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Current Sexual Health Reports
Published in: Current Sexual Health Reports 4/2019

01-12-2019 | Erectile Dysfunction | Female Sexual Dysfunction and Disorders (A Pastuszak and N Thirumavalavan, Section Editors)

A Review of Genome Wide Association Studies for Erectile Dysfunction

Authors: Darshan P. Patel, Alexander W. Pastuszak, James M. Hotaling

Published in: Current Sexual Health Reports | Issue 4/2019

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Abstract

Purpose of Review

To review large cohort genome wide association studies for erectile dysfunction.

Recent Findings

Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucleotide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction.

Summary

Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction.
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Metadata
Title
A Review of Genome Wide Association Studies for Erectile Dysfunction
Authors
Darshan P. Patel
Alexander W. Pastuszak
James M. Hotaling
Publication date
01-12-2019
Publisher
Springer US
Published in
Current Sexual Health Reports / Issue 4/2019
Print ISSN: 1548-3584
Electronic ISSN: 1548-3592
DOI
https://doi.org/10.1007/s11930-019-00231-w

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