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01-11-2016 | Dynamic Manuscript

Endoscopic submucosal dissection with the Nestis^® jet injector system with a bifunctional catheter: first prospective clinical trial (NCT: 2012-A00272-41)

Authors: Mathieu Pioche, Vincent Lépilliez, Mihai Ciocîrlan, Jérôme Rivory, Clothilde Miaglia, Valérie Hervieu, Gilles Poncet, Pierre-Jean Valette, Jean-Christophe Saurin, Thierry Ponchon

Published in: Surgical Endoscopy | Issue 11/2016

Abstract

Background

The Enki-2 water jet system (Nestis SAS^®, Lyon, France) with dual injection and dissection capability significantly reduced ESD procedure time and perforation rates in animal studies. The study aim was to evaluate its efficacy and safety in patients with superficial neoplastic lesions.

Methods

A prospective study including 18 patients with esophageal, gastric and rectal superficial neoplasms treated by ESD using Enki-2 was designed.

Results

Eighteen lesions (6 esophageal, 3 gastric, 9 rectal, mean diameter 43.5 mm) in 17 patients (10 men, mean age 65.9) were included. The mean procedure time was 65.6 min. One patient needed clipping for an incomplete muscle tear during procedure; there were neither delayed bleedings nor perforation. The “en bloc” resection rate was 100 %, the R0 resection rate was 88.9 % (16/18 lesions), and the curative resection rate was 77.8 %. The 3-month disease-free rate was 92.3 % (12/13 patients, 13/14 lesions, 1 patient lost to follow-up). The 12-month disease-free rate was 69.2 % (9/13 patients, 10/14 lesions, 4 patients lost to follow-up).

Conclusions

ESD with Enki-2 water jet system is effective and safe for superficial neoplastic digestive lesions.

Available only for authorised users

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Title: Endoscopic submucosal dissection with the Nestis® jet injector system with a bifunctional catheter: first prospective clinical trial (NCT: 2012-A00272-41)
Authors: Mathieu Pioche
Vincent Lépilliez
Mihai Ciocîrlan
Jérôme Rivory
Clothilde Miaglia
Valérie Hervieu
Gilles Poncet
Pierre-Jean Valette
Jean-Christophe Saurin
Thierry Ponchon
Publication date: 01-11-2016
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 11/2016
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-016-4827-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Endoscopic submucosal dissection with the Nestis^® jet injector system with a bifunctional catheter: first prospective clinical trial (NCT: 2012-A00272-41)

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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