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Open Access 01-12-2021 | Epstein-Barr Virus | Research article

Prognostic value of noggin protein expression in patients with resected gastric cancer

Authors: Sang Hoon Chun, Eun Young Kim, Jung-Sook Yoon, Hye Sung Won, Kwangil Yim, Hye Won Hwang, Soon Auck Hong, Minho Lee, Su Lim Lee, Sung-Soo Kim, Der Sheng Sun, Yoon Ho Ko

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

Noggin and RNA-binding protein for multiple splicing 2 (RBPMS2) are known to regulate the expression of smooth muscle cells, endothelial cells, and osteoblasts. However, the prognostic role of combined Noggin and RBPMS2 expression in resected gastric cancer (GC) is unclear.

Methods

A total of 163 patients with GC who underwent gastrectomy were included in this study. The expression of Noggin and RBPMS2 proteins in tumor cells at the tumor center and invasive front of resected GC was evaluated by immunohistochemistry, and in conjunction with clinicopathological parameters the patient survival was analyzed.

Results

RBPMS2 protein expression was high at the tumor center (n = 86, 52.8%) and low at the invasive front (n = 69, 42.3%), while Noggin protein expression was high in both tumor center (n = 91, 55.8%) and the invasive front (n = 90, 55.2%). Noggin expression at the invasive front and tumor center was significantly decreased in advanced T stage, non-intestinal-type (invasive front, P = 0.008 and P < 0.001; tumor center lesion, P = 0.013 and P = 0.001). RBPMS2 expression at the invasive front was significantly decreased in non-intestinal-type and positive lymphatic invasion (P < 0.001 and P = 0.013). Multivariate analysis revealed that high Noggin protein expression of the invasive front was an independent prognostic factor for overall survival (hazard ratio [HR], 0.58; 95% confidence interval [CI]; 0.35–0.97, P < 0.036), but not at the tumor center (HR, 1.35; 95% CI; 0.81–2.26, P = 0.251).

Conclusions

Our study indicates that high Noggin expression is a crucial prognostic factor for favorable outcomes in patients with resected GC.

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Title: Prognostic value of noggin protein expression in patients with resected gastric cancer
Authors: Sang Hoon Chun
Eun Young Kim
Jung-Sook Yoon
Hye Sung Won
Kwangil Yim
Hye Won Hwang
Soon Auck Hong
Minho Lee
Su Lim Lee
Sung-Soo Kim
Der Sheng Sun
Yoon Ho Ko
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Epstein-Barr Virus
Gastric Cancer
Gastric Cancer
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08273-x

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