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Open Access 01-12-2021 | Esophagus Resection | Research article

Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

Authors: Chi Zhang, Xiao Kun Li, Li Wen Hu, Chao Zheng, Zhuang Zhuang Cong, Yang Xu, Jing Luo, Gao Ming Wang, Wen Feng Gu, Kai Xie, Chao Luo, Yi Shen

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Introduction

Among the many possible postoperative complications, anastomotic leakage (AL) is the most common and serious. Therefore, the purpose of this study was to explore the ability of various inflammatory and nutritional markers to predict postoperative AL in patients after esophagectomy.

Methods

A total of 273 patients were retrospectively evaluated and enrolled into this study. Perioperative, surgery-related, tumor-related and laboratory tests data were extracted and analyzed. The discriminatory ability and optimal cut-off value was evaluated according to the receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to access the potential risk factors for AL.

Results

The overall incidence of AL was 12.5% (34/273). C-reactive protein-to-albumin ratio (CRP/ALB ratio) [AUC 0.943 (95% confidence interval (CI) = 0.911–0.976, p < 0.001)] and operation time [AUC 0.747 (95% CI = 0.679–0.815, p < 0.001)] had the greatest discrimination on AL prediction. Multivariate analysis demonstrated that CRP/ALB ratio and operation time were two independent risk factors for AL, and CRP/ALB ratio (OR = 102.909, p < 0.001) had an advantage over operation time (OR = 9.363, p = 0.020; Table 3).

Conclusion

Operation time and postoperative CRP/ALB ratio were two independent predictive indexes for AL. Postoperative CRP/ALB ratio greater than 3.00 indicated a high risk of AL. For patients with abnormal postoperative CRP/ALB ratio, early non-operative treatment or surgical intervention are needed to reduce the serious sequelae of AL.

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Title: Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy
Authors: Chi Zhang
Xiao Kun Li
Li Wen Hu
Chao Zheng
Zhuang Zhuang Cong
Yang Xu
Jing Luo
Gao Ming Wang
Wen Feng Gu
Kai Xie
Chao Luo
Yi Shen
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Esophagus Resection
Esophagus Resection
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01515-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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