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Open Access 01-12-2017 | Erratum
Erratum to: Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
Published in: Journal of Hematology & Oncology | Issue 1/2017
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The original article [1] contained an error whereby the formatting of Table 1 was not presented correctly; this error has now been corrected.
Table 1
Clinical and molecular characteristics of TCGA AML patients according to the mutation and/or copy number variation status of genes encoding m6A regulatory enzymes
|
Mutation and/or CNV
|
CNV onlya
|
Mutation
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
Yes (n = 23)
|
No (n = 168)
|
P
|
Yes (n = 18)
|
No (n = 168)
|
P
|
Yes (n = 5)
|
No (n = 186)
|
P
|
|
|
Age
|
0.083
|
0.193
|
0.205
|
||||||
|
Median (range)
|
65 (18–81)
|
57 (21–88)
|
62.5 (18–81)
|
57 (21–88)
|
65 (45–76)
|
57.5 (18–88)
|
|||
|
Sex, no. (%)
|
0.123
|
0.321
|
0.376
|
||||||
|
Male
|
16 (8.4)
|
87 (45.5)
|
12 (6.5)
|
87 (46.8)
|
4 (2.1)
|
99 (51.8)
|
|||
|
Female
|
7 (3.7)
|
81 (42.4)
|
6 (3.2)
|
81 (43.5)
|
1 (0.5)
|
87 (45.5)
|
|||
|
BM blast
|
0.072
|
0.038
|
0.915
|
||||||
|
Median % (range)
|
60 (30–97)
|
73 (30–100)
|
54 (30–97)
|
73 (30–100)
|
75 (33–90)
|
72 (30–100)
|
|||
|
WBC, ×103/mm3
|
0.084
|
0.047
|
0.889
|
||||||
|
Median (range)
|
5.4 (0.7–202.7)
|
17.5 (0.4–298.4)
|
5.2 (2.3–101.3)
|
17.45 (0.4–298.4)
|
14.5 (2.3–101.3)
|
15.6 (0.4–298.4)
|
|||
|
Cytogenetic risk, no. (%)
|
<0.0001
|
<0.0001
|
0.483
|
||||||
|
Favorable
|
0 (0)
|
37 (19.4)
|
0 (0)
|
37 (19.9)
|
0 (0)
|
37 (19.4)
|
|||
|
Intermediate
|
4 (2.1)
|
105 (55)
|
1 (0.5)
|
105 (56.5)
|
3 (1.6)
|
106 (55.5)
|
|||
|
Unfavorable
|
19 (9.9)
|
21 (11)
|
17 (9.1)
|
21 (11.3)
|
2 (1)
|
38 (19.9)
|
|||
|
Missing data
|
0 (0)
|
5 (2.6)
|
0 (0)
|
5 (2.6)
|
0 (0)
|
5 (2.6)
|
|||
|
Mutation, no./total no. (%)
|
|||||||||
|
FLT3
|
1/23 (4.3)
|
53/168 (31.5)
|
0.005
|
0/18 (0)
|
53/168 (31.5)
|
0.002
|
1/5 (20)
|
53/186 (28.4)
|
1.000
|
|
NPM1
|
1/23 (4.3)
|
51/168 (30)
|
0.006
|
0/18 (0)
|
51/168 (30.3)
|
0.004
|
1/5 (20)
|
51/186 (27.4)
|
1.000
|
|
DNMT3A
|
4/23 (17.4)
|
43/168 (25.6)
|
0.453
|
2/18 (11.1)
|
43/168 (25.6)
|
0.249
|
2/5 (40)
|
45/186 (24.2)
|
0.598
|
|
IDH1 or IDH2
|
1/23 (4.3)
|
34/168 (20.2)
|
0.084
|
0/18 (0)
|
34/168 (20.2)
|
0.048
|
1/5 (20)
|
34/186 (18.3)
|
1.000
|
|
NRAS or KRAS
|
3/23 (13)
|
20/168 (11.9)
|
0.744
|
3/18 (16.7)
|
20/168 (11.9)
|
0.471
|
0/5 (0)
|
23/186 (12.4)
|
1.000
|
|
RUNX1
|
2/23 (8.7)
|
17/168 (10.1)
|
1.000
|
0/18 (0)
|
17/168 (10.1)
|
0.380
|
2/5 (40)
|
17/186 (9.1)
|
0.078
|
|
TET2
|
1/23 (4.3)
|
15/168 (8.9)
|
0.698
|
1/18(5.6)
|
15/168 (8.9)
|
1.000
|
0/5 (0)
|
16/186 (8.6)
|
1.000
|
|
TP53
|
15/23 (65.2)
|
1/168 (0.6)
|
<0.0001
|
13/18 (72.2)
|
1/168 (0.6)
|
<0.0001
|
2/5 (40)
|
14/186 (7.5)
|
0.057
|
|
CEBPA
|
2/23 (8.7)
|
10/168 (6.0)
|
0.641
|
2/18 (11.1)
|
10/168 (6.0)
|
0.327
|
0/5 (0)
|
12/186 (6.5)
|
1.000
|
|
WT1
|
0/23 (0)
|
12/168 (7.1)
|
0.366
|
0/18 (0)
|
12/168 (7.1)
|
0.610
|
0/5 (0)
|
12/186 (6.5)
|
1.000
|
|
PTPN11
|
2/23 (8.7)
|
6/168 (3.6)
|
0.248
|
2/18 (11.1)
|
6/168 (3.6)
|
0.175
|
0/5 (0)
|
8/186 (4.3)
|
1.000
|
|
KIT
|
1/23 (4.3)
|
6/168 (3.6)
|
0.599
|
0/18 (20)
|
6/168 (3.6)
|
1.000
|
1/5 (20)
|
6/186 (3.2)
|
0.172
|