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Molecular Cancer
Published in: Molecular Cancer 1/2013

Open Access 01-12-2013 | Review

Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

Authors: Timur R Samatov, Alexander G Tonevitsky, Udo Schumacher

Published in: Molecular Cancer | Issue 1/2013

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Abstract

Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.
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Metadata
Title
Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
Authors
Timur R Samatov
Alexander G Tonevitsky
Udo Schumacher
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2013
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-12-107

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