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Published in: Virchows Archiv 3/2021

01-03-2021 | Epstein-Barr Virus | Original Article

Clinicopathological analysis of neoplastic PD-L1-positive EBV+ diffuse large B cell lymphoma, not otherwise specified, in a Japanese cohort

Authors: Taishi Takahara, Akira Satou, Eri Ishikawa, Kei Kohno, Seiichi Kato, Yuka Suzuki, Emiko Takahashi, Akiko Ohashi, Naoko Asano, Toyonori Tsuzuki, Shigeo Nakamura

Published in: Virchows Archiv | Issue 3/2021

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Abstract

The programmed death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in the pathogenesis of Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS). Here, we describe PD-L1 expression by EBV+ DLBCL, NOS in order to evaluate its possible contribution to the pathogenesis of this tumor. The study included 57 cases of EBV+ DLBCL, NOS. The median patient age was 69 years and 95% (n = 54) were aged > 45. Extranodal lesions were present in 39 (69%) at initial diagnosis. PD-L1 expression (mAb SP142-positive staining) was present in more than 5% of tumor cells in only six cases (11%), in clear contrast to the 77% reported in cases aged under 45 years. Among the PD-L1+ cases, three were nodal lesions. All six PD-L1+ cases progressed in the 3 years after diagnosis and four of the six patients died of the disease within 2 years. PD-L1+ cases had significantly shorter PFS (P = 0.002) and relatively short OS (P = 0.26), compared with PD-L1− cases. EBV+ DLBCL, NOS in the elderly infrequently expressed PD-L1 and had poor prognosis. PD-L1 expression in EBV+ DLBCL, NOS of the elderly sheds light on the pathogenetic role of immune senescence.
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Metadata
Title
Clinicopathological analysis of neoplastic PD-L1-positive EBV+ diffuse large B cell lymphoma, not otherwise specified, in a Japanese cohort
Authors
Taishi Takahara
Akira Satou
Eri Ishikawa
Kei Kohno
Seiichi Kato
Yuka Suzuki
Emiko Takahashi
Akiko Ohashi
Naoko Asano
Toyonori Tsuzuki
Shigeo Nakamura
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv / Issue 3/2021
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-020-02901-w

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