Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
EJNMMI Research
Published in: EJNMMI Research 1/2016

Open Access 01-12-2016 | Erratum

Erratum to: Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

Authors: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs, Anne Roivainen

Published in: EJNMMI Research | Issue 1/2016

Login to get access

Excerpt

After publishing of the paper [1], substantial errors in Tables 4, 5, 6 and 7 have been noticed. The correct Tables 4, 5, 6 and 7 are presented here. Authors regret any inconvenience.
Table 4
Human residence times and radiation dose estimates for 68Ga radioactivity extrapolated from the rat biodistribution data
Organ
Residence time (h)
Dose (mSv/MBq)
 
Female rat data
Male rat data
Female rat data
Male rat data
Adrenals
   
0.01140
0.00931
Blood
0.2080
0.5000
   
Bone
0.6645
0.3089
   
Bone marrow
0.0907
0.0479
   
Brain
0.0348
0.0326
0.01800
0.01340
Breasts
   
0.00587
0.00615
Gallbladder wall
   
0.00955
0.00810
Heart wall
0.0208
0.0187
0.17400
0 30300
Kidneys
0.0196
0.0100
0.03850
0.01970
Liver
0.2526
0.2653
0.09720
0.07660
Lower large intestine wall
   
0.00319
0.00152
Lungs
0.3174
0.2770
0.18600
0.13400
Muscle
0.1014
0.1084
0.00729
0.00510
Osteogenic cells
   
0.11600
0.04310
Ovaries
0.0004
 
0.01880
0.00169
Pancreas
0.0019
0.0023
0.01870
0.01870
Red marrow
   
0.02250
0.01380
Skin
   
0.000292
0.00202
Small intestine
   
0.00388
0.00222
Spleen
   
0.00554
0.00412
Stomach wall
   
0.0565
0.00477
Testes
 
0.000028
 
0.00077
Thymus
   
0.01000
0.00139
Thyroid
0.0087
0.0095
0.22100
0.19800
Upper large intestine wall
   
0.00399
0.00268
Urinary bladder wall
   
0.00232
0.00106
Uterus
0.0137
 
0.007920
0.00142
Whole body
   
0.01770
0.01150
Effective dose
   
0.0483
0.0338
Table 5
Additional dosimetry estimates based on a female rat distribution data
 
Absorbed dose per unit radioactivity administered (mSv/MBq)
Organ
15-year-old (50 kg)
10-year-old (30 kg)
5-year-old (17 kg)
1-year-old (10 kg)
Newborn (5 kg)
Adrenals
0.01120
0.01640
0.02380
0.04030
0.07820
Brain
0.01590
0.01760
0.02060
0.02920
0.06670
Breasts
0.00581
0.01100
0.01630
0.02690
0.05450
Gallbladder wall
0.00920
0.01270
0.02010
0.03900
0.07500
Heart wall
0.19400
0.30100
0.48300
0.87300
1.72000
Kidneys
0.04210
0.06000
0.08880
0.16000
0.41500
Liver
0.09740
0.14800
0.22000
0.42700
0.98900
Lower large intestine wall
0.00321
0.00504
0.00771
0.01330
0.02920
Lungs
0.22400
0.31900
0.49300
0.98400
2.71000
Muscle
0.00757
0.01310
0.03190
0.06220
0.09540
Osteogenic cells
0.11400
0.18400
0.31000
0.73500
2.35000
Ovaries
0.02030
0.05660
0.09880
0.22500
0.45900
Pancreas
0.002180
0.04060
0.05470
0.11200
0.34000
Red marrow
0.02560
0.04150
0.07770
0.17700
0.57100
Skin
0.00281
0.00435
0.00671
0.01220
0.02710
Small intestine
0.00386
0.00619
0.00986
0.01780
0.03760
Spleen
0.00562
0.00858
0.01300
0.02380
0.04920
Stomach wall
0.00559
0.00800
0.01330
0.02500
0.05020
Thymus
0.01020
0.01330
0.01900
0.02970
0.05700
Thyroid
0.29800
0.46000
1.02000
1.93000
2.63000
Upper large intestine wall
0.00389
0.00669
0.01040
0.01900
0.04250
Urinary bladder wall
0.00223
0.00377
0.00625
0.01100
0.02220
Uterus
0.08020
1.34000
2.03000
3.69000
1.47000
Total body
0.01780
0.02890
0.04680
0.09200
0.23400
Effective dose (mSv/MBq)
0.05740
0.12300
0.20900
0.41000
0.71700
Table 6
Additional dosimetry estimates based on a male rat distribution data
 
Absorbed dose per unit radioactivity administered (mSv/MBq)
Organ
15-year-old (50 kg)
10-year-old (30 kg)
5-year-old (17 kg)
1-year-old (10 kg)
Newborn (5 kg)
Adrenals
0.01120
0.01650
0.02350
0.03770
0.07490
Brain
0.01370
0.01480
0.01700
0.02410
0.05630
Breasts
0.00743
0.01420
0.02130
0.03500
0.07250
Gallbladder wall
0.00960
0.01370
0.02130
0.04090
0.08030
Heart wall
0.39300
0.61100
0.98300
1.78000
3.4900
Kidneys
0.02410
0.03450
0.05100
0.09110
0.23100
Liver
0.10300
0.15700
0.23300
0.45000
1.04000
Lower large intestine wall
0.00197
0.00308
0.00506
0.00907
0.02040
Lungs
0.20000
0.28500
0.43900
0.87200
2.38000
Muscle
0.00739
0.01290
0.03260
0.06360
0.09610
Pancreas
0.02570
0.04800
0.06460
0.13100
0.40300
Red marrow
0.01540
0.02430
0.04410
0.09800
0.31100
Osteogenic cells
0.05580
0.09010
0.15100
0.35600
1.13000
Skin
0.00244
0.00362
0.00572
0.01030
0.02320
Small intestine
0.00287
0.00483
0.00796
0.01460
0.03090
Spleen
0.0327
0.0503
0.0801
0.1460
0.3780
Stomach wall
0.000657
0.00988
0.01530
0.02870
0.05600
Testes
0.00178
0.00745
0.00935
0.01380
0.02390
Thymus
0.01580
0.01940
0.02760
0.04170
0.07940
Thyroid
0.32500
0.50200
1.12000
2.1100
2.88000
Upper large intestine wall
0.00327
0.00581
0.00935
0.01820
0.03850
Urinary bladder wall
0.00129
0.00224
0.00393
0.00699
0.01520
Total body
0.01470
0.02370
0.03830
0.07480
0.19000
Effective dose (mSv/MBq)
0.05060
0.07560
0.13400
0.26000
0.55500
Table 7
Human effective doses of 68Ga radiopharmaceuticals and 18F-FDG
Radiopharmaceutical
Effective dose (mSv/MBq)
Reference
68Ga-DOTANOC
0.025
Pettinato 2008 [10]
68Ga-DOTATOC
0.023
Hartmann 2009 [11]
68Ga-DOTATATE
0.021
Sandström 2013 [12]
68Ga-NOTA-2Rs15d
0.0218a
Xavier 2013 [13]
BAY86-7548
0.051
Roivainen 2013 [14]
18F-FDG
0.0190
ICRP Publication 1998 [15]
68Ga-eluate
0.0483b, 0.0338c
Present study
aExtrapolated from tumour xenograft mice; bObtained by using female rat data; cObtained by using male rat data
…
Literature
1.
Autio A, Virtanen H, Tolvanen T, Liljenbäck H, Oikonen V, Saanijoki T, et al. Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry. EJNMMI Res. 2015;5(1):117. doi:10.​1186/​s13550-015-0117-z.
Metadata
Title
Erratum to: Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry
Authors
Anu Autio
Helena Virtanen
Tuula Tolvanen
Heidi Liljenbäck
Vesa Oikonen
Tiina Saanijoki
Riikka Siitonen
Meeri Käkelä
Andrea Schüssele
Mika Teräs
Anne Roivainen
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2016
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-016-0205-8

Other articles of this Issue 1/2016

EJNMMI Research 1/2016 Go to the issue

Original research

Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients

Short communication

Correlation of clinical outcomes with bremsstrahlung and Y-90 PET/CT imaging findings following Y-90 radiosynoviorthesis: a prospective study

Original research

177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Original research

Fractal and multifractal analysis of PET/CT images of metastatic melanoma before and after treatment with ipilimumab

Original research

Quantification of myocardial blood flow with 82Rb: Validation with 15O-water using time-of-flight and point-spread-function modeling

Original research

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11—first estimates for clinical translation