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Environmental Health and Preventive Medicine

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Open Access 01-12-2021 | Epigenetics | Review article

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Authors: Reiko Kishi, Atsuko Ikeda-Araki, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Naomi Tamura, Machiko Minatoya, Rahel Mesfin Ketema, Kritika Poudel, Ryu Miura, Hideyuki Masuda, Mariko Itoh, Takeshi Yamaguchi, Hisanori Fukunaga, Kumiko Ito, Houman Goudarzi, the members of The Hokkaido Study on Environment and Children’s Health

Published in: Environmental Health and Preventive Medicine | Issue 1/2021

Abstract

Background

The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco.

Methods

The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures.

Results

The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies.

Conclusions

Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future.

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Title: Hokkaido birth cohort study on environment and children’s health: cohort profile 2021
Authors: Reiko Kishi
Atsuko Ikeda-Araki
Chihiro Miyashita
Sachiko Itoh
Sumitaka Kobayashi
Yu Ait Bamai
Keiko Yamazaki
Naomi Tamura
Machiko Minatoya
Rahel Mesfin Ketema
Kritika Poudel
Ryu Miura
Hideyuki Masuda
Mariko Itoh
Takeshi Yamaguchi
Hisanori Fukunaga
Kumiko Ito
Houman Goudarzi
the members of The Hokkaido Study on Environment and Children’s Health
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Epigenetics
Published in: Environmental Health and Preventive Medicine / Issue 1/2021
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-021-00980-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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