01-04-2011 | Erratum
Erratum to: Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
Published in: Critical Care | Issue 2/2011
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After publication of our article [1] we noted that in Table 1 for Prothrombinex-VF 'Antithrombin and heparin added' should have been included under the 'Additional information' column. A copy of the table with the correct information can be found overleaf.
International units relative to factor IX
|
|||||||
---|---|---|---|---|---|---|---|
Brand name
|
Manufacturer
|
Factor II
|
Factor VII
|
Factor IX
|
Factor X
|
Viral inactivation
|
Additional information
|
Bebulin VH
|
Baxter BioScience, Austria
|
120
|
(13)
|
100
|
100
|
Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar
|
Heparin added
|
Beriplex P/N
|
CSL Behring, Germany
|
128
|
68
|
100
|
152
|
Pasteurisation at 60°C for 10 hours, and nanofiltration
|
Protein C; antithrombin, heparin and albumin added
|
Cofact
|
Sanquin, the Netherlands
|
56-140
|
28-80
|
100
|
56-140
|
Solvent/detergent and 15 nm nanofiltration
|
Antithrombin added
|
KASKADIL
|
LFB, France
|
148
|
40
|
100
|
160
|
Solvent/detergent
|
Heparin added
|
Octaplex
|
Octapharma, Austria and France
|
44-152
|
36-96
|
100
|
50
|
Solvent/detergent and nanofiltration
|
Heparin added; low activated factor VII content
|
Profilnine SD
|
Grifols, USA
|
148
|
(11)
|
100
|
64
|
Solvent/detergent
|
-
|
Prothrombinex VF
|
CSL Bioplasma, Australia
|
100
|
(-)
|
100
|
100
|
Dry heat, 80°C for 72 hours and nanofiltration
|
Antithrombin and heparin added
|
Prothromplex T
|
Baxter BioScience, Austria
|
100
|
85
|
100
|
100
|
Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar
|
Antithrombin and heparin added
|
UMAN Complex D.I.
|
Kedrion, Italy
|
100
|
(-)
|
100
|
80
|
Solvent/detergent and dry heat, 100°C for 30 minutes
|
Antithrombin and heparin added
|