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01-06-2010 | Review

Enzymatic disease of the podocyte

Authors: Andreas D. Kistler, Vasil Peev, Anna-Lena Forst, Shafic El Hindi, Mehmet M. Altintas, Jochen Reiser

Published in: Pediatric Nephrology | Issue 6/2010

Abstract

Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter. A few genes have been identified that explain genetic glomerular failure and recent insights shed light on the pathogenesis of acquired proteinuric diseases. This review highlights the unique role of the cysteine protease cathepsin L as a regulatory rather than a digestive protease and its action on podocyte structure and function. We provide arguments why many glomerular diseases can be regarded as podocyte enzymatic disorders.

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Title: Enzymatic disease of the podocyte
Authors: Andreas D. Kistler
Vasil Peev
Anna-Lena Forst
Shafic El Hindi
Mehmet M. Altintas
Jochen Reiser
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 6/2010
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1425-1

At a glance: The STEP trials

Springer Medicine

Enzymatic disease of the podocyte

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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