Top

Published in:

07-11-2023 | Epilepsy | Original Article

Use, experience and perspectives of high-density EEG among Italian epilepsy centers: a national survey

Authors: Bruna Nucera, Marco Perulli, Lara Alvisi, Francesca Bisulli, Paolo Bonanni, Laura Canafoglia, Gaetano Cantalupo, Edoardo Ferlazzo, Alice Granvillano, Oriano Mecarelli, Stefano Meletti, Gionata Strigaro, Elena Tartara, Giovanni Assenza

Published in: Neurological Sciences | Issue 4/2024

Abstract

Introduction

High-density EEG (hdEEG) is a validated tool in presurgical evaluation of people with epilepsy. The aim of this national survey is to estimate diffusion and knowledge of hdEEG to develop a network among Italian epilepsy centers.

Methods

A survey of 16 items (and 15 additional items) was distributed nationwide by email to all members of the Italian League Against Epilepsy and the Italian Society of Clinical Neurophysiology. The data obtained were analyzed using descriptive statistics.

Results

A total of 104 respondents were collected from 85 centers, 82% from the Centre-North of Italy; 27% of the respondents had a hdEEG. The main applications were for epileptogenic focus characterization in the pre-surgical evaluation (35%), biomarker research (35%) and scientific activity (30%). The greatest obstacles to hdEEG were economic resources (35%), acquisition of dedicated personnel (30%) and finding expertise (17%). Dissemination was limited by difficulties in finding expertise and dedicated personnel (74%) more than buying devices (9%); 43% of the respondents have already published hdEEG data, and 91% of centers were available to participate in multicenter hdEEG studies, helping in both pre-processing and analysis. Eighty-nine percent of respondents would be interested in referring patients to centers with established experience for clinical and research purposes.

Conclusions

In Italy, hdEEG is mainly used in third-level epilepsy centers for research and clinical purposes. HdEEG diffusion is limited not only by costs but also by lack of trained personnel. Italian centers demonstrated a high interest in educational initiatives on hdEEG as well as in clinical and research collaborations.

Sohrabpour A, Lu Y, Kankirawatana P, Blount J, Kim H, He B (2015) Effect of EEG electrode number on epileptic source localization in pediatric patients. Clin Neurophysiol 126(3):472–480. https://doi.org/10.1016/j.clinph.2014.05.038CrossRefPubMed

Brodbeck V, Spinelli L, Lascano AM et al (2011) Electroencephalographic source imaging: a prospective study of 152 operated epileptic patients. Brain 134(10):2887–2897. https://doi.org/10.1093/brain/awr243CrossRefPubMedPubMedCentral

Sharma P, Seeck M, Beniczky S (2019) Accuracy of interictal and ictal electric and magnetic source imaging: a systematic review and meta-analysis. Front Neurol 10:1250. https://doi.org/10.3389/FNEUR.2019.01250/BIBTEXCrossRefPubMedPubMedCentral

Li Y, Fogarty A, Razavi B, Ardestani PM, Falco-Walter J, Werbaneth K, Graber K, Meador K, Fisher RS (2022) Impact of high-density EEG in presurgical evaluation for refractory epilepsy patients. Clin Neurol Neurosurg 219:107336. https://doi.org/10.1016/j.clineuro.2022.107336CrossRefPubMed

Boon P, Carmichael DW, Mouthaan BE, et al. (2016) Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. Epilepsia. Published online 770-776 https://doi.org/10.1111/epi.13347

Stoyell SM, Wilmskoetter J, Dobrota MA, Chinappen DM, Bonilha L, Mintz M, Brinkmann BH, Herman ST, Peters JM, Vulliemoz S, Seeck M, Hämäläinen MS, Chu CJ (2021) High-density EEG in current clinical practice and opportunities for the future. J Clin Neurophysiol 38(2):112–123. https://doi.org/10.1097/WNP.0000000000000807CrossRefPubMedPubMedCentral

Kramer MA, Stoyell SM, Chinappen D et al (2021) Focal sleep spindle deficits reveal focal thalamocortical dysfunction and predict cognitive deficits in sleep activated developmental epilepsy. J Neurosci 41(8):1816–1829. https://doi.org/10.1523/JNEUROSCI.2009-20.2020CrossRefPubMedPubMedCentral

Strýček O, Lamoš M, Klimeš P, Rektor I (2020) Cognitive task-related functional connectivity alterations in temporal lobe epilepsy. Epilepsy Behav 112:107409. https://doi.org/10.1016/j.yebeh.2020.107409CrossRefPubMed

Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B (2021) Fast oscillations >40 Hz localize the epileptogenic zone: an electrical source imaging study using high-density electroencephalography. Clin Neurophysiol 132(2):568–580. https://doi.org/10.1016/j.clinph.2020.11.031CrossRefPubMed

10.

Bhatia S, Ham AT, Kutluay E (2022) High-density (HD) scalp EEG findings in “benign” childhood epilepsy with centrotemporal spikes (BCECTS). Clin EEG Neurosci 14:15500594221145264. https://doi.org/10.1177/15500594221145265CrossRef

11.

Duma GM, Danieli A, Mattar MG, Baggio M, Vettorel A, Bonanni P, Mento G (2022) Resting state network dynamic reconfiguration and neuropsychological functioning in temporal lobe epilepsy: an HD-EEG investigation. Cortex 157:1–13. https://doi.org/10.1016/j.cortex.2022.08.010CrossRefPubMed

12.

Vataman A, Ciolac D, Chiosa V, Aftene D, Leahu P, Winter Y, Groppa SA, Gonzalez-Escamilla G, Muthuraman M, Groppa S (2023) Dynamic flexibility and controllability of network communities in juvenile myoclonic epilepsy. Neurobiol Dis 25(179):106055. https://doi.org/10.1016/j.nbd.2023.106055CrossRef

13.

Coito A, Genetti M, Pittau F, Iannotti GR, Thomschewski A, Höller Y, Trinka E, Wiest R, Seeck M, Michel CM, Plomp G, Vulliemoz S (2016) Altered directed functional connectivity in temporal lobe epilepsy in the absence of interictal spikes: a high density EEG study. Epilepsia 57(3):402–411. https://doi.org/10.1111/epi.13308CrossRefPubMed

14.

Corona L, Tamilia E, Perry MS, Madsen JR, Bolton J, Stone SSD, Stufflebeam SM, Pearl PL, Papadelis C (2023) Non-invasive mapping of epileptogenic networks predicts surgical outcome. Brain 15:awac477. https://doi.org/10.1093/brain/awac477CrossRef

15.

Tamilia E, Matarrese MAG, Ntolkeras G, Grant PE, Madsen JR, Stufflebeam SM, Pearl PL, Papadelis C (2021) Noninvasive mapping of ripple onset predicts outcome in epilepsy surgery. Ann Neurol 89(5):911–925. https://doi.org/10.1002/ana.26066CrossRefPubMedPubMedCentral

16.

Sohrabpour A, He B (2021) Exploring the extent of source imaging: recent advances in noninvasive electromagnetic brain imaging. Curr Opin Biomed Eng 18 https://doi.org/10.1016/j.cobme.2021.100277

17.

van Mierlo P, Vorderwülbecke BJ, Staljanssens W, Seeck M, Vulliémoz S (2020) Ictal EEG source localization in focal epilepsy: review and future perspectives. Clin Neurophysiol 131(11):2600–2616. https://doi.org/10.1016/j.clinph.2020.08.001CrossRefPubMed

Title: Use, experience and perspectives of high-density EEG among Italian epilepsy centers: a national survey
Authors: Bruna Nucera
Marco Perulli
Lara Alvisi
Francesca Bisulli
Paolo Bonanni
Laura Canafoglia
Gaetano Cantalupo
Edoardo Ferlazzo
Alice Granvillano
Oriano Mecarelli
Stefano Meletti
Gionata Strigaro
Elena Tartara
Giovanni Assenza
Publication date: 07-11-2023
Publisher: Springer International Publishing
Keywords: Epilepsy
Expert Opinion
Expert Opinion
Published in: Neurological Sciences / Issue 4/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07159-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use, experience and perspectives of high-density EEG among Italian epilepsy centers: a national survey

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2024

Dural arteriovenous fistula presenting with recurrent focal status epilepticus and lateralised periodic epileptiform discharges

Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease

Impact of vortioxetine on psychosocial functioning moderated by symptoms of fatigue in post-COVID-19 condition: a secondary analysis

Effects of immediate thrombolytic treatment in imaging area on functional outcome in patients with acute ischemic stroke

Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy

Adult-onset leukoencephalopathy with persistent diffusion restriction dot lesions