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Published in: Surgical Endoscopy 5/2010

01-05-2010

Endoscopic management of pancreatic pseudocysts at atypical locations

Authors: Deepak Kumar Bhasin, Surinder Singh Rana, Mohit Nanda, Vijant Singh Chandail, Ibrahim Masoodi, Mandeep Kang, Navin Kalra, Saroj Kant Sinha, Birinder Nagi, Kartar Singh

Published in: Surgical Endoscopy | Issue 5/2010

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Abstract

Background and aims

There is paucity of data on endoscopic management of pseudocysts at atypical locations. We evaluated the efficacy of endoscopic transpapillary nasopancreatic drain (NPD) placement in the management of pseudocysts of pancreas at atypical locations.

Patients and methods

Eleven patients with pseudocysts at atypical locations were treated with attempted endoscopic transpapillary nasopancreatic drainage. On endoscopic retrograde pancreatography (ERP), a 5-F NPD was placed across/near the site of duct disruption.

Results

Three patients each had mediastinal, intrahepatic, and intra/perisplenic pseudocysts and one patient each had renal and pelvic pseudocyst. Nine patients had chronic pancreatitis whereas two patients had acute pancreatitis. The size of the pseudocysts ranged from 2 to 15 cm. On ERP, the site of ductal disruption was in the body of pancreas in five patients (45.4%), and tail of pancreas in six patients (54.6%). All the patients had partial disruption of pancreatic duct. The NPD was successfully placed across the disruption in 10 of the 11 patients (90.9%) and pseudocysts resolved in 4–8 weeks. One of the patients developed fever, 5 days after the procedure, which was successfully treated by intravenous antibiotics. In another patient, NPD became blocked 12 days after the procedure and was successfully opened by aspiration. The NPD slipped out in one of the patient with splenic pseudocyst and was replaced with a stent. There was no recurrence of symptoms or pseudocysts during follow-up of 3–70 months.

Conclusion

Pancreatic pseudocysts at atypical locations with ductal communication and partial ductal disruption that is bridged by NPD can also be effectively treated with endoscopic transpapillary NPD placement.
Literature
2.
go back to reference Bhasin DK, Rana SS, Chandail V, Nanda M, Nadkarni N, Sinha SK, Nagi B (2005) Intrahepatic pancreatic pseudocyst successfully treated by endoscopic transpapillary nasopancreatic drainage alone. JOP (online) 6:593–597 Bhasin DK, Rana SS, Chandail V, Nanda M, Nadkarni N, Sinha SK, Nagi B (2005) Intrahepatic pancreatic pseudocyst successfully treated by endoscopic transpapillary nasopancreatic drainage alone. JOP (online) 6:593–597
3.
go back to reference Bhasin DK, Rana SS, Chandail VS, Nanda M, Sinha SK, Nagi B (2005) Successful resolution of a mediastinal pseudocyst and pancreatic pleural effusion by endoscopic nasopancreatic drainage. JOP (online) 6:359–364 Bhasin DK, Rana SS, Chandail VS, Nanda M, Sinha SK, Nagi B (2005) Successful resolution of a mediastinal pseudocyst and pancreatic pleural effusion by endoscopic nasopancreatic drainage. JOP (online) 6:359–364
4.
go back to reference Bhasin DK, Udawat HP, Rana SS, Sood AK, Sinha SK, Nagi B (2005) Intra-splenic pancreatic abscess successfully treated by endoscopic transpapillary drainage through the minor papilla. Gastrointest Endosc 62:192–194CrossRefPubMed Bhasin DK, Udawat HP, Rana SS, Sood AK, Sinha SK, Nagi B (2005) Intra-splenic pancreatic abscess successfully treated by endoscopic transpapillary drainage through the minor papilla. Gastrointest Endosc 62:192–194CrossRefPubMed
5.
go back to reference Gandhi M, Barone JG (2006) Pediatric renal pseudocyst due to pancreatitis. Urology 68:1344 e5–1344 e6CrossRef Gandhi M, Barone JG (2006) Pediatric renal pseudocyst due to pancreatitis. Urology 68:1344 e5–1344 e6CrossRef
6.
go back to reference Topa L, László F, Sahin P, Pozsár J (2006) Endoscopic transgastric drainage of a pancreatic pseudocyst with mediastinal and cervical extensions. Gastrointest Endosc 64:460–463CrossRefPubMed Topa L, László F, Sahin P, Pozsár J (2006) Endoscopic transgastric drainage of a pancreatic pseudocyst with mediastinal and cervical extensions. Gastrointest Endosc 64:460–463CrossRefPubMed
7.
go back to reference Balzan S, Kianmanesh R, Farges O, Sauvanet A, O’toole D, Levy P, Ruszniewski P, Ogata S, Belghiti J (2005) Right intrahepatic pseudocyst following acute pancreatitis: an unusual location after acute pancreatitis. J Hepatobiliary Pancreat Surg 12:135–137CrossRefPubMed Balzan S, Kianmanesh R, Farges O, Sauvanet A, O’toole D, Levy P, Ruszniewski P, Ogata S, Belghiti J (2005) Right intrahepatic pseudocyst following acute pancreatitis: an unusual location after acute pancreatitis. J Hepatobiliary Pancreat Surg 12:135–137CrossRefPubMed
8.
go back to reference Gupta R, Munoz JC, Garg P, Masri G, Nahman NS Jr, Lambiase LR (2007) Mediastinal pancreatic pseudocyst–a case report and review of the literature. MedGenMed 9:8PubMed Gupta R, Munoz JC, Garg P, Masri G, Nahman NS Jr, Lambiase LR (2007) Mediastinal pancreatic pseudocyst–a case report and review of the literature. MedGenMed 9:8PubMed
9.
go back to reference Shenoy P, Ganesan P, Swaminathan RP (2007) Systemic hypertension due to compression of the kidney by a pancreatic pseudocyst. Eur J Intern Med 18:507–508CrossRefPubMed Shenoy P, Ganesan P, Swaminathan RP (2007) Systemic hypertension due to compression of the kidney by a pancreatic pseudocyst. Eur J Intern Med 18:507–508CrossRefPubMed
10.
go back to reference Mofredj A, Cadranel JF, Dautreaux M, Kazerouni F, Hadj-Nacer K, Deplaix P, Francois G, Danon O, Lukumbo S, Collot G, Levy P, Harry G (2000) Pancreatic pseudocyst located in the liver: a case report and literature review. J Clin Gastroenterol 30:81–83CrossRefPubMed Mofredj A, Cadranel JF, Dautreaux M, Kazerouni F, Hadj-Nacer K, Deplaix P, Francois G, Danon O, Lukumbo S, Collot G, Levy P, Harry G (2000) Pancreatic pseudocyst located in the liver: a case report and literature review. J Clin Gastroenterol 30:81–83CrossRefPubMed
11.
go back to reference Johnson RH Jr, Owensby LC, Vargas GM, Garcia-Rinaldi R (1986) Pancreatic pseudocyst of the mediastinum. Ann Thorac Surg 41:210–212 Johnson RH Jr, Owensby LC, Vargas GM, Garcia-Rinaldi R (1986) Pancreatic pseudocyst of the mediastinum. Ann Thorac Surg 41:210–212
12.
go back to reference Lo J, Tang S (1995) CT of multiple subcapsular pseudocysts of the kidney complicating acute pancreatitis. J Comput Assist Tomogr 19:823–824CrossRefPubMed Lo J, Tang S (1995) CT of multiple subcapsular pseudocysts of the kidney complicating acute pancreatitis. J Comput Assist Tomogr 19:823–824CrossRefPubMed
14.
go back to reference Kozarek RA, Brayko CM, Harlan J, Sanowski RA, Cintora I, Kovac A (1985) Endoscopic drainage of pancreatic pseudocysts. Gastrointest Endosc 31:322–327CrossRefPubMed Kozarek RA, Brayko CM, Harlan J, Sanowski RA, Cintora I, Kovac A (1985) Endoscopic drainage of pancreatic pseudocysts. Gastrointest Endosc 31:322–327CrossRefPubMed
15.
go back to reference Kozarek RA, Ball TJ, Patterson DJ, Freeny PC, Ryan JA, Traverso LW (1991) Endoscopic transpapillary therapy for disrupted pancreatic duct and peripancreatic fluid collections. Gastroenterology 100:1362–1370PubMed Kozarek RA, Ball TJ, Patterson DJ, Freeny PC, Ryan JA, Traverso LW (1991) Endoscopic transpapillary therapy for disrupted pancreatic duct and peripancreatic fluid collections. Gastroenterology 100:1362–1370PubMed
16.
go back to reference Telford JJ, Farrell JJ, Saltzman JR, Shields SJ, Banks PA, Lichtenstein DR, Johannes RS, Kelsey PB, Carr-Locke DL (2002) Pancreatic stent placement for duct disruption. Gastrointest Endosc 56:18–24CrossRefPubMed Telford JJ, Farrell JJ, Saltzman JR, Shields SJ, Banks PA, Lichtenstein DR, Johannes RS, Kelsey PB, Carr-Locke DL (2002) Pancreatic stent placement for duct disruption. Gastrointest Endosc 56:18–24CrossRefPubMed
17.
go back to reference Bhasin DK, Dhavan S, Sriram PV, Nagi B, Varma V, Singh G, Behra A, Singh K (1997) Endoscopic management of pancreatic diseases. Ind J Gastroenterol 16:151–152 Bhasin DK, Dhavan S, Sriram PV, Nagi B, Varma V, Singh G, Behra A, Singh K (1997) Endoscopic management of pancreatic diseases. Ind J Gastroenterol 16:151–152
18.
go back to reference Giovannini M (2007) What is the best endoscopic treatment for pancreatic pseudocysts? Gastrointest Endosc 65:620–623CrossRefPubMed Giovannini M (2007) What is the best endoscopic treatment for pancreatic pseudocysts? Gastrointest Endosc 65:620–623CrossRefPubMed
19.
go back to reference Delhaye M, Matos C, Deviere J (2003) Endoscopic management of chronic pancreatitis. Gastrointest Endoscopy Clin North Am 13:717–742CrossRef Delhaye M, Matos C, Deviere J (2003) Endoscopic management of chronic pancreatitis. Gastrointest Endoscopy Clin North Am 13:717–742CrossRef
20.
go back to reference Bhasin DK, Rana SS, Udawat HP, Thapa BR, Sinha SK, Nagi B (2006) Management of multiple and large pseudocysts by endoscopic transpapillary nasopancreatic drainage alone. Am J Gastroenterol 101:1780–1786CrossRefPubMed Bhasin DK, Rana SS, Udawat HP, Thapa BR, Sinha SK, Nagi B (2006) Management of multiple and large pseudocysts by endoscopic transpapillary nasopancreatic drainage alone. Am J Gastroenterol 101:1780–1786CrossRefPubMed
21.
go back to reference Mohl W, Moser C, Kramann B, Zeuzem S, Stallmach A (2004) Endoscopic transhiatal drainage of a mediastinal pancreatic pseudocyst. Endoscopy 36:467CrossRefPubMed Mohl W, Moser C, Kramann B, Zeuzem S, Stallmach A (2004) Endoscopic transhiatal drainage of a mediastinal pancreatic pseudocyst. Endoscopy 36:467CrossRefPubMed
22.
go back to reference Bhasin DK, Rana SS, Chandail VS, Masoodi I, Nanda M, Nadkarni N, Sinha SK, Nagi B (2007) Secondary gastric volvulus following successful resolution of a large perisplenic pseudocyst by endoscopic transpapillary nasopancreatic drainage. Gastrointest Endosc 65:940–942CrossRefPubMed Bhasin DK, Rana SS, Chandail VS, Masoodi I, Nanda M, Nadkarni N, Sinha SK, Nagi B (2007) Secondary gastric volvulus following successful resolution of a large perisplenic pseudocyst by endoscopic transpapillary nasopancreatic drainage. Gastrointest Endosc 65:940–942CrossRefPubMed
23.
go back to reference Ammann R, Münch R, Largiader F, Akovbiantz A, Marincek B (1992) Pancreatic and hepatic abscesses: a late complication in 10 patients with chronic pancreatitis. Gastroenterology 103:560–565PubMed Ammann R, Münch R, Largiader F, Akovbiantz A, Marincek B (1992) Pancreatic and hepatic abscesses: a late complication in 10 patients with chronic pancreatitis. Gastroenterology 103:560–565PubMed
24.
go back to reference Shibasaki M, Bandai Y, Ukai T (2002) Pancreatic pseudocyst extending into the liver via the hepatoduodenal ligament: a case report. Hepatogastroenterology 49:1719–1721PubMed Shibasaki M, Bandai Y, Ukai T (2002) Pancreatic pseudocyst extending into the liver via the hepatoduodenal ligament: a case report. Hepatogastroenterology 49:1719–1721PubMed
25.
go back to reference Malka D, Hammel P, Levy P, Sauvanet A, Ruszniewski P, Belghiti J, Bernades P (1998) Splenic complications in chronic pancreatitis: prevalence and risk factors in a medical-surgical series of 500 patients. Br J Surg 85:1645–1649CrossRefPubMed Malka D, Hammel P, Levy P, Sauvanet A, Ruszniewski P, Belghiti J, Bernades P (1998) Splenic complications in chronic pancreatitis: prevalence and risk factors in a medical-surgical series of 500 patients. Br J Surg 85:1645–1649CrossRefPubMed
26.
go back to reference Sitzmann JV, Imbembo AL (1984) Splenic complications of a pancreatic pseudocyst. Am J Surg 147:191–196CrossRefPubMed Sitzmann JV, Imbembo AL (1984) Splenic complications of a pancreatic pseudocyst. Am J Surg 147:191–196CrossRefPubMed
27.
go back to reference Ueda N, Takahashi N, Yamasaki H, Hirano K, Ueda K, Yoshida S, Tanino M, Gabata T (1992) Intrasplenic pancreatic pseudocyst: a case report. Gastroenterol Jpn 27:675–682PubMed Ueda N, Takahashi N, Yamasaki H, Hirano K, Ueda K, Yoshida S, Tanino M, Gabata T (1992) Intrasplenic pancreatic pseudocyst: a case report. Gastroenterol Jpn 27:675–682PubMed
28.
go back to reference Quinn SF, van Sonnenberg E, Casola G, Wittich GR, Neff CC (1989) Interventional radiology in the spleen. Radiology 161:289–291 Quinn SF, van Sonnenberg E, Casola G, Wittich GR, Neff CC (1989) Interventional radiology in the spleen. Radiology 161:289–291
29.
go back to reference Tennoe B, Bay D, Rosales R (1996) Percutaneous drainage of intrasplenic pancreatic pseudocyst: case report. Acta Radiol 37:195–197PubMed Tennoe B, Bay D, Rosales R (1996) Percutaneous drainage of intrasplenic pancreatic pseudocyst: case report. Acta Radiol 37:195–197PubMed
30.
go back to reference Johnson RH Jr, Owensby LC, Vargas GM, Garcia-Rinaldi R (1986) Pancreatic pseudocyst of the mediastinum. Ann Thorac Surg 41:210–212CrossRef Johnson RH Jr, Owensby LC, Vargas GM, Garcia-Rinaldi R (1986) Pancreatic pseudocyst of the mediastinum. Ann Thorac Surg 41:210–212CrossRef
31.
go back to reference Mallavarapu R, Habib TH, Elton E, Goldberg MJ (2001) Resolution of mediastinal pancreatic pseudocysts with transpapillary stent placement. Gastrointest Endosc 53:367–370PubMed Mallavarapu R, Habib TH, Elton E, Goldberg MJ (2001) Resolution of mediastinal pancreatic pseudocysts with transpapillary stent placement. Gastrointest Endosc 53:367–370PubMed
32.
go back to reference Musana KA, Yale SH, Abdulkarim A, Rall CJ (2004) Successful endoscopic treatment of mediastinal pseudocysts. Clin Med Res 2:119–123CrossRefPubMed Musana KA, Yale SH, Abdulkarim A, Rall CJ (2004) Successful endoscopic treatment of mediastinal pseudocysts. Clin Med Res 2:119–123CrossRefPubMed
33.
go back to reference Kim DJ, Chung HW, Gham CW, Na HG, Park SW, Lee SJ, Chung JP, Song SY, Chung JB, Kang JK (2003) A case of complete resolution of mediastinal pseudocyst and pleural effusion by endoscopic stenting of pancreatic duct. Yonsei Med J 44:727–731PubMed Kim DJ, Chung HW, Gham CW, Na HG, Park SW, Lee SJ, Chung JP, Song SY, Chung JB, Kang JK (2003) A case of complete resolution of mediastinal pseudocyst and pleural effusion by endoscopic stenting of pancreatic duct. Yonsei Med J 44:727–731PubMed
34.
go back to reference Komtong S, Chanatrirattanapan R, Kongkam P, Rerknimitr R, Kullavanijaya P (2006) Mediastinal pseudocyst with pericardial effusion and dysphagia treated by endoscopic drainage. JOP 7:405–410PubMed Komtong S, Chanatrirattanapan R, Kongkam P, Rerknimitr R, Kullavanijaya P (2006) Mediastinal pseudocyst with pericardial effusion and dysphagia treated by endoscopic drainage. JOP 7:405–410PubMed
35.
go back to reference Saftoiu A, Ciurea T, Dumitrescu D, Stoica Z (2006) Endoscopic ultrasound-guided transesophageal drainage of a mediastinal pancreatic pseudocyst. Endoscopy 38:538–539CrossRefPubMed Saftoiu A, Ciurea T, Dumitrescu D, Stoica Z (2006) Endoscopic ultrasound-guided transesophageal drainage of a mediastinal pancreatic pseudocyst. Endoscopy 38:538–539CrossRefPubMed
36.
go back to reference Varadarajulu S, Noone TC, Tutuian R, Hawes RH, Cotton PB (2005) Predictors of outcome in pancreatic duct disruption managed by endoscopic transpapillary stent placement. Gastrointest Endosc 61:568–575CrossRefPubMed Varadarajulu S, Noone TC, Tutuian R, Hawes RH, Cotton PB (2005) Predictors of outcome in pancreatic duct disruption managed by endoscopic transpapillary stent placement. Gastrointest Endosc 61:568–575CrossRefPubMed
37.
go back to reference Kozarek RA (1990) Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc 36:93–95CrossRefPubMed Kozarek RA (1990) Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc 36:93–95CrossRefPubMed
38.
go back to reference Sherman S, Hawes RH, Savides TJ, Gress FG, Ikenberry SO, Smith MT, Zaidi S, Lehman GA (1996) Stent induced pancreatic ductal and parenchymal changes: correlation of endoscopic ultrasound with ERCP. Gastrointest Endosc 44:276–282CrossRefPubMed Sherman S, Hawes RH, Savides TJ, Gress FG, Ikenberry SO, Smith MT, Zaidi S, Lehman GA (1996) Stent induced pancreatic ductal and parenchymal changes: correlation of endoscopic ultrasound with ERCP. Gastrointest Endosc 44:276–282CrossRefPubMed
39.
go back to reference Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA (1996) Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc 44:268–275CrossRefPubMed Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA (1996) Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc 44:268–275CrossRefPubMed
40.
go back to reference Bhasin DK, Rana SS, Nadkarni N (2008) Protocol based management of post ERCP pancreatitis: Can it make the difference? J Gastroenterol Hepatol 23:344–347CrossRefPubMed Bhasin DK, Rana SS, Nadkarni N (2008) Protocol based management of post ERCP pancreatitis: Can it make the difference? J Gastroenterol Hepatol 23:344–347CrossRefPubMed
Metadata
Title
Endoscopic management of pancreatic pseudocysts at atypical locations
Authors
Deepak Kumar Bhasin
Surinder Singh Rana
Mohit Nanda
Vijant Singh Chandail
Ibrahim Masoodi
Mandeep Kang
Navin Kalra
Saroj Kant Sinha
Birinder Nagi
Kartar Singh
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 5/2010
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-009-0732-8

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