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Journal of Interventional Cardiac Electrophysiology

Published in:

01-04-2008

Endothelin system and atrial fibrillation post-cardiac surgery

Authors: Theofilos M. Kolettis, Zenon S. Kyriakides, Eleni Zygalaki, Stamatis Kyrzopoulos, Loukas Kaklamanis, Nikolaos Nikolaou, Evi S. Lianidou, Dimitrios Th. Kremastinos

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 3/2008

Abstract

Objective

We investigated the relation between the endothelin system and atrial fibrillation.

Background

Endothelin has been implicated in the pathophysiology of atrial fibrillation, but the exact role of A- and B-receptors is unknown.

Methods

We obtained right atrial biopsies from patients in sinus rhythm and preserved left ventricular function, undergoing off-pump coronary artery bypass grafting. The expression of endothelin, A- and B-receptors was measured using real time reverse-transcribed polymerase chain reaction.

Results

We studied 52 patients (45 male, mean age 66 ± 1 years, mean ejection fraction 52 ± 1%). During a 5-day post-operative period, persistent atrial fibrillation occurred in 15 patients (28.8%). Endothelin mRNA expression was comparable in patients who subsequently developed atrial fibrillation and in those maintaining sinus rhythm. However, the former group displayed down-regulation of endothelin A- (by approximately 60%, p = 0.0059) and of B-receptors (by approximately 40%, p = 0.0084). The decreased endothelin A-receptor expression could predict atrial fibrillation occurrence (Wilks λ = 0.86, F = 6.16, p = 0.017).

Conclusion

Decreased endothelin A- and B-receptor expression is associated with atrial fibrillation after bypass surgery.

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Title: Endothelin system and atrial fibrillation post-cardiac surgery
Authors: Theofilos M. Kolettis
Zenon S. Kyriakides
Eleni Zygalaki
Stamatis Kyrzopoulos
Loukas Kaklamanis
Nikolaos Nikolaou
Evi S. Lianidou
Dimitrios Th. Kremastinos
Publication date: 01-04-2008
Publisher: Springer US
Published in: Journal of Interventional Cardiac Electrophysiology / Issue 3/2008
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-008-9206-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Endothelin system and atrial fibrillation post-cardiac surgery

Abstract

Objective

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Background

Methods

Results

Conclusion

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