossRef
39.
Holman RT, Smythe L, Johnson S. Effect of sex and age on fatty acid composition of human serum lipids. Am J Clin Nutr. 1979;32:2390–9.PubMed
40.
Mechanick JI, Kushner RF, Sugerman HJ, et al. American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Obesity (Silver Spring). 2009;17 Suppl 1:S1–70.
41.
Garg ML, Thomson AB, Clandinin MT. Interactions of saturated, n-6 and n-3 polyunsaturated fatty acids to modulate arachidonic acid metabolism. J Lipid Res. 1990;31:271–7.PubMed
42.
Olbers T, Bjorkman S, Lindroos A, et al. Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial. Ann Surg. 2006;244:715–22.CrossRefPubMedPubMedCentral
43.
Carswell KA, Vincent RP, Belgaumkar AP, Sherwood RA, Amiel SA, Patel AG, le Roux CW. The effect of bariatric surgery on intestinal absorption and transit time. Obes Surg. 2013.
44.
Rossner S, Walldius G, Bjorvell H. Fatty acid composition in serum lipids and adipose tissue in severe obesity before and after six weeks of weight loss. Int J Obes. 1989;13:603–12.PubMed
45.
Kunesova M, Phinney S, Hainer V, et al. The responses of serum and adipose fatty acids to a one-year weight reduction regimen in female obese monozygotic twins. Ann N Y Acad Sci. 2002;967:311–23.CrossRefPubMed
46.
Tiikkainen M, Bergholm R, Rissanen A, et al. Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women. Am J Clin Nutr. 2004;79:22–30.PubMed
47.
Katz DP, Knittle JL. Effects of hypocaloric diet low in essential fatty acids on in vitro human adipose tissue prostaglandin production and essential fatty acid status. Nutrition. 1991;7:256–9.PubMed
48.
Kunesova M, Braunerova R, Hlavaty P, et al. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol Res. 2006;55:63–72.PubMed
49.
Hlavaty P, Kunesova M, Gojova M, et al. Change in fatty acid composition of serum lipids in obese females after short-term weight-reducing regimen with the addition of n-3 long chain polyunsaturated fatty acids in comparison to controls. Physiol Res. 2008;57 Suppl 1:S57–65.PubMed
50.
Haugaard SB, Vaag A, Hoy CE, et al. Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention. Obesity (Silver Spring). 2007;15:117–25.CrossRef
51.
Phinney SD, Tang AB, Johnson SB, et al. Reduced adipose 18:3w3 with weight loss by very low calorie dieting. Lipids. 1990;25:798–806.CrossRefPubMed
52.
Stamatikos AD, Paton CM. Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am J Physiol Endocrinol Metab. 2013;305:E767–75.CrossRefPubMed
53.
Demaria EJ, Winegar DA, Pate VW, et al. Early postoperative outcomes of metabolic surgery to treat diabetes from sites participating in the ASMBS bariatric surgery center of excellence program as reported in the Bariatric Outcomes Longitudinal Database. Ann Surg. 2010;252:559–66. discussion 66-7.PubMed
54.
Keidar A, Hershkop KJ, Marko L, et al. Roux-en-Y gastric bypass vs sleeve gastrectomy for obese patients with type 2 diabetes: a randomised trial. Diabetologia. 2013;56:1914–8.CrossRefPubMed
55.
Bradley D, Conte C, Mittendorfer B, et al. Gastric bypass and banding equally improve insulin sensitivity and beta cell function. J Clin Invest. 2012;122:4667–74.CrossRefPubMedPubMedCentral
56.
Ballantyne GH, Farkas D, Laker S, et al. Short-term changes in insulin resistance following weight loss surgery for morbid obesity: laparoscopic adjustable gastric banding versus laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2006;16:1189–97.CrossRefPubMed
57.
Poslusna K, Ruprich J, de Vries JH, et al. Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice. Br J Nutr. 2009;101 Suppl 2:S73–85.CrossRefPubMed
Metadata
Title
Essential Fatty Acid Plasma Profiles Following Gastric Bypass and Adjusted Gastric Banding Bariatric Surgeries
Authors
Rebekah Forbes
Danijela Gasevic
Emily M. Watson
Thomas R. Ziegler
Edward Lin
John R. Burgess
Nana Gletsu-Miller
Publication date
01-06-2016
Publisher
Springer US
Published in
Obesity Surgery / Issue 6/2016
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-015-1876-3

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