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BMC Surgery
Published in: BMC Surgery 1/2024

Open Access 01-12-2024 | Bariatric Surgery | Research

Energy expenditure related biomarkers following bariatric surgery: a prospective six-month cohort study

Authors: Mahsa Hatami, Mohammad Hassan Javanbakht, Neda Haghighat, Zahra Sohrabi, Rahman Yavar, Abdolreza Pazouki, Gholamreza Mohammadi Farsani

Published in: BMC Surgery | Issue 1/2024

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Abstract

Background

Mitochondria dysfunction is one of the major causes of insulin resistance, and other countless complications of obesity. PGC-1α, and UCP-2 play key roles in energy expenditure regulation in the mitochondrial thermogenesis. However, the effects of bariatric surgery on the level of PGC-1α and UCP-2 and their relationships are unclear.

Objective

This study aimed to investigate the effect of bariatric surgery on key pathways in energy, and to assess the potential predictive role of body composition and metabolic parameters in this regard.

Settings

Hazrat-e Rasool General Hospital, Center of Excellence of International Federation for Surgery of Obesity.

Methods

This prospective cohort study was carried out on 45 patients with morbid obesity who underwent Roux-en-Y gastric bypass surgery. The patients have evaluated three-time points at baseline, three, and six months after the surgery. Body composition components, the levels of PGC-1α, UCP-2, and metabolic parameters were measured three times during this study.

Results

Significant changes in TWL%, EBMIL%, and metabolic lab tests were observed at three- and six months post-surgery (P < 0.001). The PGC-1α and UCP-2 had a significant increase three and then six-month post-operation compared with the baseline (P < 0.001). Moreover, multivariate linear regression analysis identified that the changing trend of PGC-1α was associated with insulin, uric Acid, HOMA-IR, fat mass and trunk fat mass. UCP-2 was associated with TSH, AST, fat mass and FFM.

Conclusions

Bariatric surgery has been shown to have a positive effect on UCP-2 and PGC-1α levels, as well as body composition and metabolic parameters. As a result, it is believed that bariatric surgery could improve thermogenesis and energy expenditure by enhancing mitochondrial biogenesis and function. However, further studies are needed to fully understand the precise mechanisms and possible causal relationship.
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Metadata
Title
Energy expenditure related biomarkers following bariatric surgery: a prospective six-month cohort study
Authors
Mahsa Hatami
Mohammad Hassan Javanbakht
Neda Haghighat
Zahra Sohrabi
Rahman Yavar
Abdolreza Pazouki
Gholamreza Mohammadi Farsani
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2024
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-024-02421-3

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