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International Journal of Colorectal Disease

Published in:

01-09-2010 | Original Article

Endocytoscopic classification of preneoplastic lesions in the colorectum

Authors: Gianluca Rotondano, Maria Antonia Bianco, Raffaele Salerno, Costantino Meucci, Antonio Prisco, Maria Lucia Garofano, Stefano Sansone, Livio Cipolletta

Published in: International Journal of Colorectal Disease | Issue 9/2010

Abstract

Purpose

The aim of this study is to assess the capability of endocytoscopy (ECS) in differentiating neoplastic from nonneoplastic lesions in the colorectum and to validate an ECS classification.

Methods

Patients with colorectal polypoid and nonpolypoid lesions ≤10 mm were prospectively included. ECS classification subgrouped nonneoplastic (EC 0) and neoplastic (EC 1–3) lesions. Lesions were observed at super-magnified view (450×) before endoscopic resection. Blinded pathological assessment was obtained.

Results

Fifty-two lesions were examined in 49 patients (17 polypoid and 35 nonpolypoid). Final pathological diagnosis was normal mucosa or hyperplastic polyp in ten cases, low-grade adenoma in 29, high-grade adenoma in 11, and submucosal invasive cancer in two cases. Positive predictive values of each EC group were 100%, 93.1%, 90.1%, and 100%, respectively. ECS diagnosis correlated completely with pathology in the differentiation between neoplastic and nonneoplastic lesions.

Conclusions

ECS enabled observation of colorectal lesion at a subcellular level in vivo. The classification of ECS images had a good correlation with the final pathological diagnosis. ECS was useful to differentiate between neoplastic and nonneoplastic lesions.

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Title: Endocytoscopic classification of preneoplastic lesions in the colorectum
Authors: Gianluca Rotondano
Maria Antonia Bianco
Raffaele Salerno
Costantino Meucci
Antonio Prisco
Maria Lucia Garofano
Stefano Sansone
Livio Cipolletta
Publication date: 01-09-2010
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 9/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-010-0969-7

At a glance: The STEP trials

Springer Medicine

Endocytoscopic classification of preneoplastic lesions in the colorectum

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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