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Cancer Cell International
Published in: Cancer Cell International 1/2020

Open Access 01-12-2020 | Epigenetics | Primary research

DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups

Authors: Zijian Tian, Lingfeng Meng, Xingbo Long, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu, Jianye Wang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Background

Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics has been gained, providing new opportunities for cancer detection and treatment.

Methods

We identified prognostic methylation sites based on DNA methylation profiles of BCA in the TCGA database and constructed a specific prognostic subgroup.

Results

Based on the consistent clustering of 402 CpGs, we identified seven subgroups that had a significant association with survival. The difference in DNA methylation levels was related to T stage, N stage, M stage, grade, sex, age, stage and prognosis. Finally, the prediction model was constructed using a Cox regression model and verified using the test dataset; the prognosis was consistent with that of the training set.

Conclusions

The classification based on DNA methylation is closely related to the clinicopathological characteristics of BCA and determines the prognostic value of each epigenetic subtype. Therefore, our findings provide a basis for the development of DNA methylation subtype-specific therapeutic strategies for human bladder cancer.
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Metadata
Title
DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups
Authors
Zijian Tian
Lingfeng Meng
Xingbo Long
Tongxiang Diao
Maolin Hu
Miao Wang
Ming Liu
Jianye Wang
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Epigenetics
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01345-1

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