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01-03-2014 | Original Article

Enhancement of phototoxicity of curcumin in human oral cancer cells using silica nanoparticles as delivery vehicle

Authors: Surya Prakash Singh, Mrinalini Sharma, Pradeep Kumar Gupta

Published in: Lasers in Medical Science | Issue 2/2014

Abstract

We report results on the use of organically modified silica nanoparticles (SiNp) as a vehicle for the delivery of curcumin in human oral cancer cells for improvement of uptake and phototoxicity. Nanoformulated drug (curcumin–SiNp complex) was prepared by postloading curcumin in SiNp, and the complex was soluble in aqueous solution. Cellular uptake studied by fluorescence microscopy and spectroscopy showed that curcumin accumulation was higher when cells were incubated with curcumin–SiNp complex as against free curcumin. Studies carried out on incubation time-dependent cytotoxicity, inhibition of NF-κB activity, suppression of NF-κB-regulated proteins involved in invasion (MMP-9), angiogenesis (VEGF), and inflammation (TNF-α) showed that curcumin–SiNp leads to significant improvement over free curcumin in dark as well as on exposure to light.

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Title: Enhancement of phototoxicity of curcumin in human oral cancer cells using silica nanoparticles as delivery vehicle
Authors: Surya Prakash Singh
Mrinalini Sharma
Pradeep Kumar Gupta
Publication date: 01-03-2014
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 2/2014
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-013-1357-7

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Enhancement of phototoxicity of curcumin in human oral cancer cells using silica nanoparticles as delivery vehicle

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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