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01-12-2009 | Case Report

Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature

Authors: Dimitris Zevgaridis, Christos Tsonidis, Nikiforos Kapranos, Ioannis Venizelos, Parmenion Tsitsopoulos, Philippos Tsitsopoulos

Published in: Acta Neurochirurgica | Issue 12/2009

Abstract

Introduction

A 45 year old female renal transplant recipient presented with headaches of 3 months duration. Clinical and radiological evaluation revealed an approximately 4x4cm rounded, enhancing mass at the left temporal pole. At surgery, the mass had dural attachment and clinically, radiographically, and macroscopically resembled a meningioma. Histopathological analysis revealed a leiomyoma. Epstein-Barr virus (EBV) DNA was demonstrated within the tumour cell nuclei by the in situ hybridisation technique.

Discussion

This is the first documentation of an EBV-associated primary intracranial leiomyoma in an organ transplant recipient and provides additional evidence of a possible relation between EBV infection and development of smooth-muscle tumours (SMT).

Conclusion

With increasing numbers of individuals being on long-term immuno-suppression, EBV-associated SMTs may be encountered more frequently in the future.

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Title: Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature
Authors: Dimitris Zevgaridis
Christos Tsonidis
Nikiforos Kapranos
Ioannis Venizelos
Parmenion Tsitsopoulos
Philippos Tsitsopoulos
Publication date: 01-12-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 12/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0307-4

At a glance: The STEP trials

Springer Medicine

Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature

Abstract

Introduction

Discussion

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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