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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2020

01-12-2020 | Esophageal Cancer | ASO Author Reflections

ASO Author Reflections: Prediction of the Therapeutic Efficacy in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma

Authors: Akihiko Okamura, MD, PhD, Satoru Matsuda, MD, PhD, Hirofumi Kawakubo, MD, PhD, Shinji Mine, MD, PhD, Hiroya Takeuchi, MD, PhD, Yuko Kitagawa, MD, PhD, Masayuki Watanabe, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2020

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Excerpt

Neoadjuvant therapy with chemotherapy or chemoradiotherapy has supplemented surgery as the standard treatment of locally advanced esophageal cancer. In Japan, the standard treatment for locally advanced resectable esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemotherapy (NAC) followed by esophagectomy. Although NAC is expected to improve curative resection rates and eliminate micrometastases, not a few patients experience a poor response to NAC or disease recurrence within the early postoperative period. …
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Shimada H, Nabeya Y, Okazumi S, et al. Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery. 2003;133:486–94.CrossRef
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Yokota T, Kato K, Hamamoto Y, et al. A 3–year overall survival update from a phase 2 study of chemoselection with DCF and subsequent conversion surgery for locally advanced unresectable esophageal cancer. Ann Surg Oncol. 2020;27:460–7.CrossRef
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Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019;393:1948–57.CrossRef
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Metadata
Title
ASO Author Reflections: Prediction of the Therapeutic Efficacy in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma
Authors
Akihiko Okamura, MD, PhD
Satoru Matsuda, MD, PhD
Hirofumi Kawakubo, MD, PhD
Shinji Mine, MD, PhD
Hiroya Takeuchi, MD, PhD
Yuko Kitagawa, MD, PhD
Masayuki Watanabe, MD, PhD
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08772-4

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