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Journal of Cardiovascular Translational Research

Published in:

01-08-2012

Enhanced Endothelialization of a New Stent Polymer Through Surface Enhancement and Incorporation of Growth Factor-Delivering Microparticles

Authors: Hao Xu, Kytai T. Nguyen, Emmanouil S. Brilakis, Jian Yang, Eric Fuh, Subhash Banerjee

Published in: Journal of Cardiovascular Translational Research | Issue 4/2012

Abstract

In this study, we sought to develop strategies for improved endothelialization of a new polymer coating for vascular stents. Surface enhancement of the new poly-1,8-octanediol-co-citric acid (POC) polymer was achieved through conjugation of anti-CD34 antibody and incorporation of vascular endothelial growth factor and basic fibroblast growth factor-containing poly-lactic-co-glycolic acid microparticles to improve capture and proliferation of endothelial progenitor cells (EPC) and compared to untreated POC and poly-L-lactic acid (PLLA) polymer. Our results indicate that compared to PLLA, POC coating was more hemocompatible, with less platelet activation (p = 0.01), thrombogenicity (p < 0.05 for 20 and 30 min clot formation), and inflammatory response (IL-1β release, p = 0.0009; TNF-α release, p = 0.004). EPC adhesion and proliferation on POC were significantly improved with surface enhancement and microparticle incorporation compared to untreated POC (p = 0.006) and PLLA (p = 0.003). These results suggest a new strategy for enhancing endothelialization of polymeric coatings of vascular prostheses.

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Title: Enhanced Endothelialization of a New Stent Polymer Through Surface Enhancement and Incorporation of Growth Factor-Delivering Microparticles
Authors: Hao Xu
Kytai T. Nguyen
Emmanouil S. Brilakis
Jian Yang
Eric Fuh
Subhash Banerjee
Publication date: 01-08-2012
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 4/2012
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-012-9381-8

2024 ASCO Annual Meeting

Springer Medicine

Enhanced Endothelialization of a New Stent Polymer Through Surface Enhancement and Incorporation of Growth Factor-Delivering Microparticles

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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