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01-06-2007 | Review

Epidemiology of urinary bladder cancer: from tumor development to patient’s death

Authors: Cristiane Murta-Nascimento, Bernd J. Schmitz-Dräger, Maurice P. Zeegers, Gunnar Steineck, Manolis Kogevinas, Francisco X. Real, Núria Malats

Published in: World Journal of Urology | Issue 3/2007

Abstract

Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles identified from PubMed searches, reference lists, and book chapters dealing with the reviewed topics. Evaluation and consensus of both the contribution of each factor in bladder cancer burden and the appropriateness of the available evidences was done during an ad hoc meeting held during the 18th Congress of the European Society for Urological Research. Cigarette smoking and specific occupational exposures are the main known causes of UBC. Phenacetin, chlornaphazine and cyclophosphamide also increase the risk of bladder cancer. Chronic infection by Schistosoma haematobium is a cause of squamous cell carcinoma of the bladder. NAT2 slow acetylator and GSTM1 null genotypes are associated with an increased risk of this cancer. Vegetables and fresh fruits protect against this tumor. Regarding prognosis, there is little knowledge on the predictive role of environmental exposures and genetic polymorphisms on tumor recurrence and progression and patient’s death. Although active tobacco smoking is the most commonly studied factor, no definitive conclusion can be drawn from the literature. More research is needed regarding the effect of complex etiological factors in bladder carcinogenesis. Subgroup analysis according to stage, grade, and molecular features may help in identifying specific etiological and prognostic factors involved in different bladder cancer progression pathways.

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Title: Epidemiology of urinary bladder cancer: from tumor development to patient’s death
Authors: Cristiane Murta-Nascimento
Bernd J. Schmitz-Dräger
Maurice P. Zeegers
Gunnar Steineck
Manolis Kogevinas
Francisco X. Real
Núria Malats
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 3/2007
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-007-0168-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Epidemiology of urinary bladder cancer: from tumor development to patient’s death

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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