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European Radiology
Published in: European Radiology 12/2022

17-06-2022 | Epilepsy | Nuclear Medicine

Combined [18F]FDG-PET with MRI structural patterns in predicting post-surgical seizure outcomes in temporal lobe epilepsy patients

Authors: Zhen-Ming Wang, Peng-Hu Wei, Chunxiu Wang, Yaqin Hou, Kun Guo, Bixiao Cui, Yongzhi Shan, Guo-Guang Zhao, Jie Lu

Published in: European Radiology | Issue 12/2022

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Abstract

Objectives

To integrate the glucose metabolism measured using [18F]FDG PET/CT and anatomical features measured using MRI to forecast the post-surgical seizure outcomes of intractable temporal lobe epilepsy.

Methods

This retrospective study enrolled 63 patients with drug-resistant temporal lobe epilepsy. Z-transform of the patients’ PET images based on comparison with a database of healthy controls, cortical thickness, and quantitative anisotropy (QA) of the diffusion spectrum imaging concordant/non-concordant with cortical resection was adopted to quantify their predictive values for the post-surgical seizure outcomes.

Results

The PET hypometabolism region was concordant with the surgical field in 47 of the 63 patients. Forty-two patients were seizure-free post-surgery. The sensitivity and specificity of PET in predicting seizure freedom were 89.4% and 68.8%, respectively. Complete resection of foci with overlapped PET, cortical thickness, and QA abnormalities resulted in Engel I in 27 patients, which was a good predictor of seizure freedom with an odds ratio (OR) of 19.57 (95% CI 2.38–161.25, p = 0.006). Hypometabolism involved in multiple lobes (OR = 7.18, 95% CI 1.02–50.75, p = 0.048) and foci of hypometabolism with QA/cortical thickness abnormalities outside surgical field (OR = 14.72, 95% CI 2.13–101.56, p = 0.006) were two major predictors of Engel III/IV outcomes. ORs of QA to predict Engel I and seizure recurrence were 14.64 (95% CI 2.90–73.80, p = 0.001) and 12.01 (95% CI 2.91–49.65, p = 0.001), respectively.

Conclusion

Combined PET and structural pattern is helpful to predict the post-surgical seizure outcomes and worse outcomes of Engel III/IV. This might decrease unnecessary surgical injuries to patients who are potentially not amenable to surgery.

Key Points

• A combined metabolic and structural pattern is helpful to predict the post-surgical seizure outcomes.
• Favorable post-surgical seizure outcome was most likely reached in patients whose hypometabolism overlapped with the structural changes.
• Hypometabolism in multiple lobes and QA or cortical thickness abnormalities outside the surgical field were predictors of worse seizure outcomes of Engel III/IV.
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Metadata
Title
Combined [18F]FDG-PET with MRI structural patterns in predicting post-surgical seizure outcomes in temporal lobe epilepsy patients
Authors
Zhen-Ming Wang
Peng-Hu Wei
Chunxiu Wang
Yaqin Hou
Kun Guo
Bixiao Cui
Yongzhi Shan
Guo-Guang Zhao
Jie Lu
Publication date
17-06-2022
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 12/2022
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-022-08912-2

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