24-04-2024 | Epilepsy | Editorial
Novel Mechanism, Drug Target and Therapy in Epilepsy
Authors:
Cenglin Xu, Yi Wang, Zhong Chen
Published in:
Neuroscience Bulletin
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Excerpt
Epilepsy, which is characterized by unprovoked seizures and has a prevalence of nearly 1%, is becoming one of the leading causes of disability and death globally [
1]. The exact mechanisms behind epilepsy are still unknown, which contributes to the inadequate efficacy of anti-seizure medications (ASMs) that mainly target membrane ion channels and neurotransmission [
2]. Crucially, a significant fraction of patients with epilepsy (PWE) will become tolerant to ASMs, termed pharmacoresistant epilepsy [
3]. For the purpose of precisely managing epilepsy, it is important to comprehend the mechanisms underlying the condition to identify new therapeutic targets. This special issue, “Novel Mechanisms, Drug Target and Therapy in Epilepsy,” which includes two research articles, five reviews, and three research highlights, presents the latest advancements in epilepsy. …