Published in:
01-02-2015 | Editorial
Energy deficit is clinically relevant for critically ill patients: no
Authors:
L. John Hoffer, Bruce R. Bistrian
Published in:
Intensive Care Medicine
|
Issue 2/2015
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Excerpt
Clinical trials should be based on solid science. Unfortunately, many recent randomized clinical trials (RCTs) of nutritional support in critical illness have fallen short of this standard by focusing solely on the benefits of high calorie provision, while ignoring a much more important nutritional requirement in this setting [
1,
2]. In particular, the amount of protein provided in all but two recent clinical trials—both of which indicated better outcomes in the protein-supplemented patients [
3,
4]—was drastically less than what the best available evidence indicates it ought to be [
5‐
9]. …