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24-04-2024 | Epilepsy | Editorial

Novel Mechanism, Drug Target and Therapy in Epilepsy

Authors: Cenglin Xu, Yi Wang, Zhong Chen

Published in: Neuroscience Bulletin

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Excerpt

Epilepsy, which is characterized by unprovoked seizures and has a prevalence of nearly 1%, is becoming one of the leading causes of disability and death globally [1]. The exact mechanisms behind epilepsy are still unknown, which contributes to the inadequate efficacy of anti-seizure medications (ASMs) that mainly target membrane ion channels and neurotransmission [2]. Crucially, a significant fraction of patients with epilepsy (PWE) will become tolerant to ASMs, termed pharmacoresistant epilepsy [3]. For the purpose of precisely managing epilepsy, it is important to comprehend the mechanisms underlying the condition to identify new therapeutic targets. This special issue, “Novel Mechanisms, Drug Target and Therapy in Epilepsy,” which includes two research articles, five reviews, and three research highlights, presents the latest advancements in epilepsy. …
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Metadata
Title
Novel Mechanism, Drug Target and Therapy in Epilepsy
Authors
Cenglin Xu
Yi Wang
Zhong Chen
Publication date
24-04-2024
Publisher
Springer Nature Singapore
Published in
Neuroscience Bulletin
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-024-01215-0