Skip to main content
Top
Published in: World Journal of Surgery 11/2019

01-11-2019 | Esophagus Resection | Original Scientific Report

International Variation in Surgical Practices in Units Performing Oesophagectomy for Oesophageal Cancer: A Unit Survey from the Oesophago-Gastric Anastomosis Audit (OGAA)

Author: Oesophago-Gastric Anastomosis Study Group on behalf of the West Midlands Research Collaborative

Published in: World Journal of Surgery | Issue 11/2019

Login to get access

Abstract

Background

Anastomotic leaks are associated with significant risk of morbidity, mortality and treatment costs after oesophagectomy. The aim of this study was to evaluate international variation in unit-level clinical practice and resource availability for the prevention and management of anastomotic leak following oesophagectomy.

Method

The Oesophago-Gastric Anastomosis Audit (OGAA) is an international research collaboration focussed on improving the care and outcomes of patients undergoing oesophagectomy. Any unit performing oesophagectomy worldwide can register to participate in OGAA studies. An online unit survey was developed and disseminated to lead surgeons at each unit registered to participate in OGAA. High-income country (HIC) and low/middle-income country (LMIC) were defined according to the World Bank whilst unit volume were defined as < 20 versus 20–59 versus ≥60 cases/year in the unit.

Results

Responses were received from 141 units, a 77% (141/182) response rate. Median annual oesophagectomy caseload was reported to be 26 (inter-quartile range 12–50). Only 48% (68/141) and 22% (31/141) of units had an Enhanced Recovery After Surgery (ERAS) program and ERAS nurse, respectively. HIC units had significantly higher rates of stapled anastomosis compared to LMIC units (66 vs 31%, p = 0.005). Routine post-operative contrast-swallow anastomotic assessment was performed in 52% (73/141) units. Stent placement and interventional radiology drainage for anastomotic leak management were more commonly available in HICs than LMICs (99 vs 59%, p < 0.001 and 99 vs 83%, p < 0.001).

Conclusions

This international survey highlighted variation in surgical technique and management of anastomotic leak based on case volume and country income level. Further research is needed to understand the impact of this variation on patient outcomes.
Appendix
Available only for authorised users
Literature
1.
go back to reference Collaborators GBDM (2018) Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1684–1735CrossRef Collaborators GBDM (2018) Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1684–1735CrossRef
2.
go back to reference Arnold M, Soerjomataram I, Ferlay J et al (2015) Global incidence of oesophageal cancer by histological subtype in 2012. Gut 64(3):381–387CrossRef Arnold M, Soerjomataram I, Ferlay J et al (2015) Global incidence of oesophageal cancer by histological subtype in 2012. Gut 64(3):381–387CrossRef
3.
go back to reference Blencowe NS, Strong S, McNair AG et al (2012) Reporting of short-term clinical outcomes after esophagectomy: a systematic review. Ann Surg 255(4):658–666CrossRef Blencowe NS, Strong S, McNair AG et al (2012) Reporting of short-term clinical outcomes after esophagectomy: a systematic review. Ann Surg 255(4):658–666CrossRef
4.
go back to reference Low DE, Alderson D, Cecconello I et al (2015) International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG). Ann Surg 262(2):286–294CrossRef Low DE, Alderson D, Cecconello I et al (2015) International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG). Ann Surg 262(2):286–294CrossRef
5.
go back to reference Busweiler LA, Henneman D, Dikken JL et al (2017) Failure-to-rescue in patients undergoing surgery for esophageal or gastric cancer. Eur J Surg Oncol 43(10):1962–1969CrossRef Busweiler LA, Henneman D, Dikken JL et al (2017) Failure-to-rescue in patients undergoing surgery for esophageal or gastric cancer. Eur J Surg Oncol 43(10):1962–1969CrossRef
6.
go back to reference Saeki H, Tsutsumi S, Tajiri H et al (2017) Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma. Ann Surg 265(3):527–533CrossRef Saeki H, Tsutsumi S, Tajiri H et al (2017) Prognostic significance of postoperative complications after curative resection for patients with esophageal squamous cell carcinoma. Ann Surg 265(3):527–533CrossRef
7.
go back to reference Molena D, Mungo B, Stem M et al (2014) Incidence and risk factors for respiratory complications in patients undergoing esophagectomy for malignancy: a NSQIP analysis. Semin Thorac Cardiovasc Surg 26(4):287–294CrossRef Molena D, Mungo B, Stem M et al (2014) Incidence and risk factors for respiratory complications in patients undergoing esophagectomy for malignancy: a NSQIP analysis. Semin Thorac Cardiovasc Surg 26(4):287–294CrossRef
8.
go back to reference Ferri LE, Law S, Wong KH et al (2006) The influence of technical complications on postoperative outcome and survival after esophagectomy. Ann Surg Oncol 13(4):557–564CrossRef Ferri LE, Law S, Wong KH et al (2006) The influence of technical complications on postoperative outcome and survival after esophagectomy. Ann Surg Oncol 13(4):557–564CrossRef
9.
go back to reference Low DE, Bodnar A (2013) Update on clinical impact, documentation, and management of complications associated with esophagectomy. Thorac Surg Clin 23(4):535–550CrossRef Low DE, Bodnar A (2013) Update on clinical impact, documentation, and management of complications associated with esophagectomy. Thorac Surg Clin 23(4):535–550CrossRef
10.
go back to reference National Institute for Health Research Global Health Research Unit on Global S (2019) Prioritizing research for patients requiring surgery in low- and middle-income countries. Br J Surg 106(2):e113–e120CrossRef National Institute for Health Research Global Health Research Unit on Global S (2019) Prioritizing research for patients requiring surgery in low- and middle-income countries. Br J Surg 106(2):e113–e120CrossRef
11.
go back to reference Xia BT, Rosato EL, Chojnacki KA et al (2013) Major perioperative morbidity does not affect long-term survival in patients undergoing esophagectomy for cancer of the esophagus or gastroesophageal junction. World J Surg 37(2):408–415CrossRef Xia BT, Rosato EL, Chojnacki KA et al (2013) Major perioperative morbidity does not affect long-term survival in patients undergoing esophagectomy for cancer of the esophagus or gastroesophageal junction. World J Surg 37(2):408–415CrossRef
12.
go back to reference Lagarde SM, de Boer JD, ten Kate FJ et al (2008) Postoperative complications after esophagectomy for adenocarcinoma of the esophagus are related to timing of death due to recurrence. Ann Surg 247(1):71–76CrossRef Lagarde SM, de Boer JD, ten Kate FJ et al (2008) Postoperative complications after esophagectomy for adenocarcinoma of the esophagus are related to timing of death due to recurrence. Ann Surg 247(1):71–76CrossRef
13.
go back to reference Findlay L, Yao C, Bennett DH et al (2017) Non-inferiority of minimally invasive oesophagectomy: an 8-year retrospective case series. Surg Endosc 31(9):3681–3689CrossRef Findlay L, Yao C, Bennett DH et al (2017) Non-inferiority of minimally invasive oesophagectomy: an 8-year retrospective case series. Surg Endosc 31(9):3681–3689CrossRef
14.
go back to reference Karl RC, Schreiber R, Boulware D et al (2000) Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg 231(5):635–643CrossRef Karl RC, Schreiber R, Boulware D et al (2000) Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg 231(5):635–643CrossRef
15.
go back to reference Low DE, Allum W, De Manzoni G et al (2019) Guidelines for perioperative care in esophagectomy: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg 43(2):299–330CrossRef Low DE, Allum W, De Manzoni G et al (2019) Guidelines for perioperative care in esophagectomy: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg 43(2):299–330CrossRef
17.
go back to reference Maynard NB (2016) I. AUGIS provision of Upper GI services document Maynard NB (2016) I. AUGIS provision of Upper GI services document
18.
go back to reference van Lanschot JJ, Hulscher JB, Buskens CJ et al (2001) Hospital volume and hospital mortality for esophagectomy. Cancer 91(8):1574–1578CrossRef van Lanschot JJ, Hulscher JB, Buskens CJ et al (2001) Hospital volume and hospital mortality for esophagectomy. Cancer 91(8):1574–1578CrossRef
19.
go back to reference Hsu PK, Chen HS, Wu SC et al (2014) Impact of hospital volume on long-term survival after resection for oesophageal cancer: a population-based study in Taiwandagger. Eur J Cardiothorac Surg 46(6):e127–e135 (discussion e135) CrossRef Hsu PK, Chen HS, Wu SC et al (2014) Impact of hospital volume on long-term survival after resection for oesophageal cancer: a population-based study in Taiwandagger. Eur J Cardiothorac Surg 46(6):e127–e135 (discussion e135) CrossRef
20.
go back to reference Henneman D, Dikken JL, Putter H et al (2014) Centralization of esophagectomy: how far should we go? Ann Surg Oncol 21(13):4068–4074CrossRef Henneman D, Dikken JL, Putter H et al (2014) Centralization of esophagectomy: how far should we go? Ann Surg Oncol 21(13):4068–4074CrossRef
22.
23.
go back to reference Hagens ERC, Anderegg MCJ, van Berge Henegouwen MI et al (2018) International survey on the management of anastomotic leakage after esophageal resection. Ann Thorac Surg 106(6):1702–1708CrossRef Hagens ERC, Anderegg MCJ, van Berge Henegouwen MI et al (2018) International survey on the management of anastomotic leakage after esophageal resection. Ann Thorac Surg 106(6):1702–1708CrossRef
24.
go back to reference Mamidanna R, Ni Z, Anderson O et al (2016) Surgeon volume and cancer esophagectomy, gastrectomy, and pancreatectomy: a population-based study in England. Ann Surg 263(4):727–732CrossRef Mamidanna R, Ni Z, Anderson O et al (2016) Surgeon volume and cancer esophagectomy, gastrectomy, and pancreatectomy: a population-based study in England. Ann Surg 263(4):727–732CrossRef
25.
go back to reference Haverkamp L, Seesing MF, Ruurda JP et al (2017) Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer. Dis Esophagus 30(1):1–7PubMed Haverkamp L, Seesing MF, Ruurda JP et al (2017) Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer. Dis Esophagus 30(1):1–7PubMed
26.
go back to reference Hu Z, Wang X, An X et al (2017) The diagnostic value of routine contrast esophagram in anastomotic leaks after esophagectomy. World J Surg 41(8):2062–2067CrossRef Hu Z, Wang X, An X et al (2017) The diagnostic value of routine contrast esophagram in anastomotic leaks after esophagectomy. World J Surg 41(8):2062–2067CrossRef
27.
go back to reference Jones CM, Heah R, Clarke B et al (2015) Should routine radiological assessment of anastomotic integrity be performed after oesophagectomy with cervical anastomosis? Best evidence topic (BET). Int J Surg 15:90–94CrossRef Jones CM, Heah R, Clarke B et al (2015) Should routine radiological assessment of anastomotic integrity be performed after oesophagectomy with cervical anastomosis? Best evidence topic (BET). Int J Surg 15:90–94CrossRef
28.
go back to reference Cherny NI, Sullivan R, Torode J et al (2017) ESMO International Consortium Study on the availability, out-of-pocket costs and accessibility of antineoplastic medicines in countries outside of Europe. Ann Oncol 28(11):2633–2647CrossRef Cherny NI, Sullivan R, Torode J et al (2017) ESMO International Consortium Study on the availability, out-of-pocket costs and accessibility of antineoplastic medicines in countries outside of Europe. Ann Oncol 28(11):2633–2647CrossRef
29.
go back to reference Kitagawa H, Namikawa T, Iwabu J et al (2018) Assessment of the blood supply using the indocyanine green fluorescence method and postoperative endoscopic evaluation of anastomosis of the gastric tube during esophagectomy. Surg Endosc 32(4):1749–1754CrossRef Kitagawa H, Namikawa T, Iwabu J et al (2018) Assessment of the blood supply using the indocyanine green fluorescence method and postoperative endoscopic evaluation of anastomosis of the gastric tube during esophagectomy. Surg Endosc 32(4):1749–1754CrossRef
30.
go back to reference Armstrong G, Croft J, Corrigan N et al (2018) IntAct: intra-operative fluorescence angiography to prevent anastomotic leak in rectal cancer surgery: a randomized controlled trial. Colorectal Dis 20(8):O226–O234CrossRef Armstrong G, Croft J, Corrigan N et al (2018) IntAct: intra-operative fluorescence angiography to prevent anastomotic leak in rectal cancer surgery: a randomized controlled trial. Colorectal Dis 20(8):O226–O234CrossRef
31.
go back to reference Gustafsson UO, Scott MJ, Schwenk W et al (2013) Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS((R))) Society recommendations. World J Surg 37(2):259–284CrossRef Gustafsson UO, Scott MJ, Schwenk W et al (2013) Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS((R))) Society recommendations. World J Surg 37(2):259–284CrossRef
32.
go back to reference Song W, Wang K, Zhang RJ et al (2016) The enhanced recovery after surgery (ERAS) program in liver surgery: a meta-analysis of randomized controlled trials. Springerplus 5:207CrossRef Song W, Wang K, Zhang RJ et al (2016) The enhanced recovery after surgery (ERAS) program in liver surgery: a meta-analysis of randomized controlled trials. Springerplus 5:207CrossRef
33.
go back to reference Van Haren RM, Mehran RJ, Mena GE et al (2018) Enhanced recovery decreases pulmonary and cardiac complications after thoracotomy for lung cancer. Ann Thorac Surg 106(1):272–279CrossRef Van Haren RM, Mehran RJ, Mena GE et al (2018) Enhanced recovery decreases pulmonary and cardiac complications after thoracotomy for lung cancer. Ann Thorac Surg 106(1):272–279CrossRef
34.
go back to reference Xiong J, Szatmary P, Huang W et al (2016) Enhanced recovery after surgery program in patients undergoing pancreaticoduodenectomy: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 95(18):e3497CrossRef Xiong J, Szatmary P, Huang W et al (2016) Enhanced recovery after surgery program in patients undergoing pancreaticoduodenectomy: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 95(18):e3497CrossRef
35.
go back to reference Zhang L, Zhong Y, Lin H et al (2016) Outcomes of laparoscopy combined with enhanced recovery pathway for reversal of Hartmann’s procedure. Indian J Surg 78(6):453–457CrossRef Zhang L, Zhong Y, Lin H et al (2016) Outcomes of laparoscopy combined with enhanced recovery pathway for reversal of Hartmann’s procedure. Indian J Surg 78(6):453–457CrossRef
36.
go back to reference Parise P, Ferrari C, Cossu A et al (2018) Enhanced recovery after surgery (ERAS) pathway in esophagectomy: is a reasonable prediction of hospital stay possible? Ann Surg 270:77–83CrossRef Parise P, Ferrari C, Cossu A et al (2018) Enhanced recovery after surgery (ERAS) pathway in esophagectomy: is a reasonable prediction of hospital stay possible? Ann Surg 270:77–83CrossRef
37.
go back to reference Varagunam M, Hardwick R, Riley S et al (2018) Changes in volume, clinical practice and outcome after reorganisation of oesophago-gastric cancer care in England: a longitudinal observational study. Eur J Surg Oncol 44(4):524–531CrossRef Varagunam M, Hardwick R, Riley S et al (2018) Changes in volume, clinical practice and outcome after reorganisation of oesophago-gastric cancer care in England: a longitudinal observational study. Eur J Surg Oncol 44(4):524–531CrossRef
Metadata
Title
International Variation in Surgical Practices in Units Performing Oesophagectomy for Oesophageal Cancer: A Unit Survey from the Oesophago-Gastric Anastomosis Audit (OGAA)
Author
Oesophago-Gastric Anastomosis Study Group on behalf of the West Midlands Research Collaborative
Publication date
01-11-2019
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 11/2019
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-019-05080-1

Other articles of this Issue 11/2019

World Journal of Surgery 11/2019 Go to the issue