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Published in: BMC Gastroenterology 1/2020

Open Access 01-12-2020 | Esophagography | Research article

Three-tube method and covered metallic stent for the treatment of anastomotic leakage after esophagectomy

Authors: Yonghua Bi, Zhengyang Wu, Mengfei Yi, Xinwei Han, Jianzhuang Ren

Published in: BMC Gastroenterology | Issue 1/2020

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Abstract

Background

Anastomotic leakage is common and life-threatening complication after esophagectomy. The management of esophageal anastomotic leakage remains challenging. We aimed to determine the safety, feasibility and efficacy of three-tube method and covered metallic stent placement for the management of anastomotic leakage.

Methods

Twenty-six consecutive patients with anastomotic leakage were treated using three-tube method and covered metallic stent and the medical records were retrospectively assessed. All patients received placement of abscess drainage tube, jejunal feeding tube and gastrointestinal decompression tube as well as esophageal covered stent, followed by continue abscess drainage, nutritional support and anti-inflammatory treatment. Tubes and esophageal stents will be removed once anastomotic leakage heals.

Results

The procedure was technically successful in 23 patients (95.8%). A total of 31 covered stents were used. Esophageal stents and abscess drainage tubes were successfully removed from 14 patients. The median retention duration was 2.3 months and 2.6 months for stent and abscess drainage tubes, respectively. No perioperative death, esophageal rupture, massive hemorrhage, or other severe complications were observed during procedures. The abscess cavity had markedly decreased in 8 patients or disappeared in 16 cases. During follow-up, 8 patients died of cancer recurrence and 2 patients died of severe pulmonary infection. The 1-, 3-, 5-year survival rates were 60.1, 51.5 and 51.5%, respectively.

Conclusion

Three-tube method and covered metallic stent placement is safe, feasible and efficacious for treatment of anastomotic leakage after esophagectomy.
Literature
1.
go back to reference Safranek PM, Cubitt J, Booth MI, Dehn TC. Review of open and minimal access approaches to oesophagectomy for cancer. Br J Surg. 2010;97(12):1845–53.CrossRef Safranek PM, Cubitt J, Booth MI, Dehn TC. Review of open and minimal access approaches to oesophagectomy for cancer. Br J Surg. 2010;97(12):1845–53.CrossRef
2.
go back to reference Pennathur A, Luketich JD. Resection for esophageal cancer: strategies for optimal management. Ann Thorac Surg. 2008;85(2):S751–6.CrossRef Pennathur A, Luketich JD. Resection for esophageal cancer: strategies for optimal management. Ann Thorac Surg. 2008;85(2):S751–6.CrossRef
3.
go back to reference Junemann-Ramirez M, Awan MY, Khan ZM, Rahamim JS. Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg. 2005;27(1):3–7.CrossRef Junemann-Ramirez M, Awan MY, Khan ZM, Rahamim JS. Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg. 2005;27(1):3–7.CrossRef
4.
go back to reference Zheng YZ, Dai SQ, Shan HB, Gao XY, Zhang LJ, Cao X, et al. Managing esophageal fistulae by endoscopic transluminal drainage in esophageal cancer patients with superior mediastinal sepsis after esophagectomy. Chin J Cancer. 2013;32(8):469–73.PubMedPubMedCentral Zheng YZ, Dai SQ, Shan HB, Gao XY, Zhang LJ, Cao X, et al. Managing esophageal fistulae by endoscopic transluminal drainage in esophageal cancer patients with superior mediastinal sepsis after esophagectomy. Chin J Cancer. 2013;32(8):469–73.PubMedPubMedCentral
5.
go back to reference Blewett CJ, Miller JD, Young JE, Bennett WF, Urschel JD. Anastomotic leaks after esophagectomy for esophageal cancer: a comparison of thoracic and cervical anastomoses. Ann Thorac Cardiovasc Surg. 2001;7(2):75–8.PubMed Blewett CJ, Miller JD, Young JE, Bennett WF, Urschel JD. Anastomotic leaks after esophagectomy for esophageal cancer: a comparison of thoracic and cervical anastomoses. Ann Thorac Cardiovasc Surg. 2001;7(2):75–8.PubMed
6.
go back to reference Hofstetter W, Swisher SG, Correa AM, Hess K, Putnam JB Jr, Ajani JA, et al. Treatment outcomes of resected esophageal cancer. Ann Surg. 2002;236(3):376–84 discussion 84-5.CrossRef Hofstetter W, Swisher SG, Correa AM, Hess K, Putnam JB Jr, Ajani JA, et al. Treatment outcomes of resected esophageal cancer. Ann Surg. 2002;236(3):376–84 discussion 84-5.CrossRef
7.
go back to reference Urschel JD. Esophagogastrostomy anastomotic leaks complicating esophagectomy: a review. Am J Surg. 1995;169(6):634–40.CrossRef Urschel JD. Esophagogastrostomy anastomotic leaks complicating esophagectomy: a review. Am J Surg. 1995;169(6):634–40.CrossRef
8.
go back to reference Toussaint E, Eisendrath P, Kwan V, Dugardeyn S, Deviere J, Le Moine O. Endoscopic treatment of postoperative enterocutaneous fistulas after bariatric surgery with the use of a fistula plug: report of five cases. Endoscopy. 2009;41(6):560–3.CrossRef Toussaint E, Eisendrath P, Kwan V, Dugardeyn S, Deviere J, Le Moine O. Endoscopic treatment of postoperative enterocutaneous fistulas after bariatric surgery with the use of a fistula plug: report of five cases. Endoscopy. 2009;41(6):560–3.CrossRef
9.
go back to reference Leers JM, Vivaldi C, Schafer H, Bludau M, Brabender J, Lurje G, et al. Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent. Surg Endosc. 2009;23(10):2258–62.CrossRef Leers JM, Vivaldi C, Schafer H, Bludau M, Brabender J, Lurje G, et al. Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent. Surg Endosc. 2009;23(10):2258–62.CrossRef
10.
go back to reference Lippert E, Klebl FH, Schweller F, Ott C, Gelbmann CM, Scholmerich J, et al. Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract. Int J Colorectal Dis. 2011;26(3):303–11.CrossRef Lippert E, Klebl FH, Schweller F, Ott C, Gelbmann CM, Scholmerich J, et al. Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract. Int J Colorectal Dis. 2011;26(3):303–11.CrossRef
11.
go back to reference Lang H, Piso P, Stukenborg C, Raab R, Jahne J. Management and results of proximal anastomotic leaks in a series of 1114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol. 2000;26(2):168–71.CrossRef Lang H, Piso P, Stukenborg C, Raab R, Jahne J. Management and results of proximal anastomotic leaks in a series of 1114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol. 2000;26(2):168–71.CrossRef
12.
go back to reference Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Ann Thorac Surg. 2004;77(4):1475–83.CrossRef Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Ann Thorac Surg. 2004;77(4):1475–83.CrossRef
13.
go back to reference Fischer A, Thomusch O, Benz S, von Dobschuetz E, Baier P, Hopt UT. Nonoperative treatment of 15 benign esophageal perforations with self-expandable covered metal stents. Ann Thorac Surg. 2006;81(2):467–72.CrossRef Fischer A, Thomusch O, Benz S, von Dobschuetz E, Baier P, Hopt UT. Nonoperative treatment of 15 benign esophageal perforations with self-expandable covered metal stents. Ann Thorac Surg. 2006;81(2):467–72.CrossRef
14.
go back to reference Peters JH, Craanen ME, van der Peet DL, Cuesta MA, Mulder CJ. Self-expanding metal stents for the treatment of intrathoracic esophageal anastomotic leaks following esophagectomy. Am J Gastroenterol. 2006;101(6):1393–5.CrossRef Peters JH, Craanen ME, van der Peet DL, Cuesta MA, Mulder CJ. Self-expanding metal stents for the treatment of intrathoracic esophageal anastomotic leaks following esophagectomy. Am J Gastroenterol. 2006;101(6):1393–5.CrossRef
15.
go back to reference Freeman RK, Van Woerkom JM, Ascioti AJ. Esophageal stent placement for the treatment of iatrogenic intrathoracic esophageal perforation. Ann Thorac Surg. 2007;83(6):2003–7 discussion 7-8.CrossRef Freeman RK, Van Woerkom JM, Ascioti AJ. Esophageal stent placement for the treatment of iatrogenic intrathoracic esophageal perforation. Ann Thorac Surg. 2007;83(6):2003–7 discussion 7-8.CrossRef
16.
go back to reference Hunerbein M, Stroszczynski C, Moesta KT, Schlag PM. Treatment of thoracic anastomotic leaks after esophagectomy with self-expanding plastic stents. Ann Surg. 2004;240(5):801–7.CrossRef Hunerbein M, Stroszczynski C, Moesta KT, Schlag PM. Treatment of thoracic anastomotic leaks after esophagectomy with self-expanding plastic stents. Ann Surg. 2004;240(5):801–7.CrossRef
17.
go back to reference Kauer WK, Stein HJ, Dittler HJ, Siewert JR. Stent implantation as a treatment option in patients with thoracic anastomotic leaks after esophagectomy. Surg Endosc. 2008;22(1):50–3.CrossRef Kauer WK, Stein HJ, Dittler HJ, Siewert JR. Stent implantation as a treatment option in patients with thoracic anastomotic leaks after esophagectomy. Surg Endosc. 2008;22(1):50–3.CrossRef
18.
go back to reference Siersema PD. Treatment of esophageal perforations and anastomotic leaks: the endoscopist is stepping into the arena. Gastrointest Endosc. 2005;61(7):897–900.CrossRef Siersema PD. Treatment of esophageal perforations and anastomotic leaks: the endoscopist is stepping into the arena. Gastrointest Endosc. 2005;61(7):897–900.CrossRef
19.
go back to reference White RE, Mungatana C, Topazian M. Expandable stents for iatrogenic perforation of esophageal malignancies. J Gastrointest Surg. 2003;7(6):715–9 discussion 9-20.CrossRef White RE, Mungatana C, Topazian M. Expandable stents for iatrogenic perforation of esophageal malignancies. J Gastrointest Surg. 2003;7(6):715–9 discussion 9-20.CrossRef
20.
go back to reference Freeman RK, Ascioti AJ, Wozniak TC. Postoperative esophageal leak management with the Polyflex esophageal stent. J Thorac Cardiovasc Surg. 2007;133(2):333–8.CrossRef Freeman RK, Ascioti AJ, Wozniak TC. Postoperative esophageal leak management with the Polyflex esophageal stent. J Thorac Cardiovasc Surg. 2007;133(2):333–8.CrossRef
21.
go back to reference Schubert D, Scheidbach H, Kuhn R, Wex C, Weiss G, Eder F, et al. Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents. Gastrointest Endosc. 2005;61(7):891–6.CrossRef Schubert D, Scheidbach H, Kuhn R, Wex C, Weiss G, Eder F, et al. Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents. Gastrointest Endosc. 2005;61(7):891–6.CrossRef
22.
go back to reference Gelbmann CM, Ratiu NL, Rath HC, Rogler G, Lock G, Scholmerich J, et al. Use of self-expandable plastic stents for the treatment of esophageal perforations and symptomatic anastomotic leaks. Endoscopy. 2004;36(8):695–9.CrossRef Gelbmann CM, Ratiu NL, Rath HC, Rogler G, Lock G, Scholmerich J, et al. Use of self-expandable plastic stents for the treatment of esophageal perforations and symptomatic anastomotic leaks. Endoscopy. 2004;36(8):695–9.CrossRef
Metadata
Title
Three-tube method and covered metallic stent for the treatment of anastomotic leakage after esophagectomy
Authors
Yonghua Bi
Zhengyang Wu
Mengfei Yi
Xinwei Han
Jianzhuang Ren
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2020
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-020-01480-z

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