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Journal of Cardiothoracic Surgery
Published in: Journal of Cardiothoracic Surgery 1/2019

Open Access 01-12-2019 | Esophagus Resection | Case report

Esophageal adenocarcinoma with leukemoid reaction: a case report

Authors: Ge Yu, Huaijun Ji, Chuizheng Meng, Yixuan Huang, Guogang Gao, Chuanping Liu, Shanlei Wang, Lei Zhang, Jin Ju

Published in: Journal of Cardiothoracic Surgery | Issue 1/2019

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Abstract

Background

Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases.

Case presentation

A 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates and a biopsy confirmed LR and excluded chronic myelogenous leukemia. Following radical esophagectomy for an adenocarcinoma the WBC counts successively decreased to 10,450/mm3 and 8670/mm3 within 1 week and 1 month, respectively.

Conclusion

We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we also present a review of literature and an investigation of the clinical features. To our knowledge, this is the first report of LR associated with esophageal adenocarcinoma.
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Metadata
Title
Esophageal adenocarcinoma with leukemoid reaction: a case report
Authors
Ge Yu
Huaijun Ji
Chuizheng Meng
Yixuan Huang
Guogang Gao
Chuanping Liu
Shanlei Wang
Lei Zhang
Jin Ju
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2019
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-019-0893-z

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