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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 12/2023

07-07-2023 | Epilepsy in Children | Original Article

Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes

Authors: Gaoqiang Xu, Xiaoxi Chen, Yao Zhang

Published in: Japanese Journal of Radiology | Issue 12/2023

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Abstract

Purpose

The dysregulation of brain iron homeostasis is closely relevant to a multitude of chronic neurological disorders. This study employed quantitative susceptibility mapping (QSM) to detect and compare whole-brain iron content between childhood epilepsy with centrotemporal spikes (CECTS) children and typically developing children.

Materials and methods

32 children with CECTS and 25 age- and gender-matched healthy children were enrolled. All participants were imaged with 3.0-T MRI to acquire the structural and susceptibility-weighted data. The susceptibility-weighted data were processed using STISuite toolbox to obtain QSM. The magnetic susceptibility difference between the two groups was compared using voxel-wise and region of interest methods. Multivariable linear regression, controlling for age, were employed to investigate the associations between the brain magnetic susceptibility and age at onset.

Results

Lower magnetic susceptibility was mainly observed in sensory- and motor-related brain regions in children with CECTS, including bilateral middle frontal gyrus, supplementary motor area, midcingulate cortex, paracentral lobule and precentral gyrus, the magnetic susceptibility of right paracentral lobule, right precuneus and left supplementary motor area were found to have positive correlation with the age at onset.

Conclusions

This study suggests that the potential iron deficiency in certain brain regions is associated with CECTS, which might be helpful for further illumination of potential pathogenesis mechanism of CECTS.
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Metadata
Title
Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes
Authors
Gaoqiang Xu
Xiaoxi Chen
Yao Zhang
Publication date
07-07-2023
Publisher
Springer Nature Singapore
Published in
Japanese Journal of Radiology / Issue 12/2023
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-023-01464-5

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