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Published in: Journal of Gastrointestinal Surgery 1/2011

01-01-2011 | Original Article

Endoscopic Intraoperative Anastomotic Testing May Avoid Early Gastrointestinal Anastomotic Complications. A Prospective Study

Authors: Eva Lieto, Michele Orditura, Paolo Castellano, Margherita Pinto, Anna Zamboli, Ferdinando De Vita, Carlo Pignatelli, Gennaro Galizia

Published in: Journal of Gastrointestinal Surgery | Issue 1/2011

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Abstract

Background

Gastrointestinal anastomotic complications represent serious events; methods to evaluate anastomotic integrity seem to be suboptimal. Since endoscopic intraoperative anastomotic testing allows direct visualization of anastomosis, complication rates may be theoretically reduced by the use of this technique.

Methods

A prospective study involving 118 consecutive oncologic patients undergoing endoscopically tested gastrointestinal stapled anastomoses was carried out. As controls, 148 historical patients without anastomotic testing were used for comparisons.

Results

In the study group, anastomotic testing revealed 16 defects: 11 (9.3%) air leaks and five (4.3%) bleeding anastomoses. All leaks were oversewn and secured. Bleeding anastomoses were managed under direct visualization, and one non-patent anastomosis was redone. Forty-one (15.4%) postoperative anastomotic complications were observed: eight (3%) bleeding anastomoses, seven (2.6%) stenoses, and 26 (9.8%) clinical leaks. No early dehiscence or bleeding occurred if anastomoses were intraoperatively checked, while these complications were significantly more frequent in non-checked anastomoses (6.1% and 5.4%, respectively). Conversely, late leak and stenosis rates were similar between the two groups.

Conclusion

Endoscopic anastomotic testing was a safe and reliable method to assess integrity of gastrointestinal anastomoses, to correct any defect under direct visualization, and to avoid early complications. However, this method seemed inadequate to predict late anastomotic complications.
Literature
1.
go back to reference Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic leaks after intestinal anastomosis. It’s later than you think. Ann Surg 2007;245:254–258.PubMedCrossRef Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic leaks after intestinal anastomosis. It’s later than you think. Ann Surg 2007;245:254–258.PubMedCrossRef
2.
go back to reference Ishihara S, Watanabe T, Nagawa H. Intraoperative colonoscopy for stapled anastomosis in colorectal surgery. Surg Today 2008;38:1063–1065.PubMedCrossRef Ishihara S, Watanabe T, Nagawa H. Intraoperative colonoscopy for stapled anastomosis in colorectal surgery. Surg Today 2008;38:1063–1065.PubMedCrossRef
3.
go back to reference Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ. Anastomotic leak testing after colorectal resection. What are the data? Arch Surg 2009;144:407–411.PubMedCrossRef Ricciardi R, Roberts PL, Marcello PW, Hall JF, Read TE, Schoetz DJ. Anastomotic leak testing after colorectal resection. What are the data? Arch Surg 2009;144:407–411.PubMedCrossRef
4.
go back to reference Kube R, Mroczkowski P, Granowski D, Benedix F, Sahm M, Schmidt U, Gastinger I, Lippert H. Anastomotic leakage after colon cancer surgery: a predictor of significant morbidity and hospital mortality, and diminished tumour-free survival. Eur J Surg Oncol 2010;36:120–124.PubMed Kube R, Mroczkowski P, Granowski D, Benedix F, Sahm M, Schmidt U, Gastinger I, Lippert H. Anastomotic leakage after colon cancer surgery: a predictor of significant morbidity and hospital mortality, and diminished tumour-free survival. Eur J Surg Oncol 2010;36:120–124.PubMed
5.
go back to reference Platell C, Hall J. Mechanical bowel preparation before colorectal surgery? Lancet 2007;370:2073–2075.PubMedCrossRef Platell C, Hall J. Mechanical bowel preparation before colorectal surgery? Lancet 2007;370:2073–2075.PubMedCrossRef
6.
go back to reference Lazorthes F, Chiotassol P. Stapled colorectal anastomoses: preoperative integrity of the anastomosis and risk of postoperative leakage. Int J Colorectal Dis 1986;1:96–98.PubMedCrossRef Lazorthes F, Chiotassol P. Stapled colorectal anastomoses: preoperative integrity of the anastomosis and risk of postoperative leakage. Int J Colorectal Dis 1986;1:96–98.PubMedCrossRef
7.
go back to reference Davies AH, Bartolo DC, Richards AE, Johnson CD, Mac Mortensen NJ. Intraoperative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 1988;70:345–347.PubMed Davies AH, Bartolo DC, Richards AE, Johnson CD, Mac Mortensen NJ. Intraoperative air testing: an audit on rectal anastomosis. Ann R Coll Surg Engl 1988;70:345–347.PubMed
8.
go back to reference Griffith CD, Hardcastle JD. Intraoperative testing of anastomotic integrity after stapled anterior resection for cancer. J R Coll Surg Edinb 1990;35:106–108.PubMed Griffith CD, Hardcastle JD. Intraoperative testing of anastomotic integrity after stapled anterior resection for cancer. J R Coll Surg Edinb 1990;35:106–108.PubMed
9.
go back to reference Gilbert JM, Trapnell JE. Intraoperative testing of the integrity of left-sided colorectal anastomoses: a technique of value to the surgeon in training. Ann R Coll Surg Engl 1988;70:158–160.PubMed Gilbert JM, Trapnell JE. Intraoperative testing of the integrity of left-sided colorectal anastomoses: a technique of value to the surgeon in training. Ann R Coll Surg Engl 1988;70:158–160.PubMed
10.
go back to reference Dixon AR, Holmes JT. Colorectal anastomotic integrity after anterior resection: is there a role for intraoperative testing? J R Coll Surg Edinb 1991;36:35–36.PubMed Dixon AR, Holmes JT. Colorectal anastomotic integrity after anterior resection: is there a role for intraoperative testing? J R Coll Surg Edinb 1991;36:35–36.PubMed
11.
go back to reference Wheeler JM, Gilbert JM. Controlled intraoperative water testing of left-sided colorectal anastomoses: are ileostomies avoidable? Ann R Coll Surg Engl 1999;81:105–108.PubMed Wheeler JM, Gilbert JM. Controlled intraoperative water testing of left-sided colorectal anastomoses: are ileostomies avoidable? Ann R Coll Surg Engl 1999;81:105–108.PubMed
12.
go back to reference Smith S, McGeehin W, Kozol RA, Giles D. The efficacy of intraoperative methylene blue enemas to assess the integrity of a colonic anastomosis. BMC Surg 2007;1:15–20.CrossRef Smith S, McGeehin W, Kozol RA, Giles D. The efficacy of intraoperative methylene blue enemas to assess the integrity of a colonic anastomosis. BMC Surg 2007;1:15–20.CrossRef
13.
go back to reference Li VK, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR. Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 2009;23:2459–2465.PubMedCrossRef Li VK, Wexner SD, Pulido N, Wang H, Jin HY, Weiss EG, Nogeuras JJ, Sands DR. Use of routine intraoperative endoscopy in elective laparoscopic colorectal surgery: can it further avoid anastomotic failure? Surg Endosc 2009;23:2459–2465.PubMedCrossRef
14.
go back to reference Beard JD, Nicholson ML, Sayers RD, Lloyd D, Everson NW. Intraoperative air testing of colorectal anastomoses: a prospective, randomized trial. Br J Surg 1990;77:1095–1097.PubMedCrossRef Beard JD, Nicholson ML, Sayers RD, Lloyd D, Everson NW. Intraoperative air testing of colorectal anastomoses: a prospective, randomized trial. Br J Surg 1990;77:1095–1097.PubMedCrossRef
15.
go back to reference Sakanoue Y, Nakao K, Shoji Y, Yanagi H, Kusunoki M, Utsunomiya J. Intraoperative colonoscopy. Surg Endosc 1993;7:84–87.PubMedCrossRef Sakanoue Y, Nakao K, Shoji Y, Yanagi H, Kusunoki M, Utsunomiya J. Intraoperative colonoscopy. Surg Endosc 1993;7:84–87.PubMedCrossRef
16.
go back to reference Carr ND. Intraoperative testing of the integrity of left-sided colorectal anastomoses: a technique of value to the surgeon in training [letter]. Ann R Coll Surg Engl 1988;70:397.PubMed Carr ND. Intraoperative testing of the integrity of left-sided colorectal anastomoses: a technique of value to the surgeon in training [letter]. Ann R Coll Surg Engl 1988;70:397.PubMed
17.
go back to reference Bruce J, Krukowski ZH, Al-Khairy G, Russel EM, Park KG. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 2001;88:1157–1168.PubMedCrossRef Bruce J, Krukowski ZH, Al-Khairy G, Russel EM, Park KG. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 2001;88:1157–1168.PubMedCrossRef
18.
go back to reference Frossard JL, Gervaz P, Huber O. Water-immersion sigmoidoscopy to treat acute GI bleeding in the perioperative period after surgical colorectal anastomosis. Gastrointest Endosc 2010;71:167–170.PubMedCrossRef Frossard JL, Gervaz P, Huber O. Water-immersion sigmoidoscopy to treat acute GI bleeding in the perioperative period after surgical colorectal anastomosis. Gastrointest Endosc 2010;71:167–170.PubMedCrossRef
19.
go back to reference Schmidt O, Merkel S, Hohenberger W. Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol 2003;29:239–243.PubMedCrossRef Schmidt O, Merkel S, Hohenberger W. Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol 2003;29:239–243.PubMedCrossRef
20.
go back to reference Longo WE. Anastomotic leak testing after colorectal resection. What are the data? [invited critique]. Arch Surg 2009;144:411–412.CrossRef Longo WE. Anastomotic leak testing after colorectal resection. What are the data? [invited critique]. Arch Surg 2009;144:411–412.CrossRef
21.
go back to reference den Dulk M, Marijnen CAM, Collette L, Putter H, Pahlman L, Folkesson J, Bosset JF, Rödel C, Bujko K, van de Velde CJ. Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery. Br J Surg 2009;96:1066–1075.CrossRef den Dulk M, Marijnen CAM, Collette L, Putter H, Pahlman L, Folkesson J, Bosset JF, Rödel C, Bujko K, van de Velde CJ. Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery. Br J Surg 2009;96:1066–1075.CrossRef
22.
go back to reference Tsikitis VL, Larson DW, Poola VP, Nelson H, Wolff BG, Pemberton JH, Cima RR. Postoperative morbidity with diversion after low anterior resection in the era of neoadjuvant therapy: a single institution experience. J Am Coll Surg 2009;209:114–118.PubMedCrossRef Tsikitis VL, Larson DW, Poola VP, Nelson H, Wolff BG, Pemberton JH, Cima RR. Postoperative morbidity with diversion after low anterior resection in the era of neoadjuvant therapy: a single institution experience. J Am Coll Surg 2009;209:114–118.PubMedCrossRef
23.
go back to reference Damrauer SM, Bordeianou L, Berger D. Contained anastomotic leaks after colorectal surgery. Are we too slow to act? Arch Surg 2009;144:333–338.PubMedCrossRef Damrauer SM, Bordeianou L, Berger D. Contained anastomotic leaks after colorectal surgery. Are we too slow to act? Arch Surg 2009;144:333–338.PubMedCrossRef
24.
go back to reference Linn TY, Moran BJ, Cecil TD. Staple line haemorrhage following laparoscopic left-sided colorectal resections may be more common when the inferior mesenteric artery is preserved. Tech Coloproctol 2008;12:289–293.PubMedCrossRef Linn TY, Moran BJ, Cecil TD. Staple line haemorrhage following laparoscopic left-sided colorectal resections may be more common when the inferior mesenteric artery is preserved. Tech Coloproctol 2008;12:289–293.PubMedCrossRef
25.
go back to reference Marra F, Steffen T, Kalak N, Warschkow R, Tarantino I, Lange J, Zünd M. Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer. Eur J Surg Oncol 2009;35:1060–1064.PubMed Marra F, Steffen T, Kalak N, Warschkow R, Tarantino I, Lange J, Zünd M. Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer. Eur J Surg Oncol 2009;35:1060–1064.PubMed
26.
go back to reference Kirchhoff P, Dincler S, Buchmann P. A multivariate analysis of potential risk factors for intra- and postoperative complications in 1,316 elective laparoscopic colorectal procedures. Ann Surg 2008;248:259–265.PubMedCrossRef Kirchhoff P, Dincler S, Buchmann P. A multivariate analysis of potential risk factors for intra- and postoperative complications in 1,316 elective laparoscopic colorectal procedures. Ann Surg 2008;248:259–265.PubMedCrossRef
27.
go back to reference Lustosa SA, Matos D, Atallah AN, Castro AA. Stapled versus handsewn methods for colorectal anastomosis surgery. Cochrane Database Syst Rev 2001;3:CD003144.PubMed Lustosa SA, Matos D, Atallah AN, Castro AA. Stapled versus handsewn methods for colorectal anastomosis surgery. Cochrane Database Syst Rev 2001;3:CD003144.PubMed
28.
go back to reference Nishikawa K, Yanaga K, Kashiwagi H, Hanyuu N, Iwabuchi S. Significance of intraoperative endoscopy in total gastrectomy for gastric cancer. Surg Endosc. doi:10.1007/s00464-010-1007-0. Nishikawa K, Yanaga K, Kashiwagi H, Hanyuu N, Iwabuchi S. Significance of intraoperative endoscopy in total gastrectomy for gastric cancer. Surg Endosc. doi:10.​1007/​s00464-010-1007-0.
29.
go back to reference Komen N, Dijk JW, Lalmahomed Z, Klop K, Hop W, Kleinrensink GJ, Jeekel H, Ruud Schouten W, Lange JF. After-hours colorectal surgery: a risk factor for anastomotic leakage. Int J Colorectal Dis 2009;24:789–795.PubMedCrossRef Komen N, Dijk JW, Lalmahomed Z, Klop K, Hop W, Kleinrensink GJ, Jeekel H, Ruud Schouten W, Lange JF. After-hours colorectal surgery: a risk factor for anastomotic leakage. Int J Colorectal Dis 2009;24:789–795.PubMedCrossRef
Metadata
Title
Endoscopic Intraoperative Anastomotic Testing May Avoid Early Gastrointestinal Anastomotic Complications. A Prospective Study
Authors
Eva Lieto
Michele Orditura
Paolo Castellano
Margherita Pinto
Anna Zamboli
Ferdinando De Vita
Carlo Pignatelli
Gennaro Galizia
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 1/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-010-1371-z

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