Skip to main content
Top
Published in: International Journal of Colorectal Disease 12/2019

01-12-2019 | Enterostomy | Original Article

Laparoscopic peritoneal lavage versus laparoscopic sigmoidectomy in complicated acute diverticulitis: a multicenter prospective observational study

Authors: Dario Tartaglia, Salomone Di Saverio, Weronika Stupalkowska, Sandro Giannessi, Virna Robustelli, Federico Coccolini, Orestis Ioannidis, Gabriela Elisa Nita, Virginia María Durán Muñoz-Cruzado, Felipe Pareja Ciuró, Massimo Chiarugi

Published in: International Journal of Colorectal Disease | Issue 12/2019

Login to get access

Abstract

Purpose

Laparoscopic peritoneal lavage (LPL) is feasible in selected patients with pelvic abscess and generalized purulent peritonitis caused by acute diverticulitis. We aimed to compare LPL and laparoscopic sigmoidectomy (LS) in complicated acute diverticulitis.

Methods

This prospective, observational, multicenter study included patients with a pelvic abscess not amenable to conservative management and patients with Hinchey III acute diverticulitis, from 2015 to 2018. Sixty-six patients were enrolled: 28 (42%) underwent LPL and 38 (58%) underwent LS. In LS, patients had a primary anastomosis, with or without ileostomy, or an end colostomy (HA). Major outcomes were mortality, morbidity, failure of source control, reoperation, length of stay, and diverticulitis recurrence.

Results

Patient demographics were similar in the two groups. In LPL, ASA score > 2 and Mannheim Peritonitis Index were significantly higher (p = 0.05 and 0.004). In LS, 24 patients (63%) had a PA and 14 (37%) an HA. No death was recorded. Overall, morbidity was 33% in LPL and 18% in LS (p = 0.169). However, failure to achieve source control of the peritoneal infection and the need to return to the operating room were more frequent in LPL (p = 0.002 and p = 0.006). Mean postoperative length of stay was comparable (p = 0.08). Diverticular recurrence was significantly higher in LPL (p = 0.003).

Conclusion

LPL is related to a higher reoperation rate, more frequent postoperative ongoing sepsis, and higher recurrence rates. Therefore, laparoscopic lavage for perforated diverticulitis carries a high risk of failure in daily practice.
Literature
1.
go back to reference O'Sullivan GC, Murphy D, O'Brien MG, Ireland A (1996) Laparoscopic management of generalized peritonitis due to perforated colonic diverticula. Am J Surg 171(4):432–434CrossRefPubMed O'Sullivan GC, Murphy D, O'Brien MG, Ireland A (1996) Laparoscopic management of generalized peritonitis due to perforated colonic diverticula. Am J Surg 171(4):432–434CrossRefPubMed
2.
go back to reference Myers E, Hurley M, O'Sullivan GC, Kavanagh D, Wilson I, Winter DC (2008) Laparoscopic peritoneal lavage for generalized peritonitis due to perforated diverticulitis. Br J Surg 95(1):97–101CrossRefPubMed Myers E, Hurley M, O'Sullivan GC, Kavanagh D, Wilson I, Winter DC (2008) Laparoscopic peritoneal lavage for generalized peritonitis due to perforated diverticulitis. Br J Surg 95(1):97–101CrossRefPubMed
3.
go back to reference Sorrentino M, Brizzolari M, Scarpa E, Malisan D, Bruschi F, Bertozzi S, Bernardi S, Petri R (2015) Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a definitive treatment? Retrospective analysis of 63 cases. Tech Coloproctol 19(2):105–110CrossRefPubMed Sorrentino M, Brizzolari M, Scarpa E, Malisan D, Bruschi F, Bertozzi S, Bernardi S, Petri R (2015) Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a definitive treatment? Retrospective analysis of 63 cases. Tech Coloproctol 19(2):105–110CrossRefPubMed
4.
go back to reference Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, van Geloven A, Gerhards MF, Govaert MJ, van Grevenstein W, Hoofwijk AG, Kruyt PM, Nienhuijs SW, Boermeester MA, Vermeulen J, van Dieren S, Lange JF, Bemelman WA, Ladies trial colloborators (2015) Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 386(10000):1269–1277CrossRefPubMed Vennix S, Musters GD, Mulder IM, Swank HA, Consten EC, Belgers EH, van Geloven A, Gerhards MF, Govaert MJ, van Grevenstein W, Hoofwijk AG, Kruyt PM, Nienhuijs SW, Boermeester MA, Vermeulen J, van Dieren S, Lange JF, Bemelman WA, Ladies trial colloborators (2015) Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 386(10000):1269–1277CrossRefPubMed
5.
go back to reference Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Körner H, Dahl FA, Øresland T, SCANDIV Study Group (2015) Laparoscopic lavage vs primary resection for acute perforated diverticulitis: the SCANDIV randomized clinical trial. JAMA 314(13):1364–1375CrossRefPubMed Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Körner H, Dahl FA, Øresland T, SCANDIV Study Group (2015) Laparoscopic lavage vs primary resection for acute perforated diverticulitis: the SCANDIV randomized clinical trial. JAMA 314(13):1364–1375CrossRefPubMed
6.
go back to reference Angenete E, Thornell A, Burcharth J, Pommergaard HC, Skullman S, Bisgaard T, Jess P, Läckberg Z, Matthiessen P, Heath J, Rosenberg J, Haglind E (2016) Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 263(1):117–122CrossRefPubMed Angenete E, Thornell A, Burcharth J, Pommergaard HC, Skullman S, Bisgaard T, Jess P, Läckberg Z, Matthiessen P, Heath J, Rosenberg J, Haglind E (2016) Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 263(1):117–122CrossRefPubMed
7.
go back to reference Oberkofler CE, Rickenbacher A, Raptis DA et al (2012) A multicenter randomized clinical trial of primary anastomosis or Hartmann’s procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis. Ann Surg 256(5):819–826CrossRefPubMed Oberkofler CE, Rickenbacher A, Raptis DA et al (2012) A multicenter randomized clinical trial of primary anastomosis or Hartmann’s procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis. Ann Surg 256(5):819–826CrossRefPubMed
8.
go back to reference Abraha I, Binda GA, Montedori A, Arezzo A, Cirocchi R (2017) Laparoscopic versus open resection for sigmoid diverticulitis. Cochrane Database Syst Rev 11:Cd009277PubMed Abraha I, Binda GA, Montedori A, Arezzo A, Cirocchi R (2017) Laparoscopic versus open resection for sigmoid diverticulitis. Cochrane Database Syst Rev 11:Cd009277PubMed
9.
go back to reference Sartelli M, Catena F, Ansaloni L et al (2016) WSES guidelines for the management of acute left sided colonic diverticulitis in the emergency setting. World J Emerg Surg 11:37CrossRefPubMedPubMedCentral Sartelli M, Catena F, Ansaloni L et al (2016) WSES guidelines for the management of acute left sided colonic diverticulitis in the emergency setting. World J Emerg Surg 11:37CrossRefPubMedPubMedCentral
10.
go back to reference Feingold D, Steele SR, Lee S, Kaiser A, Boushey R, Buie WD, Rafferty JF (2014) Practice parameters for the treatment of sigmoid diverticulitis. Dis Colon Rectum 57:284–294CrossRefPubMed Feingold D, Steele SR, Lee S, Kaiser A, Boushey R, Buie WD, Rafferty JF (2014) Practice parameters for the treatment of sigmoid diverticulitis. Dis Colon Rectum 57:284–294CrossRefPubMed
11.
go back to reference Andeweg CS, Mulder IM, Felt-Bersma RJ, Verbon A, van der Wilt G, van Goor H, Lange JF, Stoker J, Boermeester MA, Bleichrodt RP, Netherlands Society of Surgery, Working group from Netherlands Societies of Internal Medicine, Gastroenterologists, Radiology, Health echnology Assessment and Dieticians (2013) Guidelines of diagnostics and treatment of acute left-sided colonic diverticulitis. Dig Surg 30:278–292CrossRefPubMed Andeweg CS, Mulder IM, Felt-Bersma RJ, Verbon A, van der Wilt G, van Goor H, Lange JF, Stoker J, Boermeester MA, Bleichrodt RP, Netherlands Society of Surgery, Working group from Netherlands Societies of Internal Medicine, Gastroenterologists, Radiology, Health echnology Assessment and Dieticians (2013) Guidelines of diagnostics and treatment of acute left-sided colonic diverticulitis. Dig Surg 30:278–292CrossRefPubMed
12.
go back to reference Wasvary H, Turfah F, Kadro O, Beauregard W (1999) Same hospitalization resection for acute diverticulitis. Am Surg 65(7):632–635PubMed Wasvary H, Turfah F, Kadro O, Beauregard W (1999) Same hospitalization resection for acute diverticulitis. Am Surg 65(7):632–635PubMed
13.
go back to reference Linder MM, Wacha H, Feldmann U, Wesch G, Streifensand RA, Gundlach E (1987) The Mannheim peritonitis index. An instrument for the intraoperative prognosis of peritonitis. Chirurg 58(2):84–92PubMed Linder MM, Wacha H, Feldmann U, Wesch G, Streifensand RA, Gundlach E (1987) The Mannheim peritonitis index. An instrument for the intraoperative prognosis of peritonitis. Chirurg 58(2):84–92PubMed
14.
go back to reference Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRefPubMedPubMedCentral
15.
go back to reference Cirocchi R, Trastulli S, Vettoretto N, Milani D, Cavaliere D, Renzi C, Adamenko O, Desiderio J, Burattini MF, Parisi A, Arezzo A, Fingerhut A (2015) Laparoscopic peritoneal lavage. Medicine 94(1):e334CrossRefPubMedPubMedCentral Cirocchi R, Trastulli S, Vettoretto N, Milani D, Cavaliere D, Renzi C, Adamenko O, Desiderio J, Burattini MF, Parisi A, Arezzo A, Fingerhut A (2015) Laparoscopic peritoneal lavage. Medicine 94(1):e334CrossRefPubMedPubMedCentral
16.
go back to reference Swank H, Mulder I, Hoofwijk A et al (2013) Early experience with laparoscopic lavage for perforated diverticulitis. Br J Surg 100(5):704–710CrossRefPubMed Swank H, Mulder I, Hoofwijk A et al (2013) Early experience with laparoscopic lavage for perforated diverticulitis. Br J Surg 100(5):704–710CrossRefPubMed
17.
go back to reference Binda G, Bonino M, Siri G et al (2018) Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study). Br J Surg 105(13):1835–1843CrossRefPubMed Binda G, Bonino M, Siri G et al (2018) Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study). Br J Surg 105(13):1835–1843CrossRefPubMed
18.
go back to reference Acuna S, Wood T, Chesney T, Dossa F, Wexner SD, Quereshy FA, Chadi SA, Baxter NN (2018) Operative strategies for perforated diverticulitis. Dis Colon rectum 61(12):1442–1453 Acuna S, Wood T, Chesney T, Dossa F, Wexner SD, Quereshy FA, Chadi SA, Baxter NN (2018) Operative strategies for perforated diverticulitis. Dis Colon rectum 61(12):1442–1453
19.
go back to reference Cirocchi R, Di Saverio S, Weber D et al (2017) Laparoscopic lavage versus surgical resection for acute diverticulitis with generalised peritonitis: a systematic review and meta-analysis. Tech Coloproctol 21(2):93–110CrossRefPubMed Cirocchi R, Di Saverio S, Weber D et al (2017) Laparoscopic lavage versus surgical resection for acute diverticulitis with generalised peritonitis: a systematic review and meta-analysis. Tech Coloproctol 21(2):93–110CrossRefPubMed
20.
go back to reference Angenete E, Bock D, Rosenberg J, Haglind E (2016) Laparoscopic lavage is superior to colon resection for perforated purulent diverticulitis—a meta-analysis. Int J Color Dis 32(2):163–169CrossRef Angenete E, Bock D, Rosenberg J, Haglind E (2016) Laparoscopic lavage is superior to colon resection for perforated purulent diverticulitis—a meta-analysis. Int J Color Dis 32(2):163–169CrossRef
21.
go back to reference Daher R, Barouki E, Chouillard E (2016) Laparoscopic treatment of complicated colonic diverticular disease: a review. World J Gastrointest Surg 8(2):134–142CrossRefPubMedPubMedCentral Daher R, Barouki E, Chouillard E (2016) Laparoscopic treatment of complicated colonic diverticular disease: a review. World J Gastrointest Surg 8(2):134–142CrossRefPubMedPubMedCentral
22.
go back to reference Galbraith N, Carter J, Netz U, Yang D, Fry DE, McCafferty M, Galandiuk S (2017) Laparoscopic lavage in the management of perforated diverticulitis: a contemporary meta-analysis. J Gastrointest Surg 21(9):1491–1499CrossRefPubMed Galbraith N, Carter J, Netz U, Yang D, Fry DE, McCafferty M, Galandiuk S (2017) Laparoscopic lavage in the management of perforated diverticulitis: a contemporary meta-analysis. J Gastrointest Surg 21(9):1491–1499CrossRefPubMed
23.
24.
go back to reference Marshall J, Buchwald P, Gandhi J, Schultz JK, Hider PN, Frizelle FA, Eglinton TW (2017) Laparoscopic lavage in the management of Hinchey grade III diverticulitis. Ann Surg 265(4):670–676CrossRefPubMed Marshall J, Buchwald P, Gandhi J, Schultz JK, Hider PN, Frizelle FA, Eglinton TW (2017) Laparoscopic lavage in the management of Hinchey grade III diverticulitis. Ann Surg 265(4):670–676CrossRefPubMed
25.
go back to reference Penna M, Markar S, Mackenzie H, Hompes R, Cunningham C (2018) Laparoscopic lavage versus primary resection for acute perforated diverticulitis. Ann Surg 267(2):252–258CrossRefPubMed Penna M, Markar S, Mackenzie H, Hompes R, Cunningham C (2018) Laparoscopic lavage versus primary resection for acute perforated diverticulitis. Ann Surg 267(2):252–258CrossRefPubMed
26.
go back to reference Shaikh F, Stewart P, Walsh SR, Davies RJ (2017) Laparoscopic peritoneal lavage or surgical resection for acute perforated sigmoid diverticulitis: a systematic review and meta-analysis. Int J Surg 38:130–137CrossRefPubMed Shaikh F, Stewart P, Walsh SR, Davies RJ (2017) Laparoscopic peritoneal lavage or surgical resection for acute perforated sigmoid diverticulitis: a systematic review and meta-analysis. Int J Surg 38:130–137CrossRefPubMed
27.
go back to reference Catry J, Brouquet A, Peschaud F et al (2016) Sigmoid resection with primary anastomosis and ileostomy versus laparoscopic lavage in purulent peritonitis from perforated diverticulitis: outcome analysis in a prospective cohort of 40 consecutive patients. Int J Color Dis 31(10):1693–1699CrossRef Catry J, Brouquet A, Peschaud F et al (2016) Sigmoid resection with primary anastomosis and ileostomy versus laparoscopic lavage in purulent peritonitis from perforated diverticulitis: outcome analysis in a prospective cohort of 40 consecutive patients. Int J Color Dis 31(10):1693–1699CrossRef
28.
go back to reference Schultz J, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Kørner H, Dahl FA, Øresland T, Yaqub S, SCANDIV Study Group (2017) One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis. Br J Surg 104(10):1382–1392CrossRefPubMed Schultz J, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Kørner H, Dahl FA, Øresland T, Yaqub S, SCANDIV Study Group (2017) One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis. Br J Surg 104(10):1382–1392CrossRefPubMed
29.
go back to reference Desai G, Narkhede R, Pande P, Bhole B, Varty P, Mehta H (2018) An outcome analysis of laparoscopic management of diverticulitis. Indian J Gastroenterol 37(5):430–438CrossRefPubMed Desai G, Narkhede R, Pande P, Bhole B, Varty P, Mehta H (2018) An outcome analysis of laparoscopic management of diverticulitis. Indian J Gastroenterol 37(5):430–438CrossRefPubMed
30.
go back to reference Binda GA, Karas JR, Serventi A et al (2012) Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. Color Dis 14(11):1403–1410CrossRef Binda GA, Karas JR, Serventi A et al (2012) Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. Color Dis 14(11):1403–1410CrossRef
31.
go back to reference Bridoux V, Regimbeau J, Ouaissi M, Mathonnet M, Mauvais F, Houivet E, Schwarz L, Mege D, Sielezneff I, Sabbagh C, Tuech JJ (2017) Hartmann's procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 225(6):798–805CrossRefPubMed Bridoux V, Regimbeau J, Ouaissi M, Mathonnet M, Mauvais F, Houivet E, Schwarz L, Mege D, Sielezneff I, Sabbagh C, Tuech JJ (2017) Hartmann's procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 225(6):798–805CrossRefPubMed
32.
go back to reference Acuna S, Wood T, Chesney T, Dossa F, Wexner SD, Quereshy FA, Chadi SA, Baxter NN (2018) Operative strategies for perforated diverticulitis. Dis Colon Rectum 61(12):1442–1453PubMed Acuna S, Wood T, Chesney T, Dossa F, Wexner SD, Quereshy FA, Chadi SA, Baxter NN (2018) Operative strategies for perforated diverticulitis. Dis Colon Rectum 61(12):1442–1453PubMed
33.
go back to reference Timmermans L, Deerenberg E et al (2014) Parastomal hernia is an independent risk factor for incisional hernia in patients with end colostomy. Surgery 155(1):178–183CrossRefPubMed Timmermans L, Deerenberg E et al (2014) Parastomal hernia is an independent risk factor for incisional hernia in patients with end colostomy. Surgery 155(1):178–183CrossRefPubMed
Metadata
Title
Laparoscopic peritoneal lavage versus laparoscopic sigmoidectomy in complicated acute diverticulitis: a multicenter prospective observational study
Authors
Dario Tartaglia
Salomone Di Saverio
Weronika Stupalkowska
Sandro Giannessi
Virna Robustelli
Federico Coccolini
Orestis Ioannidis
Gabriela Elisa Nita
Virginia María Durán Muñoz-Cruzado
Felipe Pareja Ciuró
Massimo Chiarugi
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 12/2019
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-019-03429-5

Other articles of this Issue 12/2019

International Journal of Colorectal Disease 12/2019 Go to the issue