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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2009

01-07-2009 | Gastrointestinal Oncology

Epigenetics in Gastric Cancer: Challenges for Clinical Implications

Authors: D. Ziogas, MD, D. Roukos, MD

Published in: Annals of Surgical Oncology | Issue 7/2009

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Excerpt

Classic genetics alone cannot explain sporadic cancer and cancer development in patients with weak family history. The concept of epigenetics offers a partial explanation and may have important clinical implications for these types of cancer. The best-known epigenetic marker is DNA methylation, which occurs in CpG sites (islands), has critical roles in the control of gene activity, and is influenced by the modifications in histone structure that are commonly disrupted in cancer cells.1 …
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Metadata
Title
Epigenetics in Gastric Cancer: Challenges for Clinical Implications
Authors
D. Ziogas, MD
D. Roukos, MD
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 7/2009
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0472-y

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