Skip to main content
Top
Published in: BMC Nephrology 1/2012

Open Access 01-12-2012 | Research article

Epidemiology and aetiology of dialysis-treated end-stage kidney disease in Libya

Authors: Wiam A Alashek, Christopher W McIntyre, Maarten W Taal

Published in: BMC Nephrology | Issue 1/2012

Login to get access

Abstract

Background

The extent and the distribution of end stage kidney disease (ESKD) in Libya have not been reported despite provision of dialysis over 4 decades. This study aimed to develop the first comprehensive description of the epidemiology of dialysis-treated ESKD in Libya.

Methods

Structured demographic and clinical data were obtained regarding all adult patients treated at all maintenance dialysis facilities (n=39) in Libya from May to September 2009. Subsequently data were collected prospectively on all new patients who started dialysis from September 2009 to August 2010. Population estimates were obtained from the Libyan national statistics department. The age and gender breakdown of the population in each region was obtained from mid-2009 population estimates based on 2006 census data.

Results

The prevalence of dialysis-treated ESKD was 624 per million population (pmp). 85% of prevalent patients were aged <65 years and 58% were male. The prevalence of ESKD varied considerably with age with a peak at 55–64 years (2475 pmp for males; 2197 pmp for females). The annual incidence rate was 282 pmp with some regional variation and a substantially higher rate in the South (617 pmp). The most common cause of ESKD among prevalent and incident patients was diabetes. Other important causes were glomerulonephritis, hypertensive nephropathy and congenital or hereditary diseases.

Conclusions

Libya has a relatively high prevalence and incidence of dialysis-treated ESKD. As the country prepares to redevelop its healthcare system it is hoped that these data will guide strategies for the prevention of CKD and planning for the provision of renal replacement therapy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Rao GM: Diabetes mellitus in Libya: a retrospective study. Indian J Med Sci. 1992, 46 (6): 174-181.PubMed Rao GM: Diabetes mellitus in Libya: a retrospective study. Indian J Med Sci. 1992, 46 (6): 174-181.PubMed
2.
go back to reference The National Board for Scientific Research T-L: Risk factors for hypertension. . 2001, 32-39. The National Board for Scientific Research T-L: Risk factors for hypertension. . 2001, 32-39.
3.
go back to reference Roaeid RB, Kablan AA: Diabetes mortality and causes of death in Benghazi: a 5-year retrospective analysis of death certificates. East Mediterr Health J. 2010, 16 (1): 65-69.PubMed Roaeid RB, Kablan AA: Diabetes mortality and causes of death in Benghazi: a 5-year retrospective analysis of death certificates. East Mediterr Health J. 2010, 16 (1): 65-69.PubMed
4.
go back to reference Kadiki OA, Roaeid RB: Prevalence of diabetes mellitus and impaired glucose tolerance in Benghazi Libya. Diabetes Metab. 2001, 27 (6): 647-654.PubMed Kadiki OA, Roaeid RB: Prevalence of diabetes mellitus and impaired glucose tolerance in Benghazi Libya. Diabetes Metab. 2001, 27 (6): 647-654.PubMed
6.
go back to reference Salam AA, Alshekteria AA, Abd Alhadi H, Ahmed M, Mohammed A: Patient satisfaction with quality of primary health care in Benghazi, Libya. Libyan J Med. 2010, 5: doi:10.3402/ljm.v5i0.4873. Salam AA, Alshekteria AA, Abd Alhadi H, Ahmed M, Mohammed A: Patient satisfaction with quality of primary health care in Benghazi, Libya. Libyan J Med. 2010, 5: doi:10.3402/ljm.v5i0.4873.
7.
go back to reference Alashek WA, McIntyre CW, Taal MW: Provision and quality of dialysis services in Libya. Hemodial Int. 2011, 15 (4): 444-452. 10.1111/j.1542-4758.2011.00588.x.CrossRefPubMed Alashek WA, McIntyre CW, Taal MW: Provision and quality of dialysis services in Libya. Hemodial Int. 2011, 15 (4): 444-452. 10.1111/j.1542-4758.2011.00588.x.CrossRefPubMed
8.
go back to reference Usta A, Shawish T, Mishra A, Ehtuish EF, Ajaj H, Milud N, Shebani A, Abdulmola T, Tejori U: Living related kidney transplantation in Libya: a single center experience. Transplant Proc. 2008, 40 (10): 3428-3433. 10.1016/j.transproceed.2008.06.063.CrossRefPubMed Usta A, Shawish T, Mishra A, Ehtuish EF, Ajaj H, Milud N, Shebani A, Abdulmola T, Tejori U: Living related kidney transplantation in Libya: a single center experience. Transplant Proc. 2008, 40 (10): 3428-3433. 10.1016/j.transproceed.2008.06.063.CrossRefPubMed
9.
go back to reference Ehtuish EF, Abouna GM, Shebani AH, Abdulmola TS, Shawesh TZ: Kidney transplantation in Libya: a North African and Middle Eastern perspective. Exp Clin Transplant. 2006, 4 (1): 425-428.PubMed Ehtuish EF, Abouna GM, Shebani AH, Abdulmola TS, Shawesh TZ: Kidney transplantation in Libya: a North African and Middle Eastern perspective. Exp Clin Transplant. 2006, 4 (1): 425-428.PubMed
10.
go back to reference Abboud O: Incidence, prevalence, and treatment of end-stage renal disease in the Middle East. Ethn Dis. 2006, 16 (2 Suppl 2): S2-2-4-PubMed Abboud O: Incidence, prevalence, and treatment of end-stage renal disease in the Middle East. Ethn Dis. 2006, 16 (2 Suppl 2): S2-2-4-PubMed
11.
go back to reference Najafi I: Peritoneal dialysis in iran and the middle East. Perit Dial Int. 2009, 29 (Suppl 2): S217-S221.PubMed Najafi I: Peritoneal dialysis in iran and the middle East. Perit Dial Int. 2009, 29 (Suppl 2): S217-S221.PubMed
13.
go back to reference El Minshawy O: End-stage renal disease in the El-Minia Governorate, upper Egypt: an epidemiological study. Saudi J Kidney Dis Transpl. 2011, 22 (5): 1048-1054.PubMed El Minshawy O: End-stage renal disease in the El-Minia Governorate, upper Egypt: an epidemiological study. Saudi J Kidney Dis Transpl. 2011, 22 (5): 1048-1054.PubMed
14.
go back to reference Alashek W, Ehtuish E, Elhabashi A, Emberish W, Mishra A: Reasons for unwillingness of libyans to donate organs after death. Libyan J Med. 2009, 4 (3): 110-113.CrossRefPubMedPubMedCentral Alashek W, Ehtuish E, Elhabashi A, Emberish W, Mishra A: Reasons for unwillingness of libyans to donate organs after death. Libyan J Med. 2009, 4 (3): 110-113.CrossRefPubMedPubMedCentral
15.
16.
go back to reference Shigidi MM, Ramachandiran G, Rashed AH, Fituri OM: Demographic data and hemodialysis population dynamics in Qatar: a five year survey. Saudi J Kidney Dis Transpl. 2009, 20 (3): 493-500.PubMed Shigidi MM, Ramachandiran G, Rashed AH, Fituri OM: Demographic data and hemodialysis population dynamics in Qatar: a five year survey. Saudi J Kidney Dis Transpl. 2009, 20 (3): 493-500.PubMed
17.
go back to reference Counil E, Cherni N, Kharrat M, Achour A, Trimech H: Trends of incident dialysis patients in Tunisia between 1992 and 2001. Am J Kidney Dis. 2008, 51 (3): 463-470. 10.1053/j.ajkd.2007.10.032.CrossRefPubMed Counil E, Cherni N, Kharrat M, Achour A, Trimech H: Trends of incident dialysis patients in Tunisia between 1992 and 2001. Am J Kidney Dis. 2008, 51 (3): 463-470. 10.1053/j.ajkd.2007.10.032.CrossRefPubMed
18.
go back to reference Prabahar MR, Chandrasekaran V, Soundararajan P: Epidemic of chronic kidney disease in India -what can be done?. Saudi J Kidney Dis Transpl. 2008, 19 (5): 847-853.PubMed Prabahar MR, Chandrasekaran V, Soundararajan P: Epidemic of chronic kidney disease in India -what can be done?. Saudi J Kidney Dis Transpl. 2008, 19 (5): 847-853.PubMed
20.
go back to reference Batieha A, Abdallah S, Maghaireh M, Awad Z, Al-Akash N, Batieneh A, Ajlouni KA: Epidemiology and cost of haemodialysis in Jordan. East Mediterr Health J. 2007, 13 (3): 654-663.PubMed Batieha A, Abdallah S, Maghaireh M, Awad Z, Al-Akash N, Batieneh A, Ajlouni KA: Epidemiology and cost of haemodialysis in Jordan. East Mediterr Health J. 2007, 13 (3): 654-663.PubMed
21.
go back to reference Moukeh G, Yacoub R, Fahdi F, Rastam S, Albitar S: Epidemiology of hemodialysis patients in Aleppo city. Saudi J Kidney Dis Transpl. 2009, 20 (1): 140-146.PubMed Moukeh G, Yacoub R, Fahdi F, Rastam S, Albitar S: Epidemiology of hemodialysis patients in Aleppo city. Saudi J Kidney Dis Transpl. 2009, 20 (1): 140-146.PubMed
22.
go back to reference Mathur AK, Ashby VB, Sands RL, Wolfe RA: Geographic variation in end-stage renal disease incidence and access to deceased donor kidney transplantation. Am J Transplant. 2010, 10 (4 Pt 2): 1069-1080.CrossRefPubMed Mathur AK, Ashby VB, Sands RL, Wolfe RA: Geographic variation in end-stage renal disease incidence and access to deceased donor kidney transplantation. Am J Transplant. 2010, 10 (4 Pt 2): 1069-1080.CrossRefPubMed
23.
go back to reference Wimmer F, Oberaigner W, Kramar R, Mayer G: Regional variability in the incidence of end-stage renal disease: an epidemiological approach. Nephrol Dial Transplant. 2003, 18 (8): 1562-1567. 10.1093/ndt/gfg184.CrossRefPubMed Wimmer F, Oberaigner W, Kramar R, Mayer G: Regional variability in the incidence of end-stage renal disease: an epidemiological approach. Nephrol Dial Transplant. 2003, 18 (8): 1562-1567. 10.1093/ndt/gfg184.CrossRefPubMed
24.
go back to reference Steenkamp R, Castledine C, Feest T, Fogarty D: UK Renal Registry 13th Annual Report (December 2010): chapter 2: UK RRT Prevalence in 2009: national and centre-specific analyses. . 2010, UK Renal Registry, Bristol, 35-60. Steenkamp R, Castledine C, Feest T, Fogarty D: UK Renal Registry 13th Annual Report (December 2010): chapter 2: UK RRT Prevalence in 2009: national and centre-specific analyses. . 2010, UK Renal Registry, Bristol, 35-60.
25.
go back to reference Collins AJ, Foley RN, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, et al: United States renal data system 2008 annual data report. Am J Kidney Dis. 2009, 53 (1 Suppl): S1-S374. Collins AJ, Foley RN, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, et al: United States renal data system 2008 annual data report. Am J Kidney Dis. 2009, 53 (1 Suppl): S1-S374.
26.
go back to reference Gilg J, Castledine C, Fogarty D, Feest T: UK Renal Registry 13th Annual Report (December 2010): chapter 1: UK RRT Incidence in 2009: national and centre-specific analyses. . 2010, UK Renal Registry, , 9-33. Gilg J, Castledine C, Fogarty D, Feest T: UK Renal Registry 13th Annual Report (December 2010): chapter 1: UK RRT Incidence in 2009: national and centre-specific analyses. . 2010, UK Renal Registry, , 9-33.
27.
go back to reference Goodkin DA, Young EW, Kurokawa K, Prutz KG, Levin NW: Mortality among hemodialysis patients in Europe, Japan, and the United States: case-mix effects. Am J Kidney Dis. 2004, 44 (5 Suppl 2): 16-21.CrossRefPubMed Goodkin DA, Young EW, Kurokawa K, Prutz KG, Levin NW: Mortality among hemodialysis patients in Europe, Japan, and the United States: case-mix effects. Am J Kidney Dis. 2004, 44 (5 Suppl 2): 16-21.CrossRefPubMed
28.
go back to reference Iseki K, Nakai S, Shinzato T, Nagura Y, Akiba T: Increasing gender difference in the incidence of chronic dialysis therapy in Japan. Ther Apher Dial. 2005, 9 (5): 407-411. 10.1111/j.1744-9987.2005.00318.x.CrossRefPubMed Iseki K, Nakai S, Shinzato T, Nagura Y, Akiba T: Increasing gender difference in the incidence of chronic dialysis therapy in Japan. Ther Apher Dial. 2005, 9 (5): 407-411. 10.1111/j.1744-9987.2005.00318.x.CrossRefPubMed
29.
30.
go back to reference Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004, 27 (5): 1047-1053. 10.2337/diacare.27.5.1047.CrossRefPubMed Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004, 27 (5): 1047-1053. 10.2337/diacare.27.5.1047.CrossRefPubMed
31.
go back to reference Belqacem S: Health issues in the Arab American community. Commentary: the growing risk factors for noncommunicable diseases in the Arab world. Ethn Dis. 2007, 17 (2 Suppl 3): S3-51-S53-52. Belqacem S: Health issues in the Arab American community. Commentary: the growing risk factors for noncommunicable diseases in the Arab world. Ethn Dis. 2007, 17 (2 Suppl 3): S3-51-S53-52.
32.
go back to reference Khogali M: Health and disease in a changing Arab world 2000/2025/2050: global, environmental, and climate change and emerging diseases. Ethn Dis. 2005, 15 (1 Suppl 1): S1-74-75- Khogali M: Health and disease in a changing Arab world 2000/2025/2050: global, environmental, and climate change and emerging diseases. Ethn Dis. 2005, 15 (1 Suppl 1): S1-74-75-
33.
go back to reference Iseki K: Factors influencing the development of end-stage renal disease. Clin Exp Nephrol. 2005, 9 (1): 5-14. 10.1007/s10157-005-0341-3.CrossRefPubMed Iseki K: Factors influencing the development of end-stage renal disease. Clin Exp Nephrol. 2005, 9 (1): 5-14. 10.1007/s10157-005-0341-3.CrossRefPubMed
34.
go back to reference Farag Y, Al Wakeel J: Diabetic Nephropathy in the Arab Gulf Countries. Nephron Clin Pract. 2011, 119 (4): c317-c323. 10.1159/000328909.CrossRefPubMed Farag Y, Al Wakeel J: Diabetic Nephropathy in the Arab Gulf Countries. Nephron Clin Pract. 2011, 119 (4): c317-c323. 10.1159/000328909.CrossRefPubMed
35.
go back to reference Kramer H: Screening for kidney disease in adults with diabetes and prediabetes. Curr Opin Nephrol Hypertens. 2005, 14 (3): 249-252. 10.1097/01.mnh.0000165891.67878.7f.CrossRefPubMed Kramer H: Screening for kidney disease in adults with diabetes and prediabetes. Curr Opin Nephrol Hypertens. 2005, 14 (3): 249-252. 10.1097/01.mnh.0000165891.67878.7f.CrossRefPubMed
36.
go back to reference Zhang AH, Zhong H, Tang W, Chen SY, He L, Wang S, Su CY, Lu XH, Wang T: Establishing a renal management clinic in China: initiative, challenges, and opportunities. Int Urol Nephrol. 2008, 40 (4): 1053-1058. 10.1007/s11255-008-9450-8.CrossRefPubMed Zhang AH, Zhong H, Tang W, Chen SY, He L, Wang S, Su CY, Lu XH, Wang T: Establishing a renal management clinic in China: initiative, challenges, and opportunities. Int Urol Nephrol. 2008, 40 (4): 1053-1058. 10.1007/s11255-008-9450-8.CrossRefPubMed
37.
go back to reference El-Reshaid W, El-Reshaid K, Kapoor M, Hakim A: Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years. Ren Fail. 2005, 27 (2): 227-233.CrossRefPubMed El-Reshaid W, El-Reshaid K, Kapoor M, Hakim A: Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years. Ren Fail. 2005, 27 (2): 227-233.CrossRefPubMed
39.
go back to reference Badheeb AM: Causes of chronic renal failure in hemodialysis unit: a single center experience in Yemen. Saudi J Kidney Dis Transpl. 2006, 17 (1): 66-69.PubMed Badheeb AM: Causes of chronic renal failure in hemodialysis unit: a single center experience in Yemen. Saudi J Kidney Dis Transpl. 2006, 17 (1): 66-69.PubMed
40.
go back to reference Gooneratne IK, Ranaweera AK, Liyanarachchi NP, Gunawardane N, Lanerolle RD: Epidemiology of chronic kidney disease in a Sri Lankan population. Int J Diabetes Dev Ctries. 2008, 28 (2): 60-64. 10.4103/0973-3930.43101.CrossRefPubMedPubMedCentral Gooneratne IK, Ranaweera AK, Liyanarachchi NP, Gunawardane N, Lanerolle RD: Epidemiology of chronic kidney disease in a Sri Lankan population. Int J Diabetes Dev Ctries. 2008, 28 (2): 60-64. 10.4103/0973-3930.43101.CrossRefPubMedPubMedCentral
41.
go back to reference Rizvi SA, Manzoor K: Causes of chronic renal failure in pakistan: a single large center experience. Saudi J Kidney Dis Transpl. 2002, 13 (3): 376-379.PubMed Rizvi SA, Manzoor K: Causes of chronic renal failure in pakistan: a single large center experience. Saudi J Kidney Dis Transpl. 2002, 13 (3): 376-379.PubMed
42.
go back to reference Teebi AS, Teebi SA, Porter CJ, Cuticchia AJ: Arab genetic disease database (AGDDB): a population-specific clinical and mutation database. Hum Mutat. 2002, 19 (6): 615-621. 10.1002/humu.10082.CrossRefPubMed Teebi AS, Teebi SA, Porter CJ, Cuticchia AJ: Arab genetic disease database (AGDDB): a population-specific clinical and mutation database. Hum Mutat. 2002, 19 (6): 615-621. 10.1002/humu.10082.CrossRefPubMed
43.
go back to reference Barbari A, Stephan A, Masri M, Karam A, Aoun S, El Nahas J, Bou Khalil J: Consanguinity-associated kidney diseases in Lebanon: an epidemiological study. Mol Immunol. 2003, 39 (17–18): 1109-1114.CrossRefPubMed Barbari A, Stephan A, Masri M, Karam A, Aoun S, El Nahas J, Bou Khalil J: Consanguinity-associated kidney diseases in Lebanon: an epidemiological study. Mol Immunol. 2003, 39 (17–18): 1109-1114.CrossRefPubMed
44.
go back to reference Hoodfar E, Teebi AS: Genetic referrals of Middle Eastern origin in a western city: inbreeding and disease profile. J Med Genet. 1996, 33 (3): 212-215. 10.1136/jmg.33.3.212.CrossRefPubMedPubMedCentral Hoodfar E, Teebi AS: Genetic referrals of Middle Eastern origin in a western city: inbreeding and disease profile. J Med Genet. 1996, 33 (3): 212-215. 10.1136/jmg.33.3.212.CrossRefPubMedPubMedCentral
Metadata
Title
Epidemiology and aetiology of dialysis-treated end-stage kidney disease in Libya
Authors
Wiam A Alashek
Christopher W McIntyre
Maarten W Taal
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2012
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/1471-2369-13-33

Other articles of this Issue 1/2012

BMC Nephrology 1/2012 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine