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01-05-2021 | Esophageal Cancer | Original Article

Clinical implications of the preoperative lymphocyte C-reactive protein ratio in esophageal cancer patients

Authors: Akira Yamamoto, Yuji Toiyama, Yoshinaga Okugawa, Takashi Ichikawa, Hiroki Imaoka, Hiromi Yasuda, Hiroyuki Fujikawa, Yoshiki Okita, Takeshi Yokoe, Masaki Ohi

Published in: Surgery Today | Issue 5/2021

Abstract

Purpose

We recently revealed the preoperative lymphocyte C-reactive protein ratio (LCR) to be a new marker for predicting various outcomes in malignancies. The aim of our present study was to clarify the potential utility of the preoperative LCR for predicting the perioperative risk and oncological outcome in esophageal cancer patients.

Methods

We analyzed the preoperative LCR from 153 esophageal cancer patients to clarify its clinical relevance.

Results

The preoperative LCR was significantly decreased in a stage-dependent manner, and a decreased preoperative LCR was significantly associated with the occurrence of postoperative surgical site infection. Esophageal cancer patients with a low LCR showed a poor outcome in both the overall survival and disease-free survival compared with those who had a high LCR. Multivariate analyses showed that a decreased LCR was an independent prognostic factor for both a poor overall survival and disease-free survival. A decreased preoperative LCR was an independent predictive factor for postoperative surgical site infection and significantly correlated with nutritional and inflammatory indicators. In addition, the LCR was useful for identifying esophageal cancer patients likely to have a poor outcome among patients with and without neoadjuvant chemotherapy.

Conclusions

Assessing the preoperative LCR might help physicians identify populations at high risk for perioperative complication and oncological outcomes, and determine individualized perioperative therapeutic strategies.

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Title: Clinical implications of the preoperative lymphocyte C-reactive protein ratio in esophageal cancer patients
Authors: Akira Yamamoto
Yuji Toiyama
Yoshinaga Okugawa
Takashi Ichikawa
Hiroki Imaoka
Hiromi Yasuda
Hiroyuki Fujikawa
Yoshiki Okita
Takeshi Yokoe
Masaki Ohi
Publication date: 01-05-2021
Publisher: Springer Singapore
Keywords: Esophageal Cancer
Esophageal Cancer
Published in: Surgery Today / Issue 5/2021
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-020-02166-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical implications of the preoperative lymphocyte C-reactive protein ratio in esophageal cancer patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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