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Open Access 01-12-2021 | Erythromycin | Case report

Right-sided endocarditis caused by polyclonal Staphylococcus aureus infection

Authors: Yotam Kolben, Yuval Ishay, Henny Azmanov, Assaf Rokney, Moti Baum, Sharon Amit, Ran Nir-Paz

Published in: European Journal of Medical Research | Issue 1/2021

Abstract

We present a case of bacterial endocarditis with both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, which based on typing, originated from two distinct clones. Such a case may be misinterpreted by microbiology lab automation to be a monoclonal multi-drug resistant Staphylococcus aureus, while simple microbiology techniques will instantly reveal distinct clonality.

Campbell AJ, Al Yazidi LS, Phuong LK, et al. Pediatric Staphylococcus aureus bacteremia: clinical spectrum and predictors of poor outcome. Clin Infect Dis. 2021. https://doi.org/10.1093/cid/ciab510.CrossRefPubMed

Rose W, Fantl M, Geriak M, Nizet V, Sakoulas G. Current paradigms of combination therapy in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia: does it work, which combination and for which patients? Clin Infect Dis. 2021. https://doi.org/10.1093/cid/ciab452.CrossRefPubMed

Palraj BR, Baddour LM, Hess EP, et al. Predicting risk of endocarditis using a clinical tool (PREDICT): scoring system to guide use of echocardiography in the management of Staphylococcus aureus bacteremia. Clin Infect Dis. 2015;61(1):18–28. https://doi.org/10.1093/cid/civ235.CrossRefPubMedPubMedCentral

Fabijan AP, Ben Zakour NL, Ho J, Lin RCY, Iredell J, Corporation WBTTWaAB. Polyclonal Staphylococcus aureus bacteremia. Ann Intern Med. 2019;171(12):940–1. https://doi.org/10.7326/L19-0369.CrossRefPubMed

Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG. Infective endocarditis. Nat Rev Dis Primers. 2016;2:16059. https://doi.org/10.1038/nrdp.2016.59.CrossRefPubMedPubMedCentral

Pichon B, Hill R, Laurent F, et al. Development of a real-time quadruplex PCR assay for simultaneous detection of nuc, Panton-Valentine leucocidin (PVL), mecA and homologue mecALGA251. J Antimicrob Chemother. 2012;67(10):2338–41. https://doi.org/10.1093/jac/dks221.CrossRefPubMed

Fosheim GE, Nicholson AC, Albrecht VS, Limbago BM. Multiplex real-time PCR assay for detection of methicillin-resistant Staphylococcus aureus and associated toxin genes. J Clin Microbiol. 2011;49(8):3071–3. https://doi.org/10.1128/JCM.00795-11.CrossRefPubMedPubMedCentral

Killgore GE, Holloway B, Tenover FC. A 5′ nuclease PCR (TaqMan) high-throughput assay for detection of the mecA gene in staphylococci. J Clin Microbiol. 2000;38(7):2516–9. https://doi.org/10.1128/JCM.38.7.2516-2519.2000.CrossRefPubMedPubMedCentral

Boye K, Bartels MD, Andersen IS, Møller JA, Westh H. A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus SCCmec types I–V. Clin Microbiol Infect. 2007;13(7):725–7. https://doi.org/10.1111/j.1469-0691.2007.01720.x.CrossRefPubMed

10.

Berg AA. VI. A case of acute osteomyelitis of the femur, with general systemic Staphylococcus Aureus infection, terminating in recovery. Ann Surg. 1900;31(3):332–9. https://doi.org/10.1097/00000658-190001000-00030.CrossRefPubMedPubMedCentral

11.

van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL, Gosbell IB. Predictors of mortality in Staphylococcus aureus bacteremia. Clin Microbiol Rev. 2012;25(2):362–86. https://doi.org/10.1128/CMR.05022-11.CrossRefPubMedPubMedCentral

12.

Rao Q, Shang W, Hu X, Rao X. Staphylococcus aureus ST121: a globally disseminated hypervirulent clone. J Med Microbiol. 2015;64(12):1462–73. https://doi.org/10.1099/jmm.0.000185.CrossRefPubMed

13.

Uhlemann AC, Hafer C, Miko BA, et al. Emergence of sequence type 398 as a community- and healthcare-associated methicillin-susceptible Staphylococcus aureus in northern Manhattan. Clin Infect Dis. 2013;57(5):700–3. https://doi.org/10.1093/cid/cit375.CrossRefPubMedPubMedCentral

14.

Van Eldere J, Peetermans WE, Struelens M, Deplano A, Bobbaers H. Polyclonal staphylococcal endocarditis caused by genetic variability. Clin Infect Dis. 2000;31(1):24–30. https://doi.org/10.1086/313915.CrossRefPubMed

15.

Hakim A, Deplano A, Maes N, Kentos A, Rossi C, Struelens MJ. Polyclonal coagulase-negative staphylococcal catheter-related bacteremia documented by molecular identification and typing. Clin Microbiol Infect. 1999;5(4):224–7. https://doi.org/10.1111/j.1469-0691.1999.tb00128.x.CrossRefPubMed

16.

Huang YC, Su LH, Wu TL, Lin TY. Molecular surveillance of clinical methicillin-resistant Staphylococcus aureus isolates in neonatal intensive care units. Infect Control Hosp Epidemiol. 2005;26(2):157–60. https://doi.org/10.1086/502520.CrossRefPubMed

17.

Votintseva AA, Miller RR, Fung R, et al. Multiple-strain colonization in nasal carriers of Staphylococcus aureus. J Clin Microbiol. 2014;52(4):1192–200. https://doi.org/10.1128/JCM.03254-13.CrossRefPubMedPubMedCentral

18.

Cespedes C, Said-Salim B, Miller M, et al. The clonality of Staphylococcus aureus nasal carriage. J Infect Dis. 2005;191(3):444–52. https://doi.org/10.1086/427240.CrossRefPubMed

19.

Strahilevitz J, Zellermayer O, Vangel MG, Yonath H, Feinberg MS, Rubinstein E. Case clustering in infective endocarditis: the role of availability bias. Clin Microbiol Infect. 2005;11(12):955–7. https://doi.org/10.1111/j.1469-0691.2005.01255.x.CrossRefPubMed

Title: Right-sided endocarditis caused by polyclonal Staphylococcus aureus infection
Authors: Yotam Kolben
Yuval Ishay
Henny Azmanov
Assaf Rokney
Moti Baum
Sharon Amit
Ran Nir-Paz
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Erythromycin
Clindamycin
Endocarditis
Published in: European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-021-00549-z

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Right-sided endocarditis caused by polyclonal Staphylococcus aureus infection

Abstract

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Springer Medicine

Abstract

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