Skip to main content
Top
Published in: Pediatric Drugs 5/2009

01-10-2009 | Therapy In Practice

Epidemiology and Management of Essential Tremor in Children

Authors: Joseph Ferrara, Dr Joseph Jankovic

Published in: Pediatric Drugs | Issue 5/2009

Login to get access

Abstract

Essential tremor (ET) is a common, often familial, movement disorder characterized by tremor of the limbs, head, and voice. Epidemiological surveys indicate that up to 5% of the adult population has ET, and 5–30% of adults with ET report symptom onset during childhood. There is, however, little published regarding ET in the pediatric population, and no prospective studies targeted specifically to children. Retrospective studies from subspecialty movement disorder clinics indicate that childhood-onset ET is usually hereditary, begins at a mean age of 6 years, and affects boys three times as often as girls. While ET occasionally results in disability during childhood, only one-quarter of children seeing a neurologist for ET require pharmacotherapy. Small case series suggest that propranolol is effective in approximately 50% of children with ET, but controlled treatment trials are lacking.
Literature
1.
go back to reference Jankovic J. Tremors: diagnosis and management. In: Fahn S, Jankovic J, editors. Principles and practice of movement disorders. Philadelphia (PA): Churchill Livingston Elsevier, 2007: 451–78 Jankovic J. Tremors: diagnosis and management. In: Fahn S, Jankovic J, editors. Principles and practice of movement disorders. Philadelphia (PA): Churchill Livingston Elsevier, 2007: 451–78
2.
go back to reference FitzGerald PM, Jankovic J. Orthostatic tremor: an association with essential tremor. Mov Disord 1991; 6: 60–4PubMedCrossRef FitzGerald PM, Jankovic J. Orthostatic tremor: an association with essential tremor. Mov Disord 1991; 6: 60–4PubMedCrossRef
3.
go back to reference Gerschlager W, Munchau A, Katzenschlager R, et al. Natural history and syndromic associations of orthostatic tremor: a review of 41 patients. Mov Disord 2004; 19: 788–95PubMedCrossRef Gerschlager W, Munchau A, Katzenschlager R, et al. Natural history and syndromic associations of orthostatic tremor: a review of 41 patients. Mov Disord 2004; 19: 788–95PubMedCrossRef
4.
go back to reference Rosenbaum F, Jankovic J. Focal task-specific tremor and dystonia: categorization of occupational movement disorders. Neurology 1988; 38: 522–7PubMedCrossRef Rosenbaum F, Jankovic J. Focal task-specific tremor and dystonia: categorization of occupational movement disorders. Neurology 1988; 38: 522–7PubMedCrossRef
6.
go back to reference Davis CH, Kunkle EC. Benign essential (heredofamilial) tremor. Trans Am Neurol Assoc 1951; 56: 87–9PubMed Davis CH, Kunkle EC. Benign essential (heredofamilial) tremor. Trans Am Neurol Assoc 1951; 56: 87–9PubMed
7.
go back to reference Doshay LJ. Senile tremor versus Parkinson’s disease. Postgrad Med 1961; 30: 550–4PubMed Doshay LJ. Senile tremor versus Parkinson’s disease. Postgrad Med 1961; 30: 550–4PubMed
8.
go back to reference Louis ED, Broussolle E, Goetz CG, et al. Historical underpinnings of the term essential tremor in the late 19th century. Neurology 2008; 71: 856–9PubMedCrossRef Louis ED, Broussolle E, Goetz CG, et al. Historical underpinnings of the term essential tremor in the late 19th century. Neurology 2008; 71: 856–9PubMedCrossRef
9.
go back to reference Larsson T, Sjogren T. Essential tremor: a clinical and genetic population study. Acta Psychiatr Scand 1960; 36Suppl. 144: 1–176 Larsson T, Sjogren T. Essential tremor: a clinical and genetic population study. Acta Psychiatr Scand 1960; 36Suppl. 144: 1–176
10.
11.
go back to reference Lou JS, Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology 1991; 41: 234–8PubMedCrossRef Lou JS, Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology 1991; 41: 234–8PubMedCrossRef
12.
go back to reference Koller WC, Busenbark K, Miner K. The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group. Ann Neurol 1994; 35: 717–23PubMedCrossRef Koller WC, Busenbark K, Miner K. The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group. Ann Neurol 1994; 35: 717–23PubMedCrossRef
13.
go back to reference Paulson GW. Benign essential tremor in childhood: symptoms, pathogenesis, treatment. Clin Pediatr (Phila) 1976; 15: 67–70CrossRef Paulson GW. Benign essential tremor in childhood: symptoms, pathogenesis, treatment. Clin Pediatr (Phila) 1976; 15: 67–70CrossRef
14.
go back to reference Fernández-Alvarez E. Movement disorders with tremor as the main clinical manifestation. In: Fernandez-Alvarez E, Aicardi J. Movement disorders in children. London: Mac Keith Press, 2001: 43–62 Fernández-Alvarez E. Movement disorders with tremor as the main clinical manifestation. In: Fernandez-Alvarez E, Aicardi J. Movement disorders in children. London: Mac Keith Press, 2001: 43–62
15.
go back to reference Louis ED, Dure IV LS, Pullman S. Essential tremor in childhood: a series of nineteen cases. Mov Disord 2001; 16: 921–3PubMedCrossRef Louis ED, Dure IV LS, Pullman S. Essential tremor in childhood: a series of nineteen cases. Mov Disord 2001; 16: 921–3PubMedCrossRef
16.
go back to reference Louis ED, Fernandez-Alvarez E, Dure IV LS, et al. Association between male gender and pediatric essential tremor. Mov Disord 2005; 20: 904–6PubMedCrossRef Louis ED, Fernandez-Alvarez E, Dure IV LS, et al. Association between male gender and pediatric essential tremor. Mov Disord 2005; 20: 904–6PubMedCrossRef
17.
18.
go back to reference Tan EK, Lum SY, Prakash KM. Clinical features of childhood onset essential tremor. Eur J Neurol 2006; 13: 1302–5PubMedCrossRef Tan EK, Lum SY, Prakash KM. Clinical features of childhood onset essential tremor. Eur J Neurol 2006; 13: 1302–5PubMedCrossRef
19.
go back to reference Bain PG, Findley LJ, Thompson PD, et al. A study of hereditary essential tremor. Brain 1994; 117: 805–24PubMedCrossRef Bain PG, Findley LJ, Thompson PD, et al. A study of hereditary essential tremor. Brain 1994; 117: 805–24PubMedCrossRef
20.
go back to reference Elble RJ. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 2000; 54Suppl. 4: S2–6PubMed Elble RJ. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 2000; 54Suppl. 4: S2–6PubMed
21.
go back to reference Phibbs F, Fang JY, Cooper MK, et al. Prevalence of unilateral tremor in autosomal dominant essential tremor. Mov Disord 2009; 24: 108–11PubMedCrossRef Phibbs F, Fang JY, Cooper MK, et al. Prevalence of unilateral tremor in autosomal dominant essential tremor. Mov Disord 2009; 24: 108–11PubMedCrossRef
22.
go back to reference Whaley NR, Putzke JD, Baba Y, et al. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord 2007; 13: 333–9PubMedCrossRef Whaley NR, Putzke JD, Baba Y, et al. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord 2007; 13: 333–9PubMedCrossRef
23.
go back to reference Silverdale MA, Schneider SA, Bhatia KP, et al. The spectrum of orolingual tremor: a proposed classification system. Mov Disord 2008; 23: 159–67PubMedCrossRef Silverdale MA, Schneider SA, Bhatia KP, et al. The spectrum of orolingual tremor: a proposed classification system. Mov Disord 2008; 23: 159–67PubMedCrossRef
24.
go back to reference Louis ED, Ford B, Frucht S. Factors associated with increased risk of head tremor in essential tremor: a community-based study in northern Manhattan. Mov Disord 2003; 18: 432–6PubMedCrossRef Louis ED, Ford B, Frucht S. Factors associated with increased risk of head tremor in essential tremor: a community-based study in northern Manhattan. Mov Disord 2003; 18: 432–6PubMedCrossRef
25.
go back to reference Hardesty DE, Maraganore DM, Matsumoto JY, et al. Increased risk of head tremor in women with essential tremor: longitudinal data from the Rochester Epidemiology Project. Mov Disord 2004; 19: 529–33PubMedCrossRef Hardesty DE, Maraganore DM, Matsumoto JY, et al. Increased risk of head tremor in women with essential tremor: longitudinal data from the Rochester Epidemiology Project. Mov Disord 2004; 19: 529–33PubMedCrossRef
26.
go back to reference Fusco C, Valls-Solé J, Iturriaga C, et al. Electrophysiological approach to the study of essential tremor in children and adolescents. Dev Med Child Neurol 2003; 45: 624–7PubMedCrossRef Fusco C, Valls-Solé J, Iturriaga C, et al. Electrophysiological approach to the study of essential tremor in children and adolescents. Dev Med Child Neurol 2003; 45: 624–7PubMedCrossRef
27.
28.
go back to reference Jankovic J, Vuong KD, Thomas M. Psychogenic tremor: long-term outcome. CNS Spectrums 2006; 11: 501–8PubMed Jankovic J, Vuong KD, Thomas M. Psychogenic tremor: long-term outcome. CNS Spectrums 2006; 11: 501–8PubMed
29.
go back to reference Ferrara J, Jankovic J. Psychogenic movement disorders in children. Mov Disord 2008 Oct 15; 23: 1875–81PubMedCrossRef Ferrara J, Jankovic J. Psychogenic movement disorders in children. Mov Disord 2008 Oct 15; 23: 1875–81PubMedCrossRef
30.
31.
go back to reference Gasparini M, Bonifati V, Fabrizio E, et al. Frontal lobe dysfunction in essential tremor: a preliminary study. J Neurol 2001; 248: 399–402PubMedCrossRef Gasparini M, Bonifati V, Fabrizio E, et al. Frontal lobe dysfunction in essential tremor: a preliminary study. J Neurol 2001; 248: 399–402PubMedCrossRef
32.
go back to reference Troster AI, Woods SP, Fields JA, et al. Neuropsychological deficits in essential tremor: an expression of cerebello-thalamo-cortical pathophysiology? Eur J Neurol 2002; 9: 143–51PubMedCrossRef Troster AI, Woods SP, Fields JA, et al. Neuropsychological deficits in essential tremor: an expression of cerebello-thalamo-cortical pathophysiology? Eur J Neurol 2002; 9: 143–51PubMedCrossRef
33.
go back to reference Sahin HA, Terzi M, Uçak S, et al. Frontal functions in young patients with essential tremor: a case comparison study. J Neuropsychiatry Clin Neurosci 2006; 18: 64–72PubMedCrossRef Sahin HA, Terzi M, Uçak S, et al. Frontal functions in young patients with essential tremor: a case comparison study. J Neuropsychiatry Clin Neurosci 2006; 18: 64–72PubMedCrossRef
34.
go back to reference Benito-León J, Louis ED, Bermejo-Pareja F. Population-based case control study of cognitive function in essential tremor. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2006; 66: 69–74PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Population-based case control study of cognitive function in essential tremor. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2006; 66: 69–74PubMedCrossRef
35.
go back to reference Bermejo-Pareja F, Louis ED, Benito-León J. Risk of incident dementia in essential tremor: a population-based study. Neurological Disorders in Central Spain (NEDICES) Study Group. Mov Disord 2007; 22: 1573–80PubMedCrossRef Bermejo-Pareja F, Louis ED, Benito-León J. Risk of incident dementia in essential tremor: a population-based study. Neurological Disorders in Central Spain (NEDICES) Study Group. Mov Disord 2007; 22: 1573–80PubMedCrossRef
36.
go back to reference Ondo WG, Sutton L, Dat Vuong K, et al. Hearing impairment in essential tremor. Neurology 2003; 61: 1093–7PubMedCrossRef Ondo WG, Sutton L, Dat Vuong K, et al. Hearing impairment in essential tremor. Neurology 2003; 61: 1093–7PubMedCrossRef
37.
go back to reference Benito-León J, Louis ED, Bermejo-Pareja F. Reported hearing impairment in essential tremor: a population-based case-control study. Neurological Disorders in Central Spain (NEDICES) Study Group. Neuroepidemiology 2007; 29: 213–7PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Reported hearing impairment in essential tremor: a population-based case-control study. Neurological Disorders in Central Spain (NEDICES) Study Group. Neuroepidemiology 2007; 29: 213–7PubMedCrossRef
38.
go back to reference Singer C, Sanchez-Ramos J, Weiner WJ. Gait abnormality in essential tremor. Mov Disord 1994; 9: 193–6PubMedCrossRef Singer C, Sanchez-Ramos J, Weiner WJ. Gait abnormality in essential tremor. Mov Disord 1994; 9: 193–6PubMedCrossRef
39.
go back to reference Stolze H, Petersen G, Raethjen J, et al. The gait disorder of advanced essential tremor. Brain 2001; 124: 2278–86PubMedCrossRef Stolze H, Petersen G, Raethjen J, et al. The gait disorder of advanced essential tremor. Brain 2001; 124: 2278–86PubMedCrossRef
40.
go back to reference Bove M, Marinelli L, Avanzino L, et al. Posturographic analysis of balance control in patients with essential tremor. Mov Disord 2006; 2: 192–8CrossRef Bove M, Marinelli L, Avanzino L, et al. Posturographic analysis of balance control in patients with essential tremor. Mov Disord 2006; 2: 192–8CrossRef
41.
go back to reference Louis ED, Bromley SM, Jurewicz EC, et al. Olfactory dysfunction in essential tremor: a deficit unrelated to disease duration or severity. Neurology 2002; 59: 1631–3PubMedCrossRef Louis ED, Bromley SM, Jurewicz EC, et al. Olfactory dysfunction in essential tremor: a deficit unrelated to disease duration or severity. Neurology 2002; 59: 1631–3PubMedCrossRef
42.
go back to reference Louis ED, Jurewicz EC. Olfaction in essential tremor patients with and without isolated rest tremor. Mov Disord 2003; 18: 1387–9PubMedCrossRef Louis ED, Jurewicz EC. Olfaction in essential tremor patients with and without isolated rest tremor. Mov Disord 2003; 18: 1387–9PubMedCrossRef
43.
go back to reference Applegate LM, Louis ED. Essential tremor: mild olfactory dysfunction in a cerebellar disorder. Parkinsonism Relat Disord 2005; 11: 399–402PubMedCrossRef Applegate LM, Louis ED. Essential tremor: mild olfactory dysfunction in a cerebellar disorder. Parkinsonism Relat Disord 2005; 11: 399–402PubMedCrossRef
44.
go back to reference Helmchen C, Hagenow A, Miesner J, et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain 2003; 126: 1319–32PubMedCrossRef Helmchen C, Hagenow A, Miesner J, et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain 2003; 126: 1319–32PubMedCrossRef
45.
go back to reference Köster B, Deuschl G, Lauk M, et al. Essential tremor and cerebellar dysfunction: abnormal ballistic movements. J Neurol Neurosurg Psychiatry 2002; 73: 400–5PubMedCrossRef Köster B, Deuschl G, Lauk M, et al. Essential tremor and cerebellar dysfunction: abnormal ballistic movements. J Neurol Neurosurg Psychiatry 2002; 73: 400–5PubMedCrossRef
46.
go back to reference Trillenberg P, Fuhrer J, Sprenger A, et al. Eye-hand coordination in essential tremor. Mov Disord 2006; 21: 373–9PubMedCrossRef Trillenberg P, Fuhrer J, Sprenger A, et al. Eye-hand coordination in essential tremor. Mov Disord 2006; 21: 373–9PubMedCrossRef
47.
go back to reference Louis ED. Behavioral symptoms associated with essential tremor. Adv Neurol 2005; 96: 284–90PubMed Louis ED. Behavioral symptoms associated with essential tremor. Adv Neurol 2005; 96: 284–90PubMed
48.
go back to reference Lorenz D, Schwieger D, Moises H, et al. Quality of life and personality in essential tremor patients. Mov Disord 2006; 21: 1114–8PubMedCrossRef Lorenz D, Schwieger D, Moises H, et al. Quality of life and personality in essential tremor patients. Mov Disord 2006; 21: 1114–8PubMedCrossRef
49.
go back to reference Louis ED, Benito-León J, Bermejo-Pareja F. Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study. Neurological Disorders in Central Spain (NEDICES) Study Group. Eur J Neurol 2007; 14: 1138–46PubMedCrossRef Louis ED, Benito-León J, Bermejo-Pareja F. Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study. Neurological Disorders in Central Spain (NEDICES) Study Group. Eur J Neurol 2007; 14: 1138–46PubMedCrossRef
50.
go back to reference Schneier FR, Barnes LF, Albert SM, et al. Characteristics of social phobia among persons with essential tremor. J Clin Psychiatry 2001; 62: 367–72PubMedCrossRef Schneier FR, Barnes LF, Albert SM, et al. Characteristics of social phobia among persons with essential tremor. J Clin Psychiatry 2001; 62: 367–72PubMedCrossRef
51.
go back to reference Jankovic J. Essential tremor: clinical characteristics. Neurology 2000; 54Suppl. 4: S21–5PubMed Jankovic J. Essential tremor: clinical characteristics. Neurology 2000; 54Suppl. 4: S21–5PubMed
52.
go back to reference Ondo WG, Lai D. Association between restless legs syndrome and essential tremor. Mov Disord 2006; 21: 515–8PubMedCrossRef Ondo WG, Lai D. Association between restless legs syndrome and essential tremor. Mov Disord 2006; 21: 515–8PubMedCrossRef
53.
go back to reference Shahed J, Jankovic J. Exploring the relationship between essential tremor and Parkinson’s disease. Parkinsonism Relat Disord 2007; 13: 67–76PubMedCrossRef Shahed J, Jankovic J. Exploring the relationship between essential tremor and Parkinson’s disease. Parkinsonism Relat Disord 2007; 13: 67–76PubMedCrossRef
54.
go back to reference Benito-León J, Louis ED, Bermejo-Pareja F. Risk of incident Parkinson’s disease and parkinsonism in essential tremor: a population based study. Neurological Disorders in Central Spain (NEDICES) Study Group. J Neurol Neurosurg Psychiatry 2009; 80: 423–5PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Risk of incident Parkinson’s disease and parkinsonism in essential tremor: a population based study. Neurological Disorders in Central Spain (NEDICES) Study Group. J Neurol Neurosurg Psychiatry 2009; 80: 423–5PubMedCrossRef
55.
go back to reference Vanasse M, Bedard P, Andermann F. Shuddering attacks in children: an early clinical manifestation of essential tremor. Neurology 1976; 26: 1027–30PubMedCrossRef Vanasse M, Bedard P, Andermann F. Shuddering attacks in children: an early clinical manifestation of essential tremor. Neurology 1976; 26: 1027–30PubMedCrossRef
57.
58.
go back to reference Holmes GL, Russman BS. Shuddering attacks: evaluation using electroencephalographic frequency modulation radiotelemetry and videotape monitoring. Am J Dis Child 1986; 140: 72–3PubMed Holmes GL, Russman BS. Shuddering attacks: evaluation using electroencephalographic frequency modulation radiotelemetry and videotape monitoring. Am J Dis Child 1986; 140: 72–3PubMed
59.
go back to reference Reif-Lehrer L, Stemmermann MG. Monosodium glutamate intolerance in children [letter]. N Engl J Med 1975; 293: 1204–5PubMedCrossRef Reif-Lehrer L, Stemmermann MG. Monosodium glutamate intolerance in children [letter]. N Engl J Med 1975; 293: 1204–5PubMedCrossRef
60.
61.
go back to reference Münchau A, Schrag A, Chuang C, et al. Arm tremor in cervical dystonia differs from essential tremor and can be classified by onset age and spread of symptoms. Brain 2001; 124: 1765–76PubMedCrossRef Münchau A, Schrag A, Chuang C, et al. Arm tremor in cervical dystonia differs from essential tremor and can be classified by onset age and spread of symptoms. Brain 2001; 124: 1765–76PubMedCrossRef
62.
go back to reference Shaikh AG, Jinnah HA, Tripp RM, et al. Irregularity distinguishes limb tremor in cervical dystonia from essential tremor. J Neurol Neurosurg Psychiatry. 2008; 79: 187–9PubMedCrossRef Shaikh AG, Jinnah HA, Tripp RM, et al. Irregularity distinguishes limb tremor in cervical dystonia from essential tremor. J Neurol Neurosurg Psychiatry. 2008; 79: 187–9PubMedCrossRef
63.
go back to reference Louis ED, Ford B, Pullman S, et al. How normal is ‘normal’? Mild tremor in a multiethnic cohort of normal subjects. Arch Neurol 1998; 55: 222–7PubMedCrossRef Louis ED, Ford B, Pullman S, et al. How normal is ‘normal’? Mild tremor in a multiethnic cohort of normal subjects. Arch Neurol 1998; 55: 222–7PubMedCrossRef
64.
go back to reference Wenning GK, Kiechl S, Seppi K, et al. Prevalence of movement disorders in men and women aged 50–89 years (Bruneck Study cohort): a population-based study. Lancet Neurol 2005; 4: 815–20PubMedCrossRef Wenning GK, Kiechl S, Seppi K, et al. Prevalence of movement disorders in men and women aged 50–89 years (Bruneck Study cohort): a population-based study. Lancet Neurol 2005; 4: 815–20PubMedCrossRef
65.
go back to reference Robertson MM. Diagnosing Tourette syndrome: is it a common disorder? J Psychosom Res 2003; 55: 3–6PubMedCrossRef Robertson MM. Diagnosing Tourette syndrome: is it a common disorder? J Psychosom Res 2003; 55: 3–6PubMedCrossRef
66.
go back to reference Rautakorpi I, Takala J, Marttila RJ, et al. Essential tremor in a Finnish population. Acta Neurol Scand 1982; 66: 58–67PubMedCrossRef Rautakorpi I, Takala J, Marttila RJ, et al. Essential tremor in a Finnish population. Acta Neurol Scand 1982; 66: 58–67PubMedCrossRef
67.
go back to reference Louis ED, Ford B, Wendt KJ, et al. Clinical characteristics of essential tremor: data from a community-based study. Mov Disord 1998; 13: 803–8PubMedCrossRef Louis ED, Ford B, Wendt KJ, et al. Clinical characteristics of essential tremor: data from a community-based study. Mov Disord 1998; 13: 803–8PubMedCrossRef
68.
go back to reference Benito-León J, Bermejo-Pareja F, Louis ED. Incidence of essential tremor in three elderly populations of central Spain. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2005; 64: 1721–5PubMedCrossRef Benito-León J, Bermejo-Pareja F, Louis ED. Incidence of essential tremor in three elderly populations of central Spain. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2005; 64: 1721–5PubMedCrossRef
69.
go back to reference Dogu O, Louis ED, Sevim S, et al. Clinical characteristics of essential tremor in Mersin, Turkey: a population-based door-to-door study. J Neurol 2005; 252: 570–4PubMedCrossRef Dogu O, Louis ED, Sevim S, et al. Clinical characteristics of essential tremor in Mersin, Turkey: a population-based door-to-door study. J Neurol 2005; 252: 570–4PubMedCrossRef
70.
go back to reference Osuntokun BO, Adeuja AO, Schoenberg BS, et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987; 75: 13–21PubMedCrossRef Osuntokun BO, Adeuja AO, Schoenberg BS, et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987; 75: 13–21PubMedCrossRef
71.
go back to reference Li SC, Schoenberg BS, Wang CC, et al. A prevalence survey of Parkinson’s disease and other movement disorders in the People’s Republic of China. Arch Neurol 1985; 42: 655–7PubMedCrossRef Li SC, Schoenberg BS, Wang CC, et al. A prevalence survey of Parkinson’s disease and other movement disorders in the People’s Republic of China. Arch Neurol 1985; 42: 655–7PubMedCrossRef
72.
go back to reference Haimanot RT, Abebe M, Mariam AG, et al. Community-based study of neurological disorders in Ethiopia: development of a screening instrument. Ethiop Med J 1990; 28: 123–37PubMed Haimanot RT, Abebe M, Mariam AG, et al. Community-based study of neurological disorders in Ethiopia: development of a screening instrument. Ethiop Med J 1990; 28: 123–37PubMed
73.
go back to reference Dotchin CL, Walker RW. The prevalence of essential tremor in rural northern Tanzania. J Neurol Neurosurg Psychiatry 2008; 79: 1107–9PubMedCrossRef Dotchin CL, Walker RW. The prevalence of essential tremor in rural northern Tanzania. J Neurol Neurosurg Psychiatry 2008; 79: 1107–9PubMedCrossRef
74.
go back to reference Chouza C, Ketzoian C, Caamaño JL, et al. Prevalence of Parkinson’s disease in a population of Uruguay: preliminary results. Adv Neurol 1996; 69: 13–7PubMed Chouza C, Ketzoian C, Caamaño JL, et al. Prevalence of Parkinson’s disease in a population of Uruguay: preliminary results. Adv Neurol 1996; 69: 13–7PubMed
75.
go back to reference Tan LC, Venketasubramanian N, Ramasamy V, et al. Prevalence of essential tremor in Singapore: a study on three races in an Asian country. Parkinsonism Relat Disord 2005; 11: 233–9PubMedCrossRef Tan LC, Venketasubramanian N, Ramasamy V, et al. Prevalence of essential tremor in Singapore: a study on three races in an Asian country. Parkinsonism Relat Disord 2005; 11: 233–9PubMedCrossRef
76.
go back to reference Haerer AF, Anderson DW, Schoenberg BS. Prevalence of essential tremor: results from the Copiah County study. Arch Neurol 1982; 39: 750–1PubMedCrossRef Haerer AF, Anderson DW, Schoenberg BS. Prevalence of essential tremor: results from the Copiah County study. Arch Neurol 1982; 39: 750–1PubMedCrossRef
77.
go back to reference Salemi G, Savettieri G, Rocca WA, et al. Prevalence of essential tremor: a door-to-door survey in Terrasini, Sicily. Sicilian Neuro-Epidemiologic Study Group. Neurology 1994 Jan; 44: 61–4PubMedCrossRef Salemi G, Savettieri G, Rocca WA, et al. Prevalence of essential tremor: a door-to-door survey in Terrasini, Sicily. Sicilian Neuro-Epidemiologic Study Group. Neurology 1994 Jan; 44: 61–4PubMedCrossRef
78.
go back to reference Acosta J, Calderon E, Obeso JA. Prevalence of Parkinson’s disease and essential tremor in a village of south Spain [abstract]. Neurology 1989; 39Suppl. 1: 181 Acosta J, Calderon E, Obeso JA. Prevalence of Parkinson’s disease and essential tremor in a village of south Spain [abstract]. Neurology 1989; 39Suppl. 1: 181
79.
go back to reference Glik A, Masarwa M, Abuful A, et al. Essential tremor might be less frequent than Parkinson’s disease in North Israel Arab villages. Mov Disord 2009; 24: 119–22PubMedCrossRef Glik A, Masarwa M, Abuful A, et al. Essential tremor might be less frequent than Parkinson’s disease in North Israel Arab villages. Mov Disord 2009; 24: 119–22PubMedCrossRef
80.
go back to reference Mancini ML, Stracci F, Tambasco N, et al. Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study. Mov Disord 2007; 22: 540–5PubMedCrossRef Mancini ML, Stracci F, Tambasco N, et al. Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study. Mov Disord 2007; 22: 540–5PubMedCrossRef
81.
go back to reference Bharucha NE, Bharucha EP, Bharucha AE, et al. Prevalence of essential tremor in the Parsi community of Bombay, India. Arch Neurol 1988; 45: 907–8PubMedCrossRef Bharucha NE, Bharucha EP, Bharucha AE, et al. Prevalence of essential tremor in the Parsi community of Bombay, India. Arch Neurol 1988; 45: 907–8PubMedCrossRef
82.
go back to reference Sur H, Ilhan S, Erdoğan H, et al. Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. Parkinsonism Relat Disord 2009; 15: 101–4PubMedCrossRef Sur H, Ilhan S, Erdoğan H, et al. Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. Parkinsonism Relat Disord 2009; 15: 101–4PubMedCrossRef
83.
go back to reference Louis ED, Marder K, Cote L, et al. Differences in the prevalence of essential tremor among elderly African-Americans, whites and Hispanics in northern Manhattan, NY. Arch Neurol 1995; 52: 1201–5PubMedCrossRef Louis ED, Marder K, Cote L, et al. Differences in the prevalence of essential tremor among elderly African-Americans, whites and Hispanics in northern Manhattan, NY. Arch Neurol 1995; 52: 1201–5PubMedCrossRef
84.
go back to reference Dogu O, Sevim S, Camdeviren H, et al. Prevalence of essential tremor: door-to-door neurologic exams in Mersin Province, Turkey. Neurology 2003; 61: 1804–6PubMedCrossRef Dogu O, Sevim S, Camdeviren H, et al. Prevalence of essential tremor: door-to-door neurologic exams in Mersin Province, Turkey. Neurology 2003; 61: 1804–6PubMedCrossRef
85.
go back to reference Benito-León J, Bermejo-Pareja F, Morales JM, et al. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 2003; 18: 389–94PubMedCrossRef Benito-León J, Bermejo-Pareja F, Morales JM, et al. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 2003; 18: 389–94PubMedCrossRef
86.
go back to reference Bergareche A, De La Puente E, López de Munain A, et al. Prevalence of Parkinson’s disease and other types of Parkinsonism: a door-to-door survey in Bidasoa, Spain. J Neurol 2004; 251: 340–5PubMedCrossRef Bergareche A, De La Puente E, López de Munain A, et al. Prevalence of Parkinson’s disease and other types of Parkinsonism: a door-to-door survey in Bidasoa, Spain. J Neurol 2004; 251: 340–5PubMedCrossRef
87.
go back to reference Louis ED, Thawani SP, Andrews HF. Prevalence of essential tremor in a multiethnic, community-based study in northern Manhattan, New York, NY. Neuroepidemiology 2009; 32: 208–14PubMedCrossRef Louis ED, Thawani SP, Andrews HF. Prevalence of essential tremor in a multiethnic, community-based study in northern Manhattan, New York, NY. Neuroepidemiology 2009; 32: 208–14PubMedCrossRef
88.
go back to reference Das SK, Biswas A, Roy J, et al. Prevalence of major neurological disorders among geriatric population in the metropolitan city of Kolkata. J Assoc Physicians India 2008; 56: 175–81PubMed Das SK, Biswas A, Roy J, et al. Prevalence of major neurological disorders among geriatric population in the metropolitan city of Kolkata. J Assoc Physicians India 2008; 56: 175–81PubMed
89.
go back to reference Moghal S, Rajput AH, D’Arcy C, et al. Prevalence of movement disorders in elderly community residents. Neuroepidemiology 1994; 13: 175–8PubMedCrossRef Moghal S, Rajput AH, D’Arcy C, et al. Prevalence of movement disorders in elderly community residents. Neuroepidemiology 1994; 13: 175–8PubMedCrossRef
90.
go back to reference Louis ED, Ford B, Lee H, et al. Diagnostic criteria for essential tremor: a population perspective. Arch Neurol 1998; 55: 823–8PubMedCrossRef Louis ED, Ford B, Lee H, et al. Diagnostic criteria for essential tremor: a population perspective. Arch Neurol 1998; 55: 823–8PubMedCrossRef
91.
go back to reference Louis ED, Ford B, Wendt KJ, et al. A comparison of different bedside tests for essential tremor. Mov Disord 1999; 14: 462–7PubMedCrossRef Louis ED, Ford B, Wendt KJ, et al. A comparison of different bedside tests for essential tremor. Mov Disord 1999; 14: 462–7PubMedCrossRef
92.
go back to reference Rajput AH, Offord KP, Beard CM, et al. Essential tremor in Rochester, Minnesota: a 45-year study. J Neurol Neurosurg Psychiatry 1984; 47: 466–70PubMedCrossRef Rajput AH, Offord KP, Beard CM, et al. Essential tremor in Rochester, Minnesota: a 45-year study. J Neurol Neurosurg Psychiatry 1984; 47: 466–70PubMedCrossRef
93.
go back to reference Gerstenbrand F, Klingler D, Pfeiffer B. Essential tremor: phenomenology and epidemiology [in German]. Nervenarzt 1982; 53: 46–53PubMed Gerstenbrand F, Klingler D, Pfeiffer B. Essential tremor: phenomenology and epidemiology [in German]. Nervenarzt 1982; 53: 46–53PubMed
94.
go back to reference Louis ED, Dogu O. Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study. Neuroepidemiology 2007; 29: 208–12PubMedCrossRef Louis ED, Dogu O. Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study. Neuroepidemiology 2007; 29: 208–12PubMedCrossRef
95.
go back to reference Louis ED, Ford B, Frucht S, et al. Risk of tremor and impairment from tremor in relatives of patients with essential tremor: a community-based family study. Ann Neurol 2001; 49: 761–9PubMedCrossRef Louis ED, Ford B, Frucht S, et al. Risk of tremor and impairment from tremor in relatives of patients with essential tremor: a community-based family study. Ann Neurol 2001; 49: 761–9PubMedCrossRef
96.
go back to reference Louis ED, Ottman R. Study of possible factors associated with age of onset in essential tremor. Mov Disord 2006; 21: 1980–6PubMedCrossRef Louis ED, Ottman R. Study of possible factors associated with age of onset in essential tremor. Mov Disord 2006; 21: 1980–6PubMedCrossRef
97.
go back to reference Louis ED, Fried LP, Fitzpatrick AL, et al. Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United States. Mov Disord 2003; 18: 1035–40PubMedCrossRef Louis ED, Fried LP, Fitzpatrick AL, et al. Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United States. Mov Disord 2003; 18: 1035–40PubMedCrossRef
98.
go back to reference Louis ED, Barnes LF, Ford B, et al. Ethnic differences in essential tremor. Arch Neurol 2000; 57: 723–7PubMedCrossRef Louis ED, Barnes LF, Ford B, et al. Ethnic differences in essential tremor. Arch Neurol 2000; 57: 723–7PubMedCrossRef
99.
go back to reference Bain P, Brin M, Deuschl G, et al. Criteria for the diagnosis of essential tremor. Neurology 2000; 54Suppl. 4: S7PubMed Bain P, Brin M, Deuschl G, et al. Criteria for the diagnosis of essential tremor. Neurology 2000; 54Suppl. 4: S7PubMed
100.
go back to reference Elble RJ. Characteristics of physiologic tremor in young and elderly adults. Clin Neurophysiol 2003; 114: 624–35PubMedCrossRef Elble RJ. Characteristics of physiologic tremor in young and elderly adults. Clin Neurophysiol 2003; 114: 624–35PubMedCrossRef
101.
go back to reference Ryan MM, Jones Jr HR. CMTX mimicking childhood chronic inflammatory demyelinating neuropathy with tremor. Muscle Nerve 2005; 31: 528–30PubMedCrossRef Ryan MM, Jones Jr HR. CMTX mimicking childhood chronic inflammatory demyelinating neuropathy with tremor. Muscle Nerve 2005; 31: 528–30PubMedCrossRef
102.
go back to reference Gottlob I, Zubcov A, Catalano RA, et al. Signs distinguishing spasmus nutans (with and without central nervous system lesions) from infantile nystagmus. Ophthalmology 1990; 97: 1166–75PubMed Gottlob I, Zubcov A, Catalano RA, et al. Signs distinguishing spasmus nutans (with and without central nervous system lesions) from infantile nystagmus. Ophthalmology 1990; 97: 1166–75PubMed
103.
go back to reference Hertle RW, Zhu X. Oculographic and clinical characterization of thirty-seven children with anomalous head postures, nystagmus, and strabismus: the basis of a clinical algorithm. J AAPOS 2000; 4: 25–32PubMedCrossRef Hertle RW, Zhu X. Oculographic and clinical characterization of thirty-seven children with anomalous head postures, nystagmus, and strabismus: the basis of a clinical algorithm. J AAPOS 2000; 4: 25–32PubMedCrossRef
104.
go back to reference Bhattacharyya KB, Senapati A, Basu S, et al. Bobble-head doll syndrome: some atypical features with a new lesion and review of the literature. Acta Neurol Scand 2003; 108: 216–20PubMedCrossRef Bhattacharyya KB, Senapati A, Basu S, et al. Bobble-head doll syndrome: some atypical features with a new lesion and review of the literature. Acta Neurol Scand 2003; 108: 216–20PubMedCrossRef
105.
go back to reference Bourdain F, Apartis E, Trocello JM, et al. Clinical analysis in familial cortical myoclonic tremor allows differential diagnosis with essential tremor. Mov Disord 2006; 21: 599–608PubMedCrossRef Bourdain F, Apartis E, Trocello JM, et al. Clinical analysis in familial cortical myoclonic tremor allows differential diagnosis with essential tremor. Mov Disord 2006; 21: 599–608PubMedCrossRef
106.
go back to reference Schomer DL. Focal status epilepticus and epilepsia partialis continua in adults and children. Epilepsia 1993; 34Suppl. 1: S29–36PubMedCrossRef Schomer DL. Focal status epilepticus and epilepsia partialis continua in adults and children. Epilepsia 1993; 34Suppl. 1: S29–36PubMedCrossRef
107.
108.
go back to reference Harlow TL, Gonzalez-Alegre P. High prevalence of reported tremor in Klinefelter syndrome. Parkinsonism Relat Disord 2009; 15: 393–5PubMedCrossRef Harlow TL, Gonzalez-Alegre P. High prevalence of reported tremor in Klinefelter syndrome. Parkinsonism Relat Disord 2009; 15: 393–5PubMedCrossRef
109.
go back to reference Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. American Association for Study of Liver Diseases (AASLD). Hepatology 2008; 47: 2089–111PubMedCrossRef Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. American Association for Study of Liver Diseases (AASLD). Hepatology 2008; 47: 2089–111PubMedCrossRef
110.
go back to reference Bernard G, Shevell M. The wobbly child: an approach to inherited ataxias. Semin Pediatr Neurol 2008; 15: 194–208PubMedCrossRef Bernard G, Shevell M. The wobbly child: an approach to inherited ataxias. Semin Pediatr Neurol 2008; 15: 194–208PubMedCrossRef
111.
112.
go back to reference Rodnitzky RL. Drug-induced movement disorders in children and adolescents. Expert Opin Drug Saf 2005; 4: 91–102PubMedCrossRef Rodnitzky RL. Drug-induced movement disorders in children and adolescents. Expert Opin Drug Saf 2005; 4: 91–102PubMedCrossRef
114.
go back to reference Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008; 79: 368–76PubMedCrossRef Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008; 79: 368–76PubMedCrossRef
115.
go back to reference Schneider SA, Bhatia KP, Hardy J. Complicated recessive dystonia parkinsonism syndromes. Mov Disord 2009; 24: 490–8PubMedCrossRef Schneider SA, Bhatia KP, Hardy J. Complicated recessive dystonia parkinsonism syndromes. Mov Disord 2009; 24: 490–8PubMedCrossRef
116.
go back to reference Periquet M, Latouche M, Lohmann E, et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism. Brain 2003; 126: 1271–8PubMedCrossRef Periquet M, Latouche M, Lohmann E, et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism. Brain 2003; 126: 1271–8PubMedCrossRef
117.
go back to reference Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22–p25. Mov Disord 1997; 12: 859–64PubMedCrossRef Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22–p25. Mov Disord 1997; 12: 859–64PubMedCrossRef
118.
go back to reference Louis ED, Ford B, Frucht S, et al. Mild tremor in relatives of patients with essential tremor: what does this tell us about the penetrance of the disease? Arch Neurol 2001; 58: 1584–9PubMedCrossRef Louis ED, Ford B, Frucht S, et al. Mild tremor in relatives of patients with essential tremor: what does this tell us about the penetrance of the disease? Arch Neurol 2001; 58: 1584–9PubMedCrossRef
120.
go back to reference Louis ED. Etiology of essential tremor: should we be searching for environmental causes? Mov Disord 2001; 16: 822–9PubMedCrossRef Louis ED. Etiology of essential tremor: should we be searching for environmental causes? Mov Disord 2001; 16: 822–9PubMedCrossRef
121.
go back to reference Busenbark K, Barnes P, Lyons K, et al. Accuracy of reported family histories of essential tremor. Neurology 1996; 47: 264–5PubMedCrossRef Busenbark K, Barnes P, Lyons K, et al. Accuracy of reported family histories of essential tremor. Neurology 1996; 47: 264–5PubMedCrossRef
122.
go back to reference Tanner CM, Goldman SM, Lyons KE, et al. Essential tremor in twins: an assessment of genetic vs environmental determinants of etiology. Neurology 2001; 57: 1389–91PubMedCrossRef Tanner CM, Goldman SM, Lyons KE, et al. Essential tremor in twins: an assessment of genetic vs environmental determinants of etiology. Neurology 2001; 57: 1389–91PubMedCrossRef
123.
go back to reference Lorenz D, Frederiksen H, Moises H, et al. High concordance for essential tremor in monozygotic twins of old age. Neurology 2004; 62: 208–11PubMedCrossRef Lorenz D, Frederiksen H, Moises H, et al. High concordance for essential tremor in monozygotic twins of old age. Neurology 2004; 62: 208–11PubMedCrossRef
124.
go back to reference Lorenz D, Klebe S, Stevanin G, et al. Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients. Eur J Hum Genet 2009; 17: 766–73PubMedCrossRef Lorenz D, Klebe S, Stevanin G, et al. Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients. Eur J Hum Genet 2009; 17: 766–73PubMedCrossRef
125.
go back to reference Louis ED, Vonsattel JP. The emerging neuropathology of essential tremor. Mov Disord 2008; 23: 174–82PubMedCrossRef Louis ED, Vonsattel JP. The emerging neuropathology of essential tremor. Mov Disord 2008; 23: 174–82PubMedCrossRef
126.
go back to reference Litvan I, MacIntyre A, Goetz CG, et al. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol 1998; 55: 969–78PubMedCrossRef Litvan I, MacIntyre A, Goetz CG, et al. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol 1998; 55: 969–78PubMedCrossRef
127.
go back to reference Stockner H, Sojer M, Seppi K, et al. Midbrain sonography in patients with essential tremor. Mov Disord 2007; 22: 414–7PubMedCrossRef Stockner H, Sojer M, Seppi K, et al. Midbrain sonography in patients with essential tremor. Mov Disord 2007; 22: 414–7PubMedCrossRef
128.
go back to reference Louis ED, Faust PL, Vonsattel JP, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007; 130: 3297–307PubMedCrossRef Louis ED, Faust PL, Vonsattel JP, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007; 130: 3297–307PubMedCrossRef
129.
go back to reference Rajput A, Robinson CA, Rajput AH. Essential tremor course and disability: a clinicopathologic study of 20 cases. Neurology 2004; 62: 932–6PubMedCrossRef Rajput A, Robinson CA, Rajput AH. Essential tremor course and disability: a clinicopathologic study of 20 cases. Neurology 2004; 62: 932–6PubMedCrossRef
130.
go back to reference Lorenz D, Deuschl G. Update on pathogenesis and treatment of essential tremor. Curr Opin Neurol 2007; 20: 447–52PubMedCrossRef Lorenz D, Deuschl G. Update on pathogenesis and treatment of essential tremor. Curr Opin Neurol 2007; 20: 447–52PubMedCrossRef
131.
go back to reference Kondziolka D, Ong JG, Lee JY, et al. Gamma Knife thalamotomy for essential tremor. J Neurosurg 2008; 108: 111–7PubMedCrossRef Kondziolka D, Ong JG, Lee JY, et al. Gamma Knife thalamotomy for essential tremor. J Neurosurg 2008; 108: 111–7PubMedCrossRef
132.
go back to reference Pahwa R, Lyons KE, Wilkinson SB, et al. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg 2006; 104: 506–12PubMedCrossRef Pahwa R, Lyons KE, Wilkinson SB, et al. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg 2006; 104: 506–12PubMedCrossRef
133.
go back to reference Dupuis MJ, Delwaide PJ, Boucquey D, et al. Homolateral disappearance of essential tremor after cerebellar stroke. Mov Disord 1989; 4: 183–7PubMedCrossRef Dupuis MJ, Delwaide PJ, Boucquey D, et al. Homolateral disappearance of essential tremor after cerebellar stroke. Mov Disord 1989; 4: 183–7PubMedCrossRef
134.
go back to reference Chahine LM, Ghosh D. Essential tremor after ipsilateral cerebellar hemispherectomy: support for the thalamus as the central oscillator. J Child Neurol. Epub 2009 Feb 2 Chahine LM, Ghosh D. Essential tremor after ipsilateral cerebellar hemispherectomy: support for the thalamus as the central oscillator. J Child Neurol. Epub 2009 Feb 2
136.
go back to reference Long MA, Deans MR, Paul DL, et al. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci 2002; 22: 10898–905PubMed Long MA, Deans MR, Paul DL, et al. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci 2002; 22: 10898–905PubMed
137.
go back to reference Martin FC, Thu Le A, Handforth A. Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. Mov Disord 2005; 20: 298–305PubMedCrossRef Martin FC, Thu Le A, Handforth A. Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. Mov Disord 2005; 20: 298–305PubMedCrossRef
138.
139.
go back to reference Jiménez-Jiménez FJ, de Toledo-Heras M, Alonso-Navarro H, et al. Environmental risk factors for essential tremor. Eur Neurol 2007; 58: 106–13PubMed Jiménez-Jiménez FJ, de Toledo-Heras M, Alonso-Navarro H, et al. Environmental risk factors for essential tremor. Eur Neurol 2007; 58: 106–13PubMed
140.
go back to reference Scarmeas N, Louis ED. Mediterranean diet and essential tremor: a case-control study. Neuroepidemiology 2007; 29: 170–7PubMedCrossRef Scarmeas N, Louis ED. Mediterranean diet and essential tremor: a case-control study. Neuroepidemiology 2007; 29: 170–7PubMedCrossRef
141.
go back to reference Louis ED, Keating GA, Bogen KT, et al. Dietary epidemiology of essential tremor: meat consumption and meat cooking practices. Neuroepidemiology 2008; 30: 161–6PubMedCrossRef Louis ED, Keating GA, Bogen KT, et al. Dietary epidemiology of essential tremor: meat consumption and meat cooking practices. Neuroepidemiology 2008; 30: 161–6PubMedCrossRef
142.
go back to reference Louis ED, Benito-Leon J, Bermejo-Pareja F. Population-based study of baseline ethanol consumption and risk of incident essential tremor. J Neurol Neurosurg Psychiatry 2009; 80: 494–7PubMedCrossRef Louis ED, Benito-Leon J, Bermejo-Pareja F. Population-based study of baseline ethanol consumption and risk of incident essential tremor. J Neurol Neurosurg Psychiatry 2009; 80: 494–7PubMedCrossRef
143.
go back to reference Louis ED, Benito-Leon J, Bermejo-Pareja F. Population-based prospective study of cigarette smoking and risk of incident essential tremor. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2008; 70: 1682–7PubMedCrossRef Louis ED, Benito-Leon J, Bermejo-Pareja F. Population-based prospective study of cigarette smoking and risk of incident essential tremor. Neurological Disorders in Central Spain (NEDICES) Study Group. Neurology 2008; 70: 1682–7PubMedCrossRef
144.
go back to reference Koller WC, Hristova A, Brin M. Pharmacologic treatment of essential tremor. Neurology 2000; 54Suppl. 4: S30–8PubMed Koller WC, Hristova A, Brin M. Pharmacologic treatment of essential tremor. Neurology 2000; 54Suppl. 4: S30–8PubMed
145.
go back to reference Zesiewicz TA, Elble R, Louis ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64: 2008–20PubMedCrossRef Zesiewicz TA, Elble R, Louis ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64: 2008–20PubMedCrossRef
146.
go back to reference Pritchard B, Gillam P. Use of propranolol (Inderal) in treatment of hypertension. BMJ 1964; 2: 725–8CrossRef Pritchard B, Gillam P. Use of propranolol (Inderal) in treatment of hypertension. BMJ 1964; 2: 725–8CrossRef
147.
go back to reference Winkler GF, Young RR. The control of essential tremor by propranolol. Trans Am Neurol Assoc 1971; 96: 66–8PubMed Winkler GF, Young RR. The control of essential tremor by propranolol. Trans Am Neurol Assoc 1971; 96: 66–8PubMed
148.
go back to reference Leigh PN, Jefferson D, Twomey A, et al. Beta-adrenoreceptor mechanisms in essential tremor; a double-blind placebo controlled trial of metoprolol, sotalol and atenolol. J Neurol Neurosurg Psychiatry 1983; 46: 710–5PubMedCrossRef Leigh PN, Jefferson D, Twomey A, et al. Beta-adrenoreceptor mechanisms in essential tremor; a double-blind placebo controlled trial of metoprolol, sotalol and atenolol. J Neurol Neurosurg Psychiatry 1983; 46: 710–5PubMedCrossRef
149.
go back to reference Abila B, Wilson JF, Marshall RW, et al. The tremorolytic action of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is mediated by beta-adrenoceptors located in a deep peripheral compartment. Br J Clin Pharmacol 1985; 20: 369–76PubMedCrossRef Abila B, Wilson JF, Marshall RW, et al. The tremorolytic action of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is mediated by beta-adrenoceptors located in a deep peripheral compartment. Br J Clin Pharmacol 1985; 20: 369–76PubMedCrossRef
150.
go back to reference Cleeves L, Findley LJ. Propranolol and propranolol-LA in essential tremor: a double blind comparative study. J Neurol Neurosurg Psychiatry 1988; 51: 379–84PubMedCrossRef Cleeves L, Findley LJ. Propranolol and propranolol-LA in essential tremor: a double blind comparative study. J Neurol Neurosurg Psychiatry 1988; 51: 379–84PubMedCrossRef
151.
go back to reference Koller WC, Vetere-Overfield B. Acute and chronic effects of propranolol and primidone in essential tremor. Neurology 1989; 39: 1587–8PubMedCrossRef Koller WC, Vetere-Overfield B. Acute and chronic effects of propranolol and primidone in essential tremor. Neurology 1989; 39: 1587–8PubMedCrossRef
152.
go back to reference Handley R, Stewart AS. Mysoline: a new drug in the treatment of epilepsy. Lancet 1952; I: 742–4CrossRef Handley R, Stewart AS. Mysoline: a new drug in the treatment of epilepsy. Lancet 1952; I: 742–4CrossRef
153.
go back to reference O’Brien MD, Upton AR, Toseland PA. Benign familial tremor treated with primidone. BMJ (Clin Res Ed) 1981; 282: 178–80CrossRef O’Brien MD, Upton AR, Toseland PA. Benign familial tremor treated with primidone. BMJ (Clin Res Ed) 1981; 282: 178–80CrossRef
154.
155.
go back to reference Sasso E, Perucca E, Calzetti S. Double-blind comparison of primidone and phenobarbital in essential tremor. Neurology 1988; 38: 808–10PubMedCrossRef Sasso E, Perucca E, Calzetti S. Double-blind comparison of primidone and phenobarbital in essential tremor. Neurology 1988; 38: 808–10PubMedCrossRef
156.
go back to reference Calzetti S, Findley LJ, Pisani F, et al. Phenylethylmalonamide in essential tremor: a double-blind controlled study. J Neurol Neurosurg Psychiatry 1981; 44: 932–4PubMedCrossRef Calzetti S, Findley LJ, Pisani F, et al. Phenylethylmalonamide in essential tremor: a double-blind controlled study. J Neurol Neurosurg Psychiatry 1981; 44: 932–4PubMedCrossRef
157.
158.
go back to reference Findley LJ, Cleeves L, Calzetti S. Primidone in essential tremor of the hands and head: a double blind controlled clinical study. J Neurol Neurosurg Psychiatry 1985; 48: 911–5PubMedCrossRef Findley LJ, Cleeves L, Calzetti S. Primidone in essential tremor of the hands and head: a double blind controlled clinical study. J Neurol Neurosurg Psychiatry 1985; 48: 911–5PubMedCrossRef
159.
go back to reference O’Suilleabhain P, Dewey RB. Randomized trial comparing primidone initiation schedules for treating essential tremor. Mov Disord 2002; 17: 383–6CrossRef O’Suilleabhain P, Dewey RB. Randomized trial comparing primidone initiation schedules for treating essential tremor. Mov Disord 2002; 17: 383–6CrossRef
160.
161.
go back to reference Gissel T, Poulsen CS, Vestergaard P. Adverse effects of antiepileptic drugs on bone mineral density in children. Expert Opin Drug Saf 2007; 6: 267–78PubMedCrossRef Gissel T, Poulsen CS, Vestergaard P. Adverse effects of antiepileptic drugs on bone mineral density in children. Expert Opin Drug Saf 2007; 6: 267–78PubMedCrossRef
162.
go back to reference Klebe S, Stolze H, Grensing K, et al. Influence of alcohol on gait in patients with essential tremor. Neurology 2005; 65: 96–101PubMedCrossRef Klebe S, Stolze H, Grensing K, et al. Influence of alcohol on gait in patients with essential tremor. Neurology 2005; 65: 96–101PubMedCrossRef
163.
go back to reference Ondo WG, Jankovic J, Connor GS, et al. Topiramate in essential tremor: a double-blind, placebo-controlled trial. Neurology 2006; 66: 672–7PubMedCrossRef Ondo WG, Jankovic J, Connor GS, et al. Topiramate in essential tremor: a double-blind, placebo-controlled trial. Neurology 2006; 66: 672–7PubMedCrossRef
164.
go back to reference Pahwa R, Busenbark K, Swanson-Hyland EF, et al. Botulinum toxin treatment of essential head tremor. Neurology 1995; 45: 822–4PubMedCrossRef Pahwa R, Busenbark K, Swanson-Hyland EF, et al. Botulinum toxin treatment of essential head tremor. Neurology 1995; 45: 822–4PubMedCrossRef
165.
go back to reference Jankovic J, Schwartz K, Clemence W, et al. A randomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor. Mov Disord 1996; 11: 250–6PubMedCrossRef Jankovic J, Schwartz K, Clemence W, et al. A randomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor. Mov Disord 1996; 11: 250–6PubMedCrossRef
166.
go back to reference Brin MF, Lyons KE, Doucette J, et al. A randomized, double masked, controlled trial of botulinum toxin type A in essential hand tremor. Neurology 2001; 56: 1523–8PubMedCrossRef Brin MF, Lyons KE, Doucette J, et al. A randomized, double masked, controlled trial of botulinum toxin type A in essential hand tremor. Neurology 2001; 56: 1523–8PubMedCrossRef
167.
go back to reference Warrick P, Dromey C, Irish JC, et al. Botulinum toxin for essential tremor of the voice with multiple anatomical sites of tremor: a crossover design study of unilateral versus bilateral injection. Laryngoscope 2000; 110: 1366–74PubMedCrossRef Warrick P, Dromey C, Irish JC, et al. Botulinum toxin for essential tremor of the voice with multiple anatomical sites of tremor: a crossover design study of unilateral versus bilateral injection. Laryngoscope 2000; 110: 1366–74PubMedCrossRef
168.
go back to reference Stacy M, Jankovic J. Childhood dystonia. Pediatr Ann 1993; 22: 53–8PubMed Stacy M, Jankovic J. Childhood dystonia. Pediatr Ann 1993; 22: 53–8PubMed
169.
go back to reference Kwak CH, Hanna PA, Jankovic J. Botulinum toxin in the treatment of tics. Arch Neurol 2000; 57: 1190–3PubMedCrossRef Kwak CH, Hanna PA, Jankovic J. Botulinum toxin in the treatment of tics. Arch Neurol 2000; 57: 1190–3PubMedCrossRef
170.
go back to reference Kenney C, Simpson R, Hunter C, et al. Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders. J Neurosurg 2007; 106: 621–5PubMedCrossRef Kenney C, Simpson R, Hunter C, et al. Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders. J Neurosurg 2007; 106: 621–5PubMedCrossRef
171.
go back to reference Peña C, Bowsher K, Samuels-Reid J. FDA-approved neurologic devices intended for use in infants, children, and adolescents. Neurology 2004; 63: 1163–7PubMedCrossRef Peña C, Bowsher K, Samuels-Reid J. FDA-approved neurologic devices intended for use in infants, children, and adolescents. Neurology 2004; 63: 1163–7PubMedCrossRef
172.
go back to reference Umemura A, Samadani U, Jaggi JL, et al. Thalamic deep brain stimulation for posttraumatic action tremor. Clin Neurol Neurosurg 2004; 106: 280–3PubMedCrossRef Umemura A, Samadani U, Jaggi JL, et al. Thalamic deep brain stimulation for posttraumatic action tremor. Clin Neurol Neurosurg 2004; 106: 280–3PubMedCrossRef
173.
go back to reference Thompson TP, Kondziolka D, Albright AL. Thalamic stimulation for choreiform movement disorders in children: report of two cases. J Neurosurg 2000; 92: 718–21PubMedCrossRef Thompson TP, Kondziolka D, Albright AL. Thalamic stimulation for choreiform movement disorders in children: report of two cases. J Neurosurg 2000; 92: 718–21PubMedCrossRef
Metadata
Title
Epidemiology and Management of Essential Tremor in Children
Authors
Joseph Ferrara
Dr Joseph Jankovic
Publication date
01-10-2009
Publisher
Springer International Publishing
Published in
Pediatric Drugs / Issue 5/2009
Print ISSN: 1174-5878
Electronic ISSN: 1179-2019
DOI
https://doi.org/10.2165/11316050-000000000-00000

Other articles of this Issue 5/2009

Pediatric Drugs 5/2009 Go to the issue