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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2024 | Epilepsy | Review

Drug resistance predictive utility of age of onset and cortical imaging abnormalities in epilepsy: a systematic review and meta-analysis

Authors: Kehinde Alare, Bridget Ogungbemi, Ayomide Fagbenro, Busayo Adetunji, Oladoja Owonikoko, Taiwo Omoniyo, Habiblah Jagunmolu, Ayomide Kayode, Samson Afolabi

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2024

Abstract

Background

Drug resistance has been a global burden in the management of epilepsy. It is desirable if this could be predicted earlier in the course of management to give time for alternative and a more definitive mode of management, such as epilepsy surgeries.

Methods

We conducted a systematic review and meta-analysis to investigate the relationship between elevated age at the onset of the first seizure or cortical imaging abnormalities and the development of drug resistance in epilepsy. We performed a systematic search in PubMed, EMBASE, and SCOPUS databases for studies investigating the predictive utility of age of onset or cortical imaging abnormalities on drug resistance.

Results

Odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted and analyzed by the RevMan 5.4 software. Meta-analysis was done across 12 studies involving 5315 patients. Age of onset of seizures younger than 5 years was found to be associated with the development of drug resistance (OR: 0.685, 95% CI 0.410–0.960), also cortical imaging abnormalities were found to be associated with the development of drug resistance.

Conclusion

Children with early onset seizures could better from neurosurgical management than pharmacological management as the early age of onset was associated with drug resistance and cortical abnormalities on neuroimaging could be an indication for neurosurgical management of epilepsies.

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Title: Drug resistance predictive utility of age of onset and cortical imaging abnormalities in epilepsy: a systematic review and meta-analysis
Authors: Kehinde Alare
Bridget Ogungbemi
Ayomide Fagbenro
Busayo Adetunji
Oladoja Owonikoko
Taiwo Omoniyo
Habiblah Jagunmolu
Ayomide Kayode
Samson Afolabi
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keyword: Epilepsy
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2024
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-023-00786-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Drug resistance predictive utility of age of onset and cortical imaging abnormalities in epilepsy: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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